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Biomedical subjects

F Fakan

Publications and source records attributed to F Fakan.

At least 55 records · Page 3Linked to original sources
PubMed1992

Papillary carcinoma of thyroid with exuberant nodular fasciitis-like stroma.

We describe two cases of papillary carcinoma of the thyroid containing prominent nodular, fasciitis-like stroma. In one of the cases infiltration into the adjacent parathyroid gland and metastases to two cervical lymph nodes occurred. In the lymph nodes and the parathyroid gland the carcinoma grew without any fasciitis-like stroma. This unusual change in tumour stroma seems to be reactive in nature and confined only to the thyroid and adjacent soft tissues.

Adult↗
PubMed1992

Myoid differentiation in vascular transformation of lymph node sinuses due to venous obstruction. Immunohistochemical and ultrastructural studies.

Five cases of vascular transformation of lymph node sinuses due to venous obstruction are described in this paper. Evidence was found in four cases to actin immunoreactivity, and involvement of myofibroblasts was electronmicroscopically observed in one case. Differential diagnosis of vascular transformation of lymph node sinuses is discussed. The lesion is similar to KAPOSI's sarcoma-like subcutaneous processes and to chemodectoma-like bodies in the lung.

Adult↗
PubMed1990

[Myelodysplastic syndromes].

Myelodysplastic syndromes (MDS) are a group of heterogenous disorders of blood and of the haematopoeitic bone marrow which have been recently in the center of interest of both clinical haematologists and pathologists. The FAB classification is based on cytology; for histological assessment, a special histopathological classification appears to be more appropriate. The main histological findings in MDS and some ultrastructural changes are shown in 138 bone marrow biopsies from 81 patients with MDS. Histological examination brings some findings that cannot be obtained by cytology. Optimal samples well processed can give valuable information without need of special staining methods. The latter can complement the basic information with some additional data or compensate for some technical defects of the slides.

Bone Marrow↗
PubMed1990

[Thrombotic thrombocytopenic purpura. Report of 2 cases].

The authors present a report on thrombotic thrombocytopenic purpura in a 63-year-old woman and a 23-year-old man. In both the disease was diagnosed in vivo. In the first case the patient died in the fulminant stage, in the second case, treated for three weeks, death occurred after an infectious complication. In the first case necropsy confirmed the florid stage of the disease, in the second case only late non-specific changes were detected. The varied and prolonged history of the second case can be explained by repeated attacks of the disease, the last one being fatal.

Adult↗
PubMed1987

Demonstration of needle-shaped hepatic inclusions in porphyria cutanea tarda using the ferric ferricyanide reduction test.

In 18 of 19 biopsy and 2 of 3 autopsy samples of hepatic tissue from cases of porphyria cutanea tarda needle-shaped cytoplasmic inclusions are capable of reducing ferric ions in the ferric ferricyanide reduction test. Thanks to the resulting Turnbull's Blue the inclusions are clearly visible, which facilitates their histological demonstration. In 20 biopsy and 20 autopsy samples of hepatic tissue from cases other than porphyria cutanea tarda the inclusions are not present. These needle-shaped inclusions are thus considered to be a specific histological feature. The ferric ferricyanide reduction test represents a simple method for their visualization, which can be used in routine diagnostic practice.

Ferricyanides↗
PubMed1986

Pleiomorphous histiocytic sarcoma arising in a patient with histiocytosis X.

An adult woman was followed up for the occurrence of multiple successive cutaneous and mucosal tumors of small size and classical histiocytosis X structure (histiocytoeosinophilic granuloma). In the second phase of the patient's clinical history there were successively appearing nodular or infiltrative cutaneous and subcutaneous tumors histologically resembling polymorphocellular sarcoma close either to malignant lymphogranuloma or to recently described "regressing atypical histiocytosis". Despite the marked cellular atypia and polymorphism the tumors exhibited a relatively favorable clinical course. Beside clearly sarcomatous structures, some of them displayed also transitional structures to histiocytosis X. Immunohistologically the atypical cells showed features of both the Langerhans' line and non-specific histiocytes. Ia-like antigen was positive in most of the elements. Quite occasional cells contained detectable amount of S-100 protein. Electronmicroscopy revealed quite sporadic structures resembling Langerhans granules.

Female↗
PubMed1985

[A fatal disease of the heart in primary and secondary hemochromatosis].

In a 53 year-old man suffering from idiopathic hemochromatosis a massive myocardial siderosis occurred with disperse necroses and fibroses especially in subepicardial zone of the left ventricle. A similar picture was observed at secondary hemochromatosis in a 33 year-old woman with sideroblastic anemia after repeated blood transfusions. Both patients died of the failure of hypertrophic heart.

Adult↗
PubMed1981

Histochemical and biochemical observations of the spleen in atypical Niemann-Pick disease and in idiopathic thrombocytopenic purpura.

In a case of adolescent Niemann-Pick disease (NP) and in a case of idiopathic thrombocytopenic purpura (ITP), the histologic picture of the spleen showed appreciable similarity in localization of sparing cells and in a number of histochemical tests. The sphingomyelin, which was the main organ phospholipid in both conditions, contained substantially elevated content of C24 fatty acids. Detailed analysis of spleen lipids showed great relative increase of lysobisphosphatidic acid and of cholesterol which was in NP mainly in free form but in ITP surprisingly mainly esterified, mostly to oleic and palmitic acid. Possible molecular mechanism of sphingomyelin storage was enzymologically followed in model conditions using separated lipid fractions from NP's spleen. The activity of sphingomyelinase (Cl. perfringens exotoxin) was in comparison to phospholipase C relatively specifically inhibited by lysobisphosphatidic acid.

Adult↗
PubMed1981

Diagnostic value of PB/KOH/PAS method for identification of primary cancer from metastases.

The demonstration of 0-acylated sialic acids in the mucin of cancer metastases by Culling's periodic acid-borohydride-potassium hydroxide-periodic acid-Schiff method (PB/KOH/PAS) is helpful in distinguishing between mucin-producing primary colorectal adenocarcinoma (which will be in 60 to 70% positive) and mucin-producing primary lung adenocarcinoma (which will be negative). In addition to colorectal mucin, the 0-acylated sialic acids may be demonstrated in the mucin of some gastric and gallbladder carcinomas, and only exceptionally in pancreatic, ovarian, and prostatic cancers.

Adenocarcinoma↗
PubMed1980

[Inflammatory fibrous histiocytoma].

A busky tumour of yellow colour with pus-filled central cavities was removed from the left retroperitoneum of a 54 year old man. Histology revealed it to be a rare variant of fibrous histiocytoma characterized by an extremely large quantity of mature neutrophil granulocytes in all the tumour tissue messively phagocyted by tumour histiocytes. There was no relapse or dissemination when postmortem was performed 5 months after the operation.

Histiocytoma, Benign Fibrous↗
PubMed1979

[Myelosarcoma as the 1st manifestation of myelosis].

Myelosarcoma of the nodes, middle ear, rib, and spinal epidural space was observed in five cases as preceding the diagnosis of myelosis. In two cases involving epidural localization malignant lymphoma was misdiagnosed and reclassification only at the time of postmortem. Myelosarcoma is best distinguished from other types of tumour by means of the histochemical proof of naphthol-AS-D-chloracetatesterase.

Adult↗