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Biomedical subjects

F Fetissof

Publications and source records attributed to F Fetissof.

86 records · Page 5Linked to original sources
PubMed1984

[Cancer of the larynx and computed x-ray tomography: exploration of the hypothyroepiglottic area and paraglottic space].

Twenty patients with laryngeal cancer were explored by tomography and a CT scan. Results were compared between cases and, for operated patients, with histosurgical findings. Results of this study and a review of the literature suggest that the CT scan is the most adapted examination for exploration of the paraglottic and hypothyroepiglottic spaces, but that caution should be exercised when assessing results.

Epiglottis↗
PubMed1983

Immunocytological study of the distribution of C-cells calcitonin in the thyroid gland of the normal adult gerbil.

The distribution of C-cells in the thyroid gland of the gerbil (Meriones inguiculatus) was studied on serial sections in the cranio-caudal direction. C-cells were visualized by immunofluorescence with an anti-calcitonin immune serum. A very heterogeneous distribution was found. C-cells first appear in the posterio-interior position. Then they progressively occupy the whole posterior part and finally are confined to the posterio-exterior position. No C-cells at all were detected in the upper and lower poles. According to the species, there is a wide variation in the relative distribution of C-cells in the thyroid gland. Our results add to the information available about the distribution of C-cells and its bearing on phylogenic evolution.

Animals↗
PubMed1983

Endocrine cells in the prostate gland, urothelium and Brenner tumors. Immunohistological and ultrastructural studies.

Endocrine cells are a normal constituent of the prostate gland, prostatic urethra and urinary bladder mucosa. Positive results using immunohistochemical technics were obtained only with antiserotonin antibodies. In normal tissues, there was a close similarity between the distribution of argyrophilic cells (Grimelius) and serotonin-storing cells. Some striking features were the patchy distribution of endocrine cells, the presence of slender cytoplasmic processes occasionally reaching the luminal surface and the paucity of specialized cells in bladder mucosa. It is unlikely that endocrine cells participate in conventional neoplasms of prostate and bladder. Exceptions are lobular hyperplasia, certain adeno-carcinomas of prostate and inverted papilloma of bladder. An ultrastructural study permitted the distinction of two types of endocrine cells characterized by a different morphology of their granules. Another relevant finding was the presence of serotonin-storing cells in Brenner tumors. The latter observation emphasizes the close similarity between this neoplastic epithelium and urothelium. This implies that endocrine cells may be of mesodermal derivation.

Brenner Tumor↗
PubMed1983

Argyrophilic cells in mammary carcinoma.

Breast tumor tissues were treated by the Grimelius procedure and examined for the presence of argyrophilic cells. Carcinomas found to contain argyrophilic cells did not include classic carcinoid tumors; the group was, in fact, heterogeneous, comprising poorly differentiated ductal carcinomas, lobular carcinomas, carcinomas of uncertain origin, and colloid carcinomas. Colloid tumors were the most frequently encountered. The prominence of argyrophilic cells in colloid carcinomas raises the possibility that development into mucin-producing cells is propitious for endocrine differentiation.

Adenofibroma↗
PubMed1983

[Merkel cell tumor].

Two cases of skin carcinoma which display endocrine differentiation are reported. In the relevant literature, these neoplasms are considered to be of Merkel cells lineage. These two carcinomas demonstrated salient morphological features. The first tumor contained small aggregates of cells with a deeply indented nucleus. It is postulated that these formations represent foci of Merkel cells maturation. It is suggested that this distinctive focal histological feature may permit recognition of these neoplasms. The second tumor exhibited an admixture of endocrine and epidermoid differentiation. Such observations prompt us to postulate that Merkel cells and keratinocytes originate from the same stem cell.

Aged↗
PubMed1980

[Demonstration of estradiol and progesterone receptors in histological preparations].

Oestradiol receptors were demonstrated using the technique of Sin Hang Lee. Receptors are seen after incubation of a section of breast tissue frozen immediately before, with oestradiol bound to a fluorescent molecule (17 beta-oestradiol-6-carboxymethyloxime-bovine serum albumin-fluorescein isothiocyanate). By the same technique, it is possible to visualise progesterone receptors (11 alpha-hydroxy-progesterone hemisuccinate-bovine serum albuminum-tetramethyl rhodamine isothiocyanate). This technique was applied routinely to all breast specimens sent to the laboratory. There were approximately 30 carcinomas, 10 fibroadenomas and 10 dysplasic lesions. Infiltrating carcinomas contained oestrogenic receptors, their distribution being heterogeneous. They appeared to consist of a mixture in varying proportions of positive and negative cells. Intracanalicular carcinomas contained little or no receptors. Receptors were present in Paget cells whilst surrounding keratinocytes contained none. Young fibroadenomas showed the presence of receptors within their epithelial and fibroblastic elements. By contrast, fibroadenomas in a state of involution were negative. Dysplasias may contain receptors, the quantity and distribution showing no typical pattern. In particular, intracanalicular epithelial proliferations may contain receptors. The results of this technique have not yet been correlated with those of "exchanges in vitro".

Adult↗
PubMedDate not supplied

[The glucagonoma syndrome. 3 new cases].

We report three new cases of glucagonoma revealed, 6 to 12 months after its onset, by non-specific and misleading skin lesions associated in all 3 cases with diabetes mellitus, severe deterioration of the general condition and hyperglucagonaemia. Non-invasive methods, such as ultrasonography and computerized tomography (CT), are most helpful to locate the pancreatic tumour. Phlebography with tiered venous blood sampling is useful in difficult cases. A false positive result has been recorded with arteriography. Ultrasonography and CT have yielded two false negative results. The alpha-chain of the chorionic gonadotrophin hormone has limited value in the diagnosis of malignant glucagonoma. Treatment is surgical, but despite it, the prognosis is severe (two of our three patients died), due to the risk of thromboembolism, to cachexia and to metastases that are frequent at the time of diagnosis.

Aged↗
PubMedDate not supplied

Microfilamentous carcinoid of the thymus: correlation of ultrastructural study with Grimelius stain.

We observed a carcinoid of the thymus that was remarkable for the presence of intracytoplasmic inclusions-readily visible by light microscopy-in the majority of tumor cells. The inclusions were best seen in Grimelius-stained preparations, which also revealed argyrophilic granules present within or close to the masses. On electron microscope examination the inclusions were found to be composed of aggregates of filaments, probably of the intermediate type, which were at times accompanied by neurosecretory granules. The observed incompatibility between the presence of such inclusions and a homogeneous distribution of secretory granules in the cytoplasm is suggestive of a dysfunction of intracellular movements. Microfilamentous carcinoids may represent a class of tumor having a pathologic excretory process.

Adult↗
PubMedDate not supplied

[Carcinoma in situ of the testis].

Carcinoma in situ (C.I.S.) of the testis is the only known precancerous lesion of germ cell tumours. The prevalence and the incidence of C.I.S. are both unknown, although predisposing factors have been identified: history of germ cell tumour of the contralateral testis, cryptorchidism or history of ectopic testis, decreased fertility or sterility. The incidence is higher in the presence of a combination of several of these factors. No complementary investigations have been demonstrated to be of any value in the detection of C.I.S. which can only be diagnosed, at the present time, by means of surgical biopsy. Once C.I.C. has developed, it never resolves spontaneously. In one half of cases the C.I.S. evolves into an invasive tumour over a period of 5 years. There is no consensus concerning the population in which testicular biopsy should be proposed looking for C.I.S. A large scale C.I.S. screening and detection programme has been proposed in Denmark. However, it is not clear that there is any major gain in testicular cancer morbidity and mortality in comparison with a surveillance programme of patients at risk. Apart from conservative follow-up, two types of treatment can be proposed: orchidectomy or external beam radiotherapy which appears to eradicate the C.I.S. while preserving endocrine function.

Carcinoma in Situ↗
PubMedDate not supplied

[Malignant fibrous histiocytoma with granular cells].

This report describes a malignant tumor of soft tissue which combined granular cells with an histologic pattern of malignant fibrous histiocytoma. Immunohistological and ultrastructural studies were performed. Neo-plastic cells were devoid of S-100 Protein but contained lysozyme. Ultrastructural findings showed granular cells containing numerous lysosomes and non-granular cells exhibiting fibroblastic and histiocytic differentiations. This lesion prompts us to consider either a malignant granular cell tumor or a malignant fibrous histiocytoma.

Aged↗