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Biomedical subjects

F Collins

Publications and source records attributed to F Collins.

At least 127 records · Page 7Linked to original sources
PubMed1977

The effect of hyperimmunization with Neisseria gonorrhoeae on the presence of gonococcal antibody in serum, tissues, and secretions of the rabbit.

Antibody responses in sera, tissues, and secretions of the urogenital tract and lower respiratory tract of rabbits hyperimmunized with Neisseria gonorrhoeae were examined. Antibody was detected by passive hemagglutination, whole-cell agglutination, bentonite flocculation, and in some cases immunodiffusion-in-gel. Immunization of rabbits either intravenously or intramuscularly resulted in the presence of gonococcal antibodies in the sera, spleens, and tissue of the urogenital tract (vagina, cervix, uterus, and fallopian tubes). Gonococcal antibody was also found in secretions bathing the mucosa of the urogenital tract and lower respiratory tract. Antibodies were not detected in sera, tissues, and secretions of non-immunized rabbits. The spleen was shown to synthesize gonococcal antibody in vitro in response to hyperimmunization. Tissues of the urogenital tract did not appear to synthesize gonococcal antibody thus suggesting and antibodies present in secretions of the urogenital tract were derived mainly from serum.

Agglutination Tests↗
PubMed1977

Inhibition of attachment of Neisseria gonorrhoeae to tissue cells by goat milk antigonococcal immunoglobulin G.

An immunoglobulin G (IgG)-containing fraction was isolated from milk, obtained from a goat before and after instillation of the mammary gland with Neisseria gonorrhoeae colony type 1 (T1). The presence of IgG and the absence of immunoglobulins-A and -M in this fraction was confirmed by immunodiffusion in gel and immunoelectrophoresis. Postinstillation IgG inhibited the attachment of the homologous strain of N. gonorrhoeae (T1) to tissue cells. The percentage of Rhesus monkey kidney cells with gonococci attached was 38.9% +/- 6.4. Inhibition was significant (P less than 0.01) when compared to the inhibitory effect of preinstillation IgG (73.5% +/- 3.1) or buffer control )76.8% +/- 2.8). Absorption of postinstillation IgG with rabbit anti-goat IgG or whole cell gonococci removed the inhibitory effect. Postinstillation IgG gave little or no inhibition of attachment (maximun 13%) of seven heterologous (T1) strains of N. gonorrhoeae to tissue cells. These results may provide a reason for recurrent gonococcal infection in humans despite the presence of circulating antibody (IgG) to N. gonorrhoeae. Such an antibody, if present in secretions bathing the mucosa, may fail to prevent infection and colonization of the urogenital tract by a different immunotype of N. Gonorrhoeae.

Animals↗
PubMed1975

Physiologic correlates of affect during psychotherapy.

Eight physiologic parameters were correlated with global ratings of affect intensity in four psychotherapeutic interviews with one patient. Highly significant covariation of affect with five of the eight physiologic parameters was obtained. It was concluded that affect intensity may be a useful psychologic parameter in studying psychophysiologic relationships in psychotherapy.

Adult↗
PubMed1975

Intellectual and attitudinal characteristics of medical students selecting family practice.

Family practice residents were compared with residents in internal medicine, surgery, obstetrics-gynecology, and pediatrics in terms of cognitive and non-cognitive characteristics. Family practice residents were in most instances significantly different from the other four groups. On non-cognitive measures they scored higher on affiliation need and lower on aggression and materialism. Their scores on several cognitive measures were among the highest of the five groups. These results were contrary to others from earlier studies. However, if the trend reported here is confirmed on other samples, it is the more intellectually gifted and idealistic physician who is currently being attracted to the practice of family medicine.

Attitude of Health Personnel↗
PubMedDate not supplied

CNTF rescues motoneurons from ontogenetic cell death in-vivo, but not in-vitro.

We studied the effect of CNTF (ciliary neurotrophic factor, human recombinant and chick) on the survival of motoneurons in the embryonic chick lumbar spinal cord during the period of ontogenetic cell death. Daily applications of 5 micrograms CNTF to the chorionic-allantoic membrane from embryonic day 6 (E6) to E9 maintained approximately 15,500 motoneurons as opposed to 13,200 in controls. In contrast, CNTF failed to promote the survival of cells in spinal cord cultures enriched for motoneurons. These results suggest that CNTF may regulate motoneuron survival in-vivo, but its mode of action remains to be elucidated.

Animals↗
PubMedDate not supplied

Use of Pressurease and Airform mattresses in pressure ulcer care.

Large cell dynamic air mattresses are effective in the prevention of pressure ulcers but they still have inherent problems, e.g. the ability of the mattresses to move patients along the mattress through the inflation and deflation of the cells. Also, there have been reports that the inflation and deflation of cells can cause motion sickness. This article reviews two mattresses from Sareo Healthcare Ltd: a static system, Pressurease; and a unique dynamic system, Airform. These two systems offer a cost-effective and clinically effective method of pressure ulcer prevention and therapy.

Aged↗