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Biomedical subjects

F Colardyn

Publications and source records attributed to F Colardyn.

At least 91 records · Page 5Linked to original sources
PubMed1989

The availability of diltiazem: a study on the sorption by intravenous delivery systems and on the stability of the drug.

The stability and the sorption by intravenous delivery systems of the calcium antagonist diltiazem dissolved into either 5% dextrose or 0.9% sodium chloride solutions have been investigated, under conditions simulating current clinical practice. Static experiments showed an excellent stability and no sorption after 48 h. Dynamic experiments, at a perfusion rate of 20 mg h-1, showed no sorption of the drug by infusion fluid containers, burettes or administration sets. For end-line filters a temporary decrease of the recovered amount of diltiazem was observed but only with the 0.9% NaCl solution. It is concluded that the stability and the sorption of diltiazem offers no problem with regard to clinical efficacy.

Adsorption↗
PubMed1989

Endotoxin removal by end-line filters.

Four commonly used end-line filters, one with a charge-modified hydrophilic nylon filter (ELD96; Pall Biomedical Ltd., Portsmouth, United Kingdom), one with an unmodified nylon filter (FAE020; Pall Biomedical), and two with hydrophilic cellulose ester filters (Ivex-HP, Millipore Corp., Bedford, Mass.; Sterifix, Braun-Gelman, Brussels, Belgium), were evaluated for their endotoxin-removing capacity in saline and 5% glucose. Natural endotoxins derived from Escherichia coli 8739 and the lipopolysaccharide mutant Pseudomonas aeruginosa PA220-R2 and a purified E. coli serotype O111:B4 lipopolysaccharide preparation were used to challenge the four end-line filters. No endotoxin-removing capacity was observed for the Ivex-HP and Sterifix filters. Both the FAE020 and the ELD96 end-line filters showed excellent endotoxin-eliminating capacities in 5% glucose. Increasing the NaCl concentration in 5% glucose, however, greatly reduced the endotoxin-removing efficiency of especially the ELD96 filter for the purified E. coli lipopolysaccharide preparation. Obviously, both the nature of the endotoxin and the ionic strength of the solution had a major influence on the endotoxin end-line filtering efficiency.

Endotoxins↗
PubMed1988

Effect of propofol on elevated intracranial pressure. Preliminary results.

The effects of a bolus injection of propofol on mean intracranial pressure were studied in six adult, comatose patients who had severe head injuries. Propofol 2 mg/kg was given intravenously over 90 seconds when the mean intracranial pressure reached or exceeded 25 mmHg. Arterial blood gas values, heart rate and central venous pressure remained stable at all measurements. Arterial blood pressure decreased statistically significantly (p less than 0.05) within one minute after propofol administration. The mean (SEM) intracranial pressure decreased statistically significantly (p less than 0.05) at 30 seconds and at 1 and 2 minutes, from 25 (3) to 11 (4) mmHg. The cerebral perfusion pressure decreased statistically significantly from 92 (8) mmHg at all measurements (p less than 0.05). The lowest value at 3 minutes was 50 (7) mmHg but in four patients at that time the perfusion pressure was below 50 mmHg.

Adult↗
PubMed1988

Binding of drugs to end-line filters: a study of four commonly administered drugs in intensive care units.

The binding of diazepam, digoxin, dopamine and fentanyl to different 0.2 microns end-line filters was investigated under simulated infusion conditions. All the drugs were diluted in either 5% dextrose or 0.9% NaCl infusion fluid. For digoxin and diazepam a marked reduction in the amount of drug delivered to the patient in the first 20-60 min of infusion is observed. For dopamine, the drug loss was less pronounced and no fentanyl was absorbed to the filters during the infusion experiment.

Absorption↗
PubMed1988

The sorption of isosorbide dinitrate to intravenous delivery systems.

The sorption of isosorbide dinitrate from 0.9% sodium chloride and 10% glucose solutions, by intravenous delivery systems has been investigated under simulated infusion conditions. Isosorbide dinitrate was stable in both 0.9% sodium chloride and 10% glucose solutions. Intravenous fluid containers, burettes, a syringe, infusion sets and end-line filters were evaluated. Glass containers, methacrylate butadiene styrene burettes and polybutadiene giving sets did not sorb isosorbide dinitrate. Neither did polypropylene syringes when a 10% glucose solution was used. The sorption of isosorbide dinitrate to end-line filters was unimportant but there was a significant loss to the PVC tubing used to connect the filter housing to the catheter.

Adsorption↗
PubMed1987

Cardiac contusion.

During a consecutive period of 24 months, 244 patients with a major trauma were admitted to the Intensive Care Unit. From this pool of patients 60 consecutively were selected who did fulfill the selected criteria. We intended to determine within this studygroup the incidence, clinical features and outcome of patients with myocardial contusion (MC). We could conclude that no currently used diagnostic test may be seen as an accurate prediction of patients who still develop morbidity or mortality from cardiac contusion. Data from the literature suggest that at present only radionuclide angiography, direct hemodynamic measurement with construction of a Starling curve, and/or 2D-echocardiography may be useful in the identification of the patients at the greatest risk and predictive of the severity of the myocardial injury.

Adult↗
PubMed1987

Renal function in burns.

The present study evaluates the evolution of renal function parameters and serum electrolytes in 34 severely burned patients. The population was arbitrarily subdivided in a group with normal renal function (n = 24) and a group with acute renal failure (n = 10), defined by the fact that serum creatinine rose above 2.5 mg/dl at least once. The patient group with normal renal function was characterized by a normal to high creatinine clearance, reaching a consistent peak at day 2 of follow-up. Serum sodium and fractional sodium excretion were low. Further disturbances were a low serum protein, an early hypocalcemia and hypophosphatemia, and a discrete metabolic alkalosis. The patients developing acute renal failure maintained a low fractional sodium excretion. They were in general of older age and had more severe burns than the patients with normal renal function. The survival rate in the patients with acute renal failure was 30%, compared to 75% in the patients, who maintained normal renal function.

Acute Kidney Injury↗
PubMed1986

Ventricular pacing via a Swan Ganz catheter: a new mode of pacemaker therapy.

Hemodynamic monitoring via a Swan Ganz catheter is often required with critically-ill patients. In the further course of the illness emergency temporary pacing might be necessary, most frequently for AV-conduction disturbances or sinus bradycardia. Insertion via the right internal jugular vein has been used in many cases. This raises the problem that one may find a second central vein, which can lead to serious problems and in any case may be a dangerous waste of time. Recently we had the opportunity to stimulate the right ventricle with a small pacing wire, brought into the ventricle via a Swan Ganz catheter especially designed for this purpose with an extra lumen ending in the right ventricle of the heart. In this account we describe our experience with the first ten patients to whom this method was applied.

Adult↗
PubMed1985

Surgical repair of acute postinfarction cardiac rupture.

Acute myocardial infarction is complicated by cardiac rupture in 4% to 24% of all infarction deaths, and approximately 10% of hospital infarction deaths. There are no reliable indices to determine which patients run an increased risk of cardiac rupture. This report describes the surgical treatment and outcome of a patient who sustained a rupture of the left ventricular free wall, nine days after extensive anterior myocardial infarction.

Electrocardiography↗
PubMed1984

Paraquat poisoning.

A fatal case of paraquat poisoning is described. Postmortem concentration of paraquat in different tissues reveals that treatment in this case could not prevent lethal tissue accumulation. Although accumulation was more pronounced in renal tissue, lung toxicity caused death. The formation of enormous fecaliths and the appearance of hypercalcemia are reported. Both were most likely connected with Füllers earth therapy. In spite of the fact that the exact nature of the equilibrium between plasma levels and tissue accumulation of paraquat (static or dynamic) is not understood, aggressive treatment must be recommended, even after the distribution phase and despite likely "fatal" plasma levels.

Adult↗