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Biomedical subjects

F Fu

Publications and source records attributed to F Fu.

At least 55 records · Page 3Linked to original sources
PubMed1994

Split tolerance induced by orthotopic liver transplantation in mice.

Spontaneous orthotopic liver allograft acceptance associated with microchimerism in mice induces tolerance to subsequent skin or heart transplants from the donor but not third-party animals. Despite in vivo hyporesponsiveness, in vitro MLC and CTL assays showed continuing antidonor reactivity. Cells isolated from recipients' spleens and grafted livers, when tested in MLC and CTL assays, were antidonor reactive out to 3 months to the same degree as splenocytes obtained from either naive or presensitized (with skin or heart) mice. Nevertheless, passive transfer of splenocytes or liver lymphocytes from liver tolerant mice, but not naive or sensitized donor strain mice, were able to prolong skin graft survival significantly in naive irradiated recipients. By using a strain combination in which the donor but not the recipient expressed the stimulatory endogenous super-Ag (Mlsf), it was possible to determine whether super-Ag-reactive T cells bearing V beta 5 and V beta 11 were deleted or anergic. Phenotypic analysis of cells isolated from recipients' spleens and grafted livers (up to 90 days after transplant), when compared with naive animals, showed no significant difference in V beta 5 and V beta 11 TCR expression. Additionally, when these isolated spleen cells were tested for antibody-mediated stimulation, both anti-V beta 5 and V beta 11 TCR mAb led to marked proliferation of cells obtained from naive and liver-transplanted recipients, but as expected, proliferation was very low in cells from naive donors. These results suggest that liver transplantation induces donor-specific tolerance in vivo, which may not be reflected in in vitro proliferative and cytotoxicity assays (split tolerance). Furthermore, this tolerance does not seem to be induced by clonal deletion or anergy of minor-lymphocyte-stimulating-antigen-reactive T cells in the recipients.

Animals↗
PubMed1994

Intraarticular contact stresses with simulated ankle malunions.

Peak contact stresses were evaluated in a human cadaver ankle model of ankle fracture malunion. In one set of experiments, changes in peak contact stresses were evaluated for ankles loaded with lateral displacements of the talus and fibula of 1, 2, 3, and 4 mm. In a second set of experiments, peak contact stresses were evaluated after removal of posterior malleolar fragments. Peak contact stresses were concentrated over the anterior medial talar dome in normal specimens, and in specimens with stimulated malunions. There were relatively low stresses beneath the medial malleolus. Peak stresses for ankles without talar displacements ranged from 1.9 MPa to 12.4 MPa (eliminating one disparate specimen). There was no increase in peak stresses with lateral displacements of the talus or with removal of posterior malleolar fragments. The fact that peak stresses with simulated ankle malunions were not elevated suggests that factors other than the magnitude of normal contact stresses are of greater importance in the pathogenesis of posttraumatic arthritis.

Ankle Injuries↗
PubMed1994

Estimation of body composition in Chinese and British men by ultrasonographic assessment of segmental adipose tissue volume.

It has been shown that ultrasonographic measurements can be used to predict body composition in adults. The purpose of this study was to assess the relationship between ultrasonograph and caliper (SKF) measurements of subcutaneous adipose tissue thickness in athletic Caucasian (English, E) and Asian (Chinese, C) men against estimates of body composition determined from hydrodensitometry (HYD). The usefulness of a proposed ultrasonographic method of estimating lean and fat proportions in the upper and lower limbs was also evaluated as a potential method of predicting body composition. Ultrasonography (US) was used to measure adipose and skin thickness at the following sites: biceps, triceps, subscapular, suprailiac, abdominal, pectoral, thigh and calf. Caliper measurements were also made at the above sites. Subcutaneous fat thickness and segmental radius were measured directly from the display screen of the ultrasonic scanner (Aloka 500 SD). By applying the geometry of a cone, the proximal and distal radii of the upper arm and upper leg were used to calculate the proportionate volumes of adipose tissue. The best correlations for US and SKF were obtained at the quadriceps, subscapular and pectoral sites for E (r = 0.96, 0.93 and 0.90, respectively) and at the quadriceps, calf and abdominal sites for C (r = 0.90, 0.81 and 0.75, respectively). The best ultrasonographic predictor of the percentage fat in both groups was the percentage adipose tissue volume in the upper leg (r = 0.83 and 0.79 for C and E, respectively). Stepwise multiple regression analysis indicated that the prediction of percentage fat was improved by the addition of the ultrasonographic abdomen measurement in both groups: Chinese sample: %fat = %fat(leg) (0.491) + US abdomen (0.337) + 0.95 ( R = 0.89, s.e.e. = 1.9%); English sample: %fat = %fat(leg) (0.435) + US abdomen (0.230) - 0.765 ( R = 0.80, s.e.e. = 3.6%). It is concluded that ultrasonographic measurements of subcutaneous adipose tissue and volumetric assessment of percentage adipose tissue in the thigh are useful estimates of body composition in athletic English and Chinese males.

Adipose Tissue↗
PubMed1993

Fat-free mass estimation by bioelectrical impedance and anthropometric techniques in Chinese children.

There is limited information on the accuracy of bioelectrical impedance analysis (BIA) for estimating body composition in children. The purpose of this study was to evaluate BIA measurements for estimating fat mass and fat-free mass in 94 Chinese boys and girls aged 11-17 years. Percent fat (%fatskf) and fat-free mass (FFMskf) were predicted by regression of skinfolds in an equation which is founded on a multicomponent model of body composition in children. Multiple-regression analyses were applied to the data to determine if height2 divided by resistance (resistance index) (RI) could accurately predict FFMskf and %fat. Correlations (R) and predictive accuracy (standard error of the estimate, S.E.E.) for FFMskf for RI alone were 0.94 and 2.7 kg; for RI and body mass this improved to 0.96 and 2.2 kg, and for estimation of %fatskf from RI and body mass these values were 0.78 and 4.7%, respectively. A previously published prediction equation, developed on Caucasian children and which also used RI and body mass, was also cross-validated with the Chinese sample in this study. There was no difference between the predicted values from this equation and FFM and %fat predicted by the skinfold technique. The correlation coefficient for FFM was 0.96 and the S.E.E. was similar to that originally reported for the Caucasian sample. We conclude that BIA is a reliable and acceptably accurate method of estimating anthropometrically determined body composition in Chinese youth.

Adipose Tissue↗
PubMed1984

Sports injuries survey on university students in Hong Kong.

A sports injuries survey was conducted among 1714 students of the Chinese University of Hong Kong. The common sports involved in injuries were Soccer (26%), Basketball (18%), Cycling (11%), Track and field athletics (11%) and Swimming (10%). The lower limb usually took the brunt of the injuries (67%) followed by the upper limb (28%) and spinal injuries were relatively uncommon (3%). The majority of the injuries were mild to moderate and the commonest ones were abrasion (37%), contusion (21%), cramp (20%), sprains (9%), and strains (7%). Of the injuries 80% recovered in less than 10 days and 50% of them were self-treated. However, a significant group of more severe injuries was recorded: fracture, concussion and heat stroke which demanded special medical attention and longer period for recovery. The pattern of treatment was also unique in that traditional Chinese methods of treatment were sought more frequently than special orthopaedic advice. The preventive aspects of sports injuries was not well recognised with only 40% of the students regularly practising warm-up exercises, 18% stretching exercises and 4% using protective aids. More educational programmes and studies were indicated. The set up of a sports injury clinic is recommended with the utilisation of a sports injury reporting system.

Adolescent↗
PubMed1982

Sun Simiao.

Explore the source record for details and available documents.

History, Medieval↗
PubMed1980

External fixation in pelvic fractures.

The treatment of unstable pelvic ring fractures, markedly comminuted and displaced acetabular fractures, and combinations of these insults to the pelvis has been an unsolved problem in orthopedics up to the present time. Of the previous methods of treatment, external fixation has appeared to hold the most promise for certain major pelvic insults, especially those accompanied by instability of the pelvic ring. Many of the previously used external fixation devices, however, have not provided adequate stability. Recently we have modified the Hoffmann external frame to provide a simple method of treatment for unstable pelvic ring fractures that permits the patient to undergo immediate mobilization from bed to chair. Certain other complex central acetabular fractures and combined insults involving the pelvic ring, central acetabulum, and proximal femur have been treated by extensive external frames. The results of these methods are described. Although such external devices appear to be superior to previously available methods, nevertheless, in view of their inherent limitations, we have begun to explore possible methods of internal fixation of the posterior portion of the disrupted pelvic ring combined with internal or external fixation of the anterior segment of the pelvis.

Adolescent↗