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Biomedical subjects

F Doyon

Publications and source records attributed to F Doyon.

43 records · Page 3Linked to original sources

[Statistical study of the relationships between the etiology and clinical picture of cerebral palsy].

846 children with cerebral palsy were examined and 642 were selected for a statistical study by correspondence analysis. The aim was to identify without any prior assumptions, the relationships between the aetiological factors and the clinical findings. The study was completed by conventional statistical analysis of 584 of the cases. Small birth weight and a history of abnormal pregnancies was associated with a cerebral palsy affecting both legs, and often with a squint. Resuscitation was associated with athetosis and abnormalities of posture and behaviour. If the resuscitation lasted for more than 15 minutes or there were certain problems during delivery, severe abnormalities of both arms and major speech difficulties were observed. Resuscitation for less than 15 minutes or for an unknown time or intractable vomiting during pregnancy was associated with quadraplegia. Hemiplegia was related to post natal events but the aetiology was not always known. Foeto-maternal incompatibility was associated with athetosis, deafness, severe speech problems and ophthalmoplegias.

Abortion, Threatened↗

[Mortality from cancer in France. Changes between 1950 and 1989 in the population aged 35-64].

In the French population aged 35-64, cancer mortality increased yearly by 1 percent in males and decreased yearly by 0.6 percent in females between 1950 and 1989. In males, the increase is mostly due to the sites associated with tobacco and alcohol. The important increase of lung cancer is related to the increase in tobacco consumption from 4.7 g per adult per day in 1950 to 6.3 g in 1976. The increase observed in head and neck cancers is related to tobacco and alcohol. In females, the moderate decrease is due to the decrease observed in uterine cervix and stomach cancer mortality, uncompensated by the increase in breast cancer. Contrary to what is observed in the USA, there is no marked increase in lung cancer mortality for women.

Adult↗

[Analysis of results of a trial using the subject as its own control with a criterion of binary response].

The two-period cross-over design is often used in clinical trials in which subjects serve as their own controls. This procedure may produce a more powerful test, but also may produce bias due to carry-over effects. Three tests have been proposed for the analysis of two-period binary response cross-over trials (McNemar, Gart and Prescott). These tests and a simple test for the carry-over effect are presented in this paper. The contrasts used are similar for the three tests, but McNemar's test does not allow an order effect, contrary to the other methods. The Prescott's test is more powerful, but calculations are heavy and need computer assistance. Therefore, McNemar's test can be used as a first approximation.

Clinical Trials as Topic↗