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Biomedical subjects

F Franke

Publications and source records attributed to F Franke.

At least 37 records · Page 2Linked to original sources
PubMed1987

Evolution of tumor cytogenetic aberrations and N-myc oncogene amplification in a case of disseminated neuroblastoma.

Chromosome analyses including in situ hybridization with the protooncogene N-myc were carried out at diagnosis and several times at relapse in the bone marrow cells of a girl with disseminated neuroblastoma (stage IV) at ages 9, 23, 24, and 26 months, respectively. The tumor karyotype was pseudodiploid exhibiting partial monosomy for the short arm of chromosome #1, an aberration of the short arm of chromosome #2, and double minutes at diagnosis. Further structural aberrations of chromosomes #4, #6, and #17, and homogeneously staining regions could be demonstrated at relapse. In particular, the following structural aberrations were encountered: t(1;?)(p22;?),t(2;?)(p24;?), t(4;6)(q31;q25), and a der(17q). All tumor metaphases without homogeneously staining regions contained double minutes. N-myc, normally positioned within bands 2p23-24, was found to be amplified in a homogeneously staining region on the short arm of chromosome #15 by in situ hybridization. It is speculated that the translocation t(2;?)(p24;?) might be related to N-myc oncogene activation and subsequent amplification.

Bone Marrow↗
PubMed1986

Translocation (19;?) in two stage II neuroblastomas.

Chromosomes of two abdominal neuroblastomas (stage II) from a 10-month-old male infant and a 6-year-old girl were analyzed. A modal chromosome number of 70 and 46, respectively, was found. Neither double minute chromosomes (DM) or homogeneously staining regions (HSR), nor visible structural abnormalities of chromosome #1 could be detected. However, a common aberration was found to be a translocation on the short arm of chromosome #19. After tumor resection, both children are alive without any evidence of tumor disease.

Abdominal Neoplasms↗
PubMed1986

Tumour karyotype may be important in the prognosis of human neuroblastoma.

When comparing clinical and tumour cytogenetic data on 14 neuroblastoma patients in different stages of disease we found a high incidence of 1p abnormalities (12/12), homogeneously staining regions/double minutes (9/12) and 2p abnormalities (4/12) in 12 unresectable and metastatic tumours (clinical stages III and IV). In contrast, these features were absent in clinical stage II tumours (2/2) with good prognosis. The coincidence of 1p aberrations with poor outcome of disease will be discussed.

Child, Preschool↗
PubMed1985

Metastatic neuroblastoma in an infant: translocation (1;11), deletion (2) and double minute chromosomes.

An extensive chromosomal analysis was performed in cells of primary tumour and bone marrow metastases from an 8-month-old girl with disseminated neuroblastoma prior to therapy. A modal chromosome number of 46 was found. Consistent abnormalities in the karyotype were seen: in particular, a translocation (1;11), a deletion (2)(p21) and a chromosome 7p+. Furthermore, double minute chromosomes of two distinct sizes were found in 50%-80% of metaphases in the cell populations examined. These extra chromosomal double minutes might be the cytogenetic form of amplified cellular oncogene-DNA.

Adrenal Gland Neoplasms↗
PubMed1984

[Vascular surgery in advanced age. Evaluation of risk based on 317 vascular surgery interventions in patients over 70].

The general caution in the diagnosis of elderly patients needing vascular surgery is not always founded and should remain the right of the surgeon. The selective, reconstructive vascular surgery does not have a considerably higher risk in the elderly. Depending on the localisation the mortality following revascularisation is considerably less with 3,3 to 21,1% than following the amputation of limbs with 42,5%. A further reduction in the rate of complications after reconstruction is possible due to extra-anatomical procedures and early diagnoses before irreversible damage occurs. The possibility of revascularisation should be tested in good time, particularly in elderly persons with disturbed circulation and especially before an amputation.

Aged↗
PubMed1982

[Chromosomal studies in metastatic neuroblastoma].

Chromosomes were prepared directly from primary tumor and bone marrow aspirates of an 8 months old infant and a 2 years old boy with metastatic neuroblastoma. A total of 765 tumor metaphases were counted after Giemsa-banding and partially karyotyped. "Double minute" chromosomes were found in the metaphases of both primary tumor and metastases of the infant, but only in the primary tumor of the older child. In both patients, structural imbalances (in addition to other translocations) were seen in the short arm of chromosome no. 1. The modal chromosome number was 46 in the infant's primary tumor and bone marrow metastases, but 84 in the primary tumor and 46 and over 100 in the bone marrow metastasis of the older child. Clonal evolution of metastasizing neuroblastoma cells is discussed.

Adrenal Gland Neoplasms↗
PubMed1982

[Radiological diagnosis of cavernous hemangioma of the liver (author's transl)].

Eight cases of cavernous hemangioma of the liver are described and their sonographic, scintigraphic, computertomographic and angiographic findings are discussed. The angiographic diagnosis was the most reliable, especially when the computertomography was performed without using contrast medium for tissue enhancement. In cases of doubt laparatomy was necessary in order to maintain a histological diagnosis.

Adult↗
PubMed1981

[Hepatico-jejunostomy by the R. Smith-technique for the repair of central biliary ducts (author's transl)].

In order to repair a lesion of the proximal biliary duct, a wide anastomosis without tension and without reflux of intestinal content is required. If a biliary-intestinal anastomosis is technically not possible the R. Smith-procedure may be applied. For this purpose a segment of jejunum without serosal layer is pulled over a catheter into the biliary duct and the catheter fixed outside the abdomen. 11 good long-term results and 2 recurrences of stenoses could be observed by this method.

Cholangiography↗
PubMed1980

Indications, technique, and results in 336 tibioperoneal reconstructions.

At the University of Erlangen-Nürnberg, a retrospective study was done of 336 femorotibial bypasses for limb salvage, with a follow-up of 7 years. The indication for arterial reconstruction was severe ischemia in 80.7%. Early good results were obtained in 89.6%, and the mortality rate was 1.5%. The best bypass grafts were the autologous vein and the composite graft, with patency rates of 92%. Five and 7 years after surgery, the cumulative patency rates were 50.7% and 49.1% respectively.

Journal Article↗
PubMed1980

[Surgical therapy of chronic arterial obstructions of the lower extremities in elderly patients].

The aim of this study was to determine whether arterial reconstructions in old age carry an acceptable risk and are reasonable as far as long term results are concerned. The operative mortality was 3,4% for reconstructions distal to the inguinal ligament and 20.5% for reconstructions in the aorto-iliac region. Limb amputations were fraught with a very high mortality of 38.9%.

Amputation, Surgical↗
PubMed1979

[Surgical therapy of arterial occlusions. Indication and results of revascularization in 5370 peripheral arteriosclerotic occlusions].

The results of 5370 revascularizations in peripheral arteriosclerotic occlusive diseases are reported. The operative mortality in 532 carotis interna desobliterations with ischaemia stage II was 2.3%. In stage I of 98 prophylactic operations we lost no patient. Instead of the transthoracic reconstruction we now prefer the extrathoracic bypass because of the lower risk involved. The abdominal aortic aneurysm always is an indication for resection because of the danger of rupture. In cases of 100 operated patients with aneurysm we had a mortality rate in the elective stage of 5.3%, in stage of covered rupture of 47.1% and in ruptured aneurysm 85.7%. The complications in vascular reconstruction of the lower extremity are low. The mortality rate after implantation of aortic bifemoral prosthesis is 3.7%, after an unilateral aortic-femoral prosthesis 2.8% and after all operations below the inguinal ligament 1.0%. Also the femoro-tibial occlusions could be revascularized in bypass-technique with a risk of 1.5% and good early results of 90.3%.

Aortic Aneurysm↗
PubMed1979

[Results of an altered resection in the Billroth II-resected stomach for restoration of the gastroduodenal passage].

Our indications for re-establishment of the gastroduodenal passage were complicated and intractable anastomotic ulcers (20 patients), loop- (8 patients) and dumping-syndromes (8 patients). All 36 procedures were carried out without mortality. Two additional reoperations were necessary because of one anastomotic stenosis and one recurrent ulcer. 83% (24 out of 29) of the patients, who had follow-up examinations, were free of complaints. Normalization of resorptive function by re-establishment of gastroduodenal passage could be proven objectively by normal laboratory values and an increase in body weight.

Adult↗
PubMed1978

[Operative treatment of arterial occlusive disease: the risk of operation in high age patients (author's transl)].

Comparative study of 2,168 revascularizations and 221 limb amputations at the surgical hospital of Fürth/Bavaria (1970--1977). The lethality rate after arterial reconstructions in older patients, depending on the type of revascularization, was 3.3 per cent up to 21.1 per cent, being considerably lower than after amputation after which 42.5 per cent of the patients died. Therefore vascular surgery should be considered at an early stage of the disease in older patients with problems of circulation, particularly before any limb amputation.

Age Factors↗
PubMed1978

[Revascularisation in the femoro-crural region (author's transl)].

Femoro-crural revascularisation was performed in 132 operations in 126 patients. In 85.6% of these cases the operation was indicated because stage-III or stage-IV ischaemia was present. The necessity for surgery is determined by radiography of one artery of the lower extremity; in 31 of these patients it was necessary to perform a direct femoral puncture or an exploratory vascular operation followed by angiography. The authors' policy was to perform orthotopic reconstruction with autogenous vein grafts. In isolated cases a ring clearance or a prosthesis was used in the thigh region. Immediate patency was obtained in 93.9%. Of these operations, 120 were seen as follow-up; 78.3% of the bypasses were still patent, there was occlusion in 15 cases, and amputation was necessary in 11. Long-term results (2 to 9 years after the operation) were good in 64.4%.

Adult↗