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Biomedical subjects

F Eberli

Publications and source records attributed to F Eberli.

5 recordsLinked to original sources
PubMed1998

Enhanced coronary vasoconstriction after PTCA in patients with acute ischemia.

UNLABELLED: Coronary vasoconstriction of the distal vessel segment has been reported after percutaneous transluminal coronary angiography (PTCA), which was explained by increased vasoconstrictor influences. In patients with acute ischemia these changes may be even enhanced. Thus, vasomotion of the epicardial coronary arteries was studied before and after PTCA in patients with acute ischemia due to unstable angina or acute infarction. METHODS: 52 patients were divided into 2 groups: Group 1 (controls) consisted of 31 patients who underwent elective (PTCA) and group 2 of 21 patients who underwent emergency PTCA for unstable angina or acute infarction. Coronary artery dimensions proximal and distal to the culprit lesion were determined by quantitative coronary angiography before and after PTCA as well as after 0.2 mg nitroglycerin i.c. at the end of the procedure. RESULTS: Stenosis severity was similar before and after PTCA in both groups (before, 91 +/- 8% in group 1 vs 90 +/- 9% in group 2; after, 28 +/- 9% vs 23 +/- 10%, resp.). Heart rate and mean blood pressure remained unchanged. In the group with acute ischemia no vasodilation of the proximal (2 +/- 3%) and distal vessel (-1 +/- 4%) occurred after PTCA, whereas in the control group significant vasodilation of both vessel segments (11 +/- 2% resp. 13 +/- 3%) was found. The response to nitroglycerin was maintained in both groups. In the control group there was a significant correlation between stenosis severity and percent diameter change of the distal vessel segment. However, in the acute ischemic group this relationship was shifted downwards suggesting an enhanced vasoconstrictor response in these patients. CONCLUSIONS: Epicardial coronary arteries in patients with acute ischemia show an enhanced vasoconstriction after PTCA. Nevertheless, the response to nitroglycerin is maintained suggesting that functional (endothelial dysfunction) rather than structural factors are responsible for this phenomenon.

Adult↗
PubMed1994

[Bromocriptine-induced pleuropneumopathy].

A 64-year-old man was diagnosed to have Parkinson's disease when aged 42 years and since then has been treated with levodopa and benserazide (up to 875 mg daily). Bromocriptine (up to 35 mg daily) was added to the medication 9 years ago. 3 1/2 years ago he developed exertional dyspnoea (NYHA class II-III) and lost 5 kg in weight. Chest radiography demonstrated pleural effusion and interstitial pulmonary changes in both lung bases. Erythrocyte sedimentation rate was 37 mm in the first hour and the white cell count 10,400/microliters. Extensive tests failed to find malignant tumour or any infectious-inflammatory condition. As it was suspected that the pleuropulmonary changes were associated with the bromocriptine intake, it was discontinued and biperiden and selegiline substituted for it. The pleural effusion regressed almost completely within 8 weeks, and the laboratory tests pointing to inflammation disappeared completely. Clinical, biochemical and radiological tests have remained normal for the last 3 years. The clinical course makes a causal relationship between bromocriptine intake and the pleuropulmonary changes highly probable.

Benserazide↗
PubMed1990

[Quantitative Doppler echocardiography in the evaluation of heart diseases].

Doppler ultrasound is an established noninvasive method in cardiology. The most important indications are: 1. stenosis/insufficiencies of atrioventricular/semilunar valves, 2. dysfunction of artificial valves, 3. atrial and ventricular septal defects, 4. intraventricular pressure gradients, e.g. in hypertensive cardiomyopathy, 5. determination of the systolic pulmonary artery pressure. Color Doppler and pulsed wave Doppler as mainly used for quantitative and semiquantitative-, continuous wave Doppler mainly for quantitative analyses. Doppler it can be obtained qualitative and semiquantitative, from continuous wave Doppler quantitative information about the velocity of blood flow.

Cardiomyopathies↗
PubMed1989

Quantification of mitral regurgitation with amplitude-weighted mean velocity from continuous wave Doppler spectra.

Amplitude-weighted mean velocity from continuous wave (CW) Doppler spectra was used to measure aortic flow (QAo) and left ventricular mitral inflow (QLVin). These flows were used to quantify mitral regurgitation fraction: RFm = (QLVin-QAo).QLVin-1.100(%).QLVin was calculated from the diastolic time integral of amplitude-weighted mean velocity that was derived from CW spectra with the transducer placed in the apical window and the CW beam directed toward the left ventricular inflow tract. QAo was obtained from the systolic time integral of amplitude-weighted mean velocity by using the same apical window and directing the CW beam toward the left ventricular outflow tract. In 20 normal subjects, RFm ranged between -6.2% and +8% (mean, -0.8%). In 25 patients with pure mitral regurgitation, RFm obtained by Doppler (y) was compared with RFm calculated from biplane left ventriculography and the Fick method (x). The correlation was r = 0.96, SEE = 6.1% of the mean or 12% of the angio-Fick mean; the regression line was y = 0.96x + 0.18; mean y = 49%, mean x = 51%. It is concluded that RFm can be determined accurately by using amplitude-weight mean velocities from CW Doppler spectra. The advantages of this method are its independence from the measurement of the left ventricular inflow or outflow tract area.

Adult↗