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F Eusebi

Publications and source records attributed to F Eusebi.

117 records · Page 7Linked to original sources
PubMed1976

Stoichiometry of hemolysis by the polyene antibiotic lucensomycin.

The stoichiometry of hemolysis by the polyene antibiotic lucensomycin was investigated. It appears that hemolysis occurs only when a relatively high fraction (probably between 15 and 40%) of the cholesterol sites in the erythrocyte membrane have combined with the polyene. Also in phospholipid-cholesterol vesicles the increase of permeability requires occupancy of 40-50% of the existing cholesterol sites. As for the possible cooperative effect in the hemolytic process, it is probable that several (at least 9-10) lucensomycin-cholesterol adducts must interact on each side of the membrane to form an aqueous channel; the distribution of these adducts in the erythrocyte membrane occurs, however, apparently at random.

Animals↗
PubMedDate not supplied

Acetylcholine sensitivity in replicating satellite cells.

Mononucleate myogenic cells lying within skeletal muscle fiber endomysium, the so-called satellite cells (SC), isolated from adult leg muscle of normal or dystrophic mice were studied by electrophysiological techniques. Normal SC responded to iontophoretic acetylcholine (ACh) by depolarization even during the replicative phase. Acetylcholine sensitivity increased after cell fusion. Replicating SC from dystrophic muscle did not exhibit any sensitivity to ACh, and neither did embryonic myoblasts.

Acetylcholine↗