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Biomedical subjects

F Doyon

Publications and source records attributed to F Doyon.

At least 37 records · Page 2Linked to original sources
PubMed1991

Trends in cancer mortality, France 1950-1985.

Trends in mortality for main cancer sites in France between 1950 and 1985 are presented by sex. In the population aged 35-65, where long term trends can most reliably be assessed, an overall 1.1% mean annual increase is observed for males and a 0.6% mean annual decrease is observed for females. For males, this increase in total cancer mortality is mostly due to the sites associated with tobacco and alcohol. The important increase for lung cancer, and lesser increases for bladder, pancreas and kidney cancers are related to the increase in tobacco consumption from 4.7 g per adult per day in 1950 to 6.3 g in 1976. For cancer sites associated with alcohol and tobacco, namely oesophagus, pharynx, larynx, tongue and mouth, mortality is increasing similarly for males and for females, although these cancers are much less frequent among females. For females, the overall moderate decrease is mostly due to the decrease in cervix and stomach cancer mortality, uncompensated by the observed increase in breast cancer; there is no marked increase in lung cancer mortality for women, contrary to what is observed in other Western countries.

Adult↗
PubMed1990

Review of randomized trials of homoeopathy.

The present review covers forty published randomized trials in which the results of a homoeopathic treatment were compared to those of a standard treatment, a placebo, or no treatment at all. These trials were identified after an extensive search through the literature. They cover a wide range of pathologies. Most were double-blind and used subjective and/or multiple endpoints. The median number of patients per group was 28. The analysis only included all the randomized patients in one third of the trials. In our opinion, the results do not provide acceptable evidence that homoeopathic treatments are effective.

Double-Blind Method↗
PubMed1989

[Evaluation of therapeutic trials published apropos of antibiotic prophylaxis in orthopedic surgery].

The authors review all the randomized clinical trials published since 1970 which evaluate the efficacy of antibiotic prophylaxis in orthopaedic surgery. Evaluation of the quality of these trials was based on two clinical and four methodological criteria. They also take into account reports which aim to define the best antibiotic prophylactic protocol, particularly with regard to the duration of treatment. In conclusion, although the majority of trials do not escape criticism, the efficacy of antibiotic prophylaxis in orthopaedic surgery can be considered as demonstrated. The duration of treatment is still an open problem. At the present time, the duration of drainage defines the length of antibiotherapy.

Anti-Bacterial Agents↗
PubMed1988

Two-day cefamandole versus five-day cephazolin prophylaxis in 965 total hip replacements. Report of a multicentre double blind randomised trial.

The aim of this trial was to compare a 5-day course of cephazolin with a regimen of 2 days of cefamandole in 965 total hip replacements (488 in the cefamandole group and 477 in the cephazolin group). The effect of the prophylactic antibiotic on the bacterial colonization of drains (mean duration of drainage: 3.2 +/- 0.3 days) and on the susceptibility of colonizing organisms was assessed. No significant difference was observed in the percentage of infected drains between the two groups. The cefamandole group had a lower rate of Gram-negative organisms (23% versus 44%, p less than 0.01). The rate of deep infections within one year after operation was 0.7% in the cefamandole group versus 0.5% in the cephazolin group, and the difference is not significant. Cefamandole given for two days appears to be an effective prophylaxis against sepsis in total hip replacements.

Aged↗
PubMed1986

[Methodological framework of the evaluation of systematic screening and treatment of preexistent lesions of the colon and the rectum].

Among the conditions which need to be filled when generalizing the mass screening of polyps in view of the secondary prevention of colorectal cancers, three are already present: 1) it is a frequent and serious cancer; 2) there is an affiliation between benign tumours and cancer; 3) an effective non-mutilating treatment of benign tumours is available. On the other hand, two additional conditions remain unfilled and yet lie within the domain of research by methodologically rigorous studies: the setting up of a screening test with a high cost-effectiveness relationship; the epidemiological demonstration of the decreasing incidence of colorectal cancers following screening and treatment of precancerous lesions.

Adult↗
PubMed1984

[Secondary prevention of cerebral infarction caused by atherosclerosis. 3-year comparison of flurbiprofen and an ergot derivative].

A multicentre controlled trial was conducted on 383 patients to compare the effectiveness of flurbiprofen (100 mg/day) and an ergot derivative in preventing cerebral infarction. The end-point of the trial was recurrence within 3 years of treatment with one or the other drug of a fatal or non-fatal cerebral infarction. Only those patients who had already experienced an established and disabling ischaemic accident in the carotid or vertebro-basilar territory were included; 88% of these entered the trial less than 6 weeks after the accident. Sixty-one patients had recurrent cerebral infarction during the 3-year observation period: 22 in the flurbiprofen group and 39 in the ergot derivative group (p less than 0.02 log rank test adjusted by centre). The actuarial recurrence rates in the two groups were 13% and 21% respectively. These results concur with those of other trials involving aspirin to demonstrate the value of antiplatelet aggregation drugs in the secondary prevention of atherothrombotic cerebral infarction.

Arteriosclerosis↗
PubMed1982

[Relation between mortality in cancer of the pancreas and food and tobacco consumption in France].

The relationship is given between French pancreatic cancer mortality rates form 1968 to 1976, and some nutritional variables and tobacco. Positive correlations were found between the death rate from pancreatic cancer and sugar, egg and cereal consumption; however, a negative correlation was found with tobacco consumption. A stepwise multiple regression procedure showed an association between the mortality rate from cancer of the pancreas and meat and oil consumption when age had been taken into account.

Adult↗
PubMed1981

[Systematic hip roentgenograms in infants of 4 months of age in the screening for congenital dislocation of the hip (author's transl)].

The authors report the results of a statistical study undertaken for the screening of congenital dislocation of the hip. 961 children born between September 24, 1977 and June 30, 1978 were examined. Congenital dislocation of the hip was diagnosed in 9 (0.9 % of the cases). Out of these, 4 had no clinical sign of dislocatability at birth. The only determination of acetabular angles cannot be relied upon and qualitative criteria such as ilium thickness must be added.

Female↗
PubMed1978

[Survey on the fate of newborn infants treated in pediatric intensive care units. II. Respiratory sequelae].

Five hundred sixty children treated at the neonatal period (between 1969 and 1972) were reexamined when they were 1 and/or 2 years old. At 2 years of age, the rate of anomalies considered as probable respiratory sequellae of the neonatal disease, was 10%. In this population, hyaline membrane disease was responsible for nearly 2/3 of the respiratory sequellae observed at 2 years of age, whereas it concerned less than 1/3 of the population under study. The overall prognosis of neonatal disorders for which treatment in an intensive care unit was required during the 4 years under consideration, is clearly improving, since the decrease of death-rate is not associated with an increase of respiratory sequellae among the survivors.

Follow-Up Studies↗
PubMed1978

[Inquiry on the future of newborns treated in intensive care units for children. III. Neurologic anomalies].

This study concerned newborns admitted between 0 and 10 days of life at the intensive care unit of the Hospital St-Vincent-de-Paul from 1969 to 1972. They were followed later as outpatients. Out of 1,607 newborns admitted, 1,126 survived (average mortality: 30%). 532 were examined after one year, 397 after two years. On the whole prognosis may be considered as good: at 2 years of age, 8% had major neurologic abnormalities; 4% minor abnormalities, no increase in the percentage of major neurologic abnormalities between 1969 (6%) and 1972 (5%), whereas mortality decreased from 36 to 24%. The various types of neurologic deficits were analyzed, according to their effects on rehabilitation (4% had severe retardation, 11% moderate retardation). The sensory involvement (3%) and intercurrent seizures (10%) were also analyzed. According to the bias of the Unit in recruitment, this enquiry concerned children close from term or medium premature children (B.W. 1,500 g) : this diminishes the true rate of the neurologic deficit. The relationships between etiology of neonatal distress and delayed neurologic abnormalities are emphasized.

Central Nervous System Diseases↗
PubMed1977

Natural history of ventricular septal defect. A study involving 790 cases.

The development of 790 untreated patients affected by ventricular septal defect (VSD) has been the object of a 25-year study. Of these patients, 72% had had at least one catheterization; 13% had several. The mean observation interval is six years, and the average age at the latest data is 19.5 years. This study covers 4717 patient-years. For the entire population, the incidence rate or aortic regurgitation is 6.3% (4.3 for 1000 patient-years) and that of bacterial endocarditis is 3.7% (2.4 for 1000 patient-years). Twenty-five patients died, 15 of them between the ages of one and 39. Of the 499 cases with several clinical examinations, 71% remained stable. In 21%, changes suggesting some level of closure developed; in 7%, infundibular stenosis began to evolve and in 1% pulmonary vascular disease began to appear or became accentuated. These different rates are studied and discussed in relation to patients' age, VSD type, and various follow-up characteristics.

Adolescent↗
PubMed1977

[Prognosis for infants treated in pediatric intensive care units].

The first part of the inquiry reported herein is dealing with the diagnostic distribution and the death-rate of a population of 1,607 newborns, admitted for vital distress and treated in an intensive care unit for children from 1969 to 1972. Global death-rate reached 30%. 49% of the patients were admitted for different neonatal respiratory diseases: they were responsible for 31% of the deaths. Perinatal cerebral suffering was the principal cause for admission for 15% of the newborns: with a 40% death-rate, it was responsible for 20% of deaths. However, from 1969 to 1972, global death-rate was constantly decreasing, from 36 to 24%. This improvement concerns especially the respiratory diseases and the perinatal cerebral suffering.

Humans↗