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F Fetissof

Publications and source records attributed to F Fetissof.

At least 73 records · Page 4Linked to original sources
PubMed1986

Calcitonin-secreting carcinomas of the prostate. An immunohistochemical and ultrastructural analysis.

Two cases of calcitonin-producing carcinomas of the prostate are reported. Light microscopical, immunohistochemical, and ultrastructural investigations have been performed. These tumors displayed a remarkable dual, endocrine and common epithelial (exocrine), differentiation. However, they presented two different architectural growth patterns. Of particular interest, numerous calcitonin cells were immunocharacterized. In addition, the endocrine component could harbour carcinoembryonic antigen, serotonin, human chorionic gonadotrophin, and prostate-specific acid phosphatase immunoreactive cells. Ultrastructural analysis confirmed the presence of numerous endocrine cells. These findings are not unexpected, since calcitonin, serotonin, and human chorionic gonadotrophin immunoreactive cells are normal and constitutive inhabitants of prostate gland. In the current cases, calcitonin cells showed a strong carcinoembryonic antigen immunoreactivity, as observed also in thyroidal C-cells. This peculiar kind of prostatic carcinoma might be compared to certain thyroidal tumors of intermediate type coupling parafollicular and follicular differentiation.

Acid Phosphatase↗
PubMed1986

Unusual endocervical polypoid tumor with endocrine cells: an immunohistochemical and ultrastructural analysis.

Light microscopic, immunohistochemical, and ultrastructural features of an unusual polypoid tumor of endocervix are reported. Numerous polypeptide hormone and amine-producing endocrine cells were disclosed. Main conventional characteristics were the architectural growth pattern, with infolding glands giving rise to small secondary glands, the hypermucinous benign-appearing epithelium of endocervical type, and, possibly, the stromal smooth muscle. Ultrastructural analysis showed a highly differentiated tumor. Glandular elements were surrounded by a basal lamina. Mucinous cells, several endocrine cell types, amphicrine cells, nonsecretory ciliated cells, ciliated mucinous cells, and possible reserve cells were observed. This tumor departs appreciably from normal mucosa and common varieties of endocervical polyp, particularly its distinctive endocrine profile. The present case does not correspond to a well-defined type of endocervical neoplasia. It shares morphologic analogies with mucinous tumor of ovary. The malignant potential of this lesion as well as its relationship with minimal deviation adenocarcinoma remain questionable.

Endocrine Glands↗
PubMed1986

[Postoperative vaginal pseudosarcoma. Apropos of a case].

We report a case of a pseudosarcoma in the scar of an anterior repair operation. The possibility that the lesion could be sarcomatous was raised by the histologists and by the appearance on the hysterogram of a filling defect in the fundus of the uterus which resembled a sarcomatous lesion. The patient was treated by external irradiation and total hysterectomy and colpectomy. The tumour belonged to that entity that is known under the name of "post-operative pseudosarcomatous nodule". The characteristics, clinical and histological, should be better known so that this mistake is not repeated. The treatment is just simple excision.

Aged↗
PubMed1985

Endocrine cells in median raphe cysts of the penis.

Serotonin-storing cells are distributed in all tissues derived from cloaca. They were observed in the cavernous portion of penile urethra whereas they were absent from the glans portion. Serotonin cells were detected in several morphologic varieties of median raphe cysts. It is suggested that these cysts arise from the endodermal part of urethra.

Carcinoma, Squamous Cell↗
PubMed1985

Female genital tract and Peutz-Jeghers syndrome: an immunohistochemical study.

Systematic detection of endocrine cells was performed in two genital tracts from patients with Peutz-Jeghers syndrome (PJS). These tissues proved to be particularly rich in endocrine cells. The specialized cells were distributed in the cervix and fallopian tubes. In the cervix, they were confined to remarkable mucinous tumors related to "adenoma malignum." Serotonin, somatostatin, gastrin, and pancreatic polypeptide immunoreactive cells were characterized. In fallopian tubes, serotonin-storing cells and somatostatin cells were detected respectively among normal-appearing and mucinous areas of tubal epithelium; in addition, serotonin-storing cells were found in many mesonephric rests. This strongly contrasts with the usual paucity of endocrine cells in the female genital tract. However, none of the findings mentioned was really specific of PJS. In particular, endocrine cells seem to be an integral constituent of adenoma malignum, with or without PJS. These findings suggest a disturbance of tissular differentiation.

Adenocarcinoma↗
PubMed1985

Endocrine cells in the female genital tract.

Endocrine cells are normal inhabitants of the para-urethral, Bartholin's and endocervical glands and of mesonephric rests. All these cells were characterized as serotonin-storing cells. In the para-urethral and Bartholin's glands, serotonin-containing cells were most often found in the transitional epithelium of excretory ducts. Endocrine cells participated in some pathological conditions. Abundant argentaffin cells were observed among the terminal ductules in chronic bartholinitis and serotonin-storing cells were identified in a peculiar ectocervical epithelium. Numerous serotonin-storing cells were detected in a well-differentiated adenocarcinoma of cervix occurring in a patient with the Peutz-Jeghers syndrome. Argyrophilic cells were present in cases of endometrial carcinomas; a striking feature was the demonstration of gut peptide hormones in an unusual type of endometrial adenocarcinoma. Finally, serotonin-storing cells were a constituent of Brenner tumours. It is suggested that a similar endocrine pattern may be shared by tissues originating from both Müllerian ducts and the urogenital sinus.

Bartholin's Glands↗
PubMed1985

[Tentative classification of the ultrasound symptomatology of the prostate by an anatomo-ultrasonic comparison of 34 cases].

Ultrasound and histological sections were taken of 34 prostate units removed from fresh cadavers. Ultrasonography seems to raise more problems than it solves; only 73% of the normal prostates were homogeneous under ultrasound. Ultrasonography visualized nodular structures requiring biopsy in 71% of the cases of prostatic adenoma. There were too few cases of malignant tumors in the sample to warrant a conclusion. They were highly evolved. Ultrasonography gave strong grounds for suspicion, but they could be easily diagnosed clinically.

Adenoma↗
PubMed1985

[Retroperitoneal and pancreatic mucinous tumors. Immunohistochemical study].

Examples of mucinous tumors from retroperitoneum (2) and pancreas (1) were studied. These tumors share many morphological similarities with ovarian mucinous tumour and adenoma malignum of uterine cervix. They have a similar spectrum of endocrine cells; serotonin, somatostatin, gastrin and pancreatic polypeptide cells were characterized. In nonproliferative areas was found a well-differentiated mucinous columnar epithelium with scarce endocrine cell. In more proliferative areas were found either a mucinous columnar lining with infolds and secondary glands or a less well-differentiated intestinal-type epithelium with papillary formations; both linings were well supplied in endocrine cells.

Adenocarcinoma↗
PubMed1985

[Nephroblastoma with endocrine cells. Immunohistochemical study].

A case of a nephroblastoma harbouring numerous endocrine cells is reported. Endocrine cells were immuno-characterized as serotonin and somatostatin cells. In addition, a small group of pigmented cells, probably melanin-containing, was observed. This tumor could belong to the teratoid variety of nephroblastoma.

Child, Preschool↗
PubMed1985

[Tubal choriocarcinoma: a case].

The authors report a case history of a tubal choriocarcinoma occurring in a woman of 38 years of age. This was 6 years after her second and last pregnancy and was diagnosed before operation. A summary of the complementary examinations is presented: An ultrasound showing a non-specific mass whose value therefore was somewhat limited; A hysterosalpingogram which showed an irregular tubal image suggestive of a cancer of the tube; Pelvic arteriography that made the signs of choriocarcinoma fairly clear. Discussion then developed in looking at the literature of those diagnostic features that are usually made. Most often this is by laparatomy when a ruptured extra-uterine pregnancy is suspected or when suspicion rests on a twisted ovarian cyst, a uterine fibroid, a tubo-ovarian abscess or blood in the peritoneal cavity in the third trimester of pregnancy, treatment, which is best given as a combination of surgery and chemotherapy, and pathogenic aetiology. It does seem that there are two principal mechanisms, the first being a malignant transformation of a tubal pregnancy, or a choriocarcinoma arising de novo without an ectopic pregnancy.

Adult↗
PubMed1985

[Clinically isolated discharges from the nipples. Apropos of 74 cases].

74 cases with discharge from the breasts were treated surgically by pyramidectomy and histology. The histology was studied. The causes were: 1) ectasia (55%), 2) papilloma (30%) and 3), much more rare, cancer (8%). A blood-stained discharge (31 cases, 42%) could be due to these three causes, but the 4 cancers and the 2 borderline lesions belonged to the group of blood-stained discharges. A serious discharge (17 cases, 23%) could be due to ectasia or a papilloma. A thick discharge (16 cases, 21.5%) is always due to ectasia. The lactiferous duct is treated clinically and using X-rays to outline it. X-ray diagnostic methods and cytology are used in making the diagnosis. Clusters of papillae show that there is intra-canular proliferation. The literature is reviewed and a scheme of treatment is outlined.

Adult↗
PubMed1985

[Fibroadenoma of the paraurethral glands. Immunohistochemical study].

A sub-urethral tumour presenting the architecture of a fibroadenoma and of which the tubular structures were lined with a transitional type epithelium, was described under the term of fibroadenoma of the para-urethral glands. The immunohistochemical study described contributes to bring supplementary arguments in favour of this hypothesis, in showing the presence of numerous argyrophil cells, rich in serotonin, as well as some cells marked by an anti-prostatic acid phosphatase serum. We noted also, with surprise, the presence of some rare cells stained by the anti-calcitonin serum.

Adenofibroma↗
PubMed1984

Carcinoid tumor occurring in a teratoid malformation of the kidney. An immunohistochemical study.

A case of a carcinoid tumor of the kidney that was intimately related to a mixed dysplastic and teratomatous lesion is reported. This lesion displayed focal transitional, mucinous, and endocrine differentiations. Immunofluorescence studies permit the identification of three immunoreactive products: somatostatin, glucagon, and serotonin. It is suggested that the carcinoid tumor arises from this peculiar lesion, which exhibits cells of endocrine lineage.

Aged↗
PubMed1984

[Sympathetic paraganglioma. Scintigraphic detection using a new labeled molecule, meta-iodobenzylguanidine].

Two cases of sympathetic paraganglioma are reported: one, benign, in a 20-years old woman with arterial hypertension and attacks of excessive sweating; the other, malignant and with bone metastases, in a 44-years old woman. Both were diagnosed by scintigraphy, using meta-iodobenzylguanidine as radionuclide. This new radiopharmaceutic agent has recently been introduced for the detection of phaeochromocytomas, but it seems to be a general tissue marker of catecholamine uptake and storage. Its use as a therapeutic compound may also be envisaged.

3-Iodobenzylguanidine↗
PubMed1984

Endocrine cells in the anal canal.

Endocrine cells are normal inhabitants of the anal canal. While numerous endocrine cells are distributed throughout anal ducts and crypts, few are dispersed in the anal transitional zone. All these cells were characterized as serotonin-storing cells, and this endocrine profile is quite distinctive from that of adjacent mucosae. Rectal epithelium contains serotonin, somatostatin, enteroglucagon, BPP and HPP immunoreactive cells; endocrine cells are lacking in the pectinal folds and perianal skin. It is suggested that this distinctive hormonal profile may be regarded as a specific marker of this anal territory. The same pattern is found in the fetal transitional lining of anal canal. Evidence of serotonin-storing cells in the transitional epithelium of anal glands and crypts and in the ATZ epithelium, reinforces the homology between these linings and urothelium. The presence of a similar fetal epithelium implies that ATZ epithelium in adults is not necessarily metaplastic. All derivatives of the cloaca may therefore share the same endocrine profile.

Anal Canal↗
PubMed1984

[Renal carcinoma with argyrophil cells].

A case of an unusual type of renal carcinoma is reported. The tumor had a poorly differentiated appearance with focal endocrine differentiation. Scattered argyrophilic cells were revealed by the Grimelius procedure. The relationship of this tumor to other neoplastic processes displaying endocrine differentiation is considered. The present case must be segregated from the classic carcinoid group. It belongs to the heterogeneous class of carcinoma with argyrophil cells and bears some resemblance to the atypical carcinoid.

Carcinoid Tumor↗
PubMed1984

Endometrial carcinoma of the intestinal type. A first case report.

A primary endometrial adenocarcinoma is reported that showed abundant foci suggestive of pathologically differentiated intestinal epithelium. The tumor epithelium was composed of four main cell types. Columnar cells resembled absorptive intestinal cells and displayed glycocalyceal carcinoembryonic antigen immunostaining; mucin-producing cells and a few Paneth-like lysozyme-rich cells were irregularly distributed; a massive quantity of argyrophil cells including a few amphicrine (muco-argyrophil) ones, were detected by Grimelius-Alcian blue method. Immunocytochemical evidence was obtained for the storage of serotonin, somatostatin and gastrin/cholecystokinin in some of the endocrine cells. These findings suggest that the tumor arose from a pluripotential stem cell of the glandular epithelium.

Adenocarcinoma↗