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Biomedical subjects

F G Taylor

Publications and source records attributed to F G Taylor.

36 records · Page 2Linked to original sources
PubMed1989

The effect of titanium dioxide inhalation on the pulmonary clearance of Pasteurella haemolytica in the mouse.

Four inhalation exposure chambers were designed and built in which up to 80 mice per chamber could be accommodated. Exposure for several weeks to an inert inorganic particulate aerosol of titanium dioxide at a respirable aerosol concentration of 20 mg m-3 impaired the clearance of Pasteurella haemolytica in proportion to the duration of exposure. Other groups exposed to a lower respirable concentration of 2 mg m-3 exhibited similar clearance rates relative to mice maintained in clean air. A recovery experiment showed that inhalation of TiO2 at 20 mg m-3 for 10 days impaired bacterial clearance at least 10 days after cessation of exposure to TiO2.

Administration, Inhalation↗
PubMed1989

Pulmonary clearance of Pasteurella haemolytica and immune responses in mice following exposure to titanium dioxide.

The effects of dust inhalation on immune responses in mice to aerosolized Pasteurella haemolytica were investigated. Animals exposed to titanium dioxide dust (TiO2) at a respirable aerosol concentration of approximately 20 mg m-3 for 20 hr per day, before or after aerosol vaccination, had impaired pulmonary bacterial clearance relative to animals kept in clean air. Additionally, lymphocytes from the local (mediastinal) lymph nodes had depressed responses to bacterial antigen in vitro in mice exposed to dust immediately after vaccination. However, there were no differences in the splenic lymphocyte responses between groups, while serum antibody responses were low and variable. A second experiment showed that aerosol vaccinated and nonvaccinated animals, which were exposed to a respirable aerosol concentration of TiO2 at 20 mg m-3 immediately after inoculation with a bacterial aerosol, had impaired clearance compared to their respective controls maintained in clean air.

Aerosols↗
PubMed1989

Fever of unknown origin in the horse: a review of 63 cases.

Fever of unknown origin (FUO) is a syndrome characterised by prolonged, unexplained fever associated with non-specific signs of illness such as lethargy, inappetence and weight loss. This paper reviews the details of 63 horses affected by FUO. The cause was found to be infection in 43 per cent of the cases, neoplasia in 22 per cent, immune-mediated diseases in 6.5 per cent and miscellaneous diseases in 19 per cent; the cause remained undiagnosed in 9.5 per cent.

Animals↗
PubMed1988

Generalised steatitis in an adult pony mare.

Equine steatitis is a rare condition which is usually reported in foals. A case of generalised steatitis in an adult pony mare is described and compared with steatitis in other species. It is concluded that the condition resembled that recorded in foals but that its aetiopathogenesis remains obscure.

Adipose Tissue↗
PubMed1987

Salinomycin poisoning in horses.

Six cases of accidental salinomycin poisoning in horses are described. The horses were fed a contaminated ration and presented clinical signs which were extremely varied in nature and severity. However, the range of signs, including anorexia, colic, weakness and ataxia bore similarities to those described in horses poisoned with the related ionophore monensin. Other similarities became apparent in serum biochemical profiles of the clinical cases. Although ionophore toxicity is rarely reported in horses they appear to be particularly susceptible, and it should therefore be considered as a differential diagnosis of digestive upsets or locomotory disorders at establishments where ionophore-treated feeds are used therapeutically in other species.

Animal Feed↗
PubMed1987

Clinical hypersensitivity to specific aerosol challenge in parenterally immunized calves.

This paper reports an experiment designed to demonstrate that the calf lung can be sensitized to a specific respirable challenge following parenteral immunization with a nonliving antigen (human serum albumin). The possibility that immune-mediated injury could subsequently interfere with nonspecific mucosal defenses was also investigated by infecting calves with Pasteurella haemolytica after the antigen challenge and assessing pulmonary clearance of the organism. The results indicated that specific aerosol challenge produces reversible signs of respiratory hypersensitivity and that persistence of incidental infection in the upper respiratory tract is potentiated. Since the calves were sensitized by an immunization regime which imitated conventional vaccination, this study highlights the potential dangers of inactivated parenteral respiratory vaccines.

Aerosols↗
PubMed1985

Enhanced lung clearance of antigen in immunised mice.

A mouse model is described which enables a semi-quantitative assessment of antigen clearance from the lung. The distribution of antigen presented to the non-sensitised lung is examined and shown to be reproducible using a simple in vivo inoculation technique. Preliminary studies demonstrate that antigen clearance is significantly enhanced after parenteral immunisation and that the effect is antigen specific. Applications of the model to further studies of respiratory challenge are suggested.

Animals↗
PubMed1985

Effect of aerosol challenge on a population of free lung cells in parenterally immunised calves.

There is concern that parenteral respiratory vaccines may potentiate lung disease rather than protect against it. In vivo indicators of inflammation in calves were assessed to determine if vaccine-mediated inflammation occurs in the lung following aerosol challenge of parenterally immunised subjects. Preliminary results using a simple protein antigen suggest that changes in the free cell populations of the lung are likely to be a more sensitive indicator of immune-mediated inflammation than clinical parameters or peripheral changes in serum complement.

Aerosols↗
PubMed1983

Comparison of sensitivities of ELISA and radioimmunoassay for detection of class-specific antibody in mouse serum.

The limits of detection of IgG1 antibody in a standard mouse antiserum by a single antiglobulin enzyme-linked immunosorbent assay (ELISA) and 2 amplified systems, a double antiglobulin ELISA and a double antiglobulin radioimmunoassay (RIA), were compared in microtitration plates with the same antigen preparation and antisera. Compared with the single antiglobulin ELISA, both amplified assays demonstrated a 64-fold increase in sensitivity for the detection of antibody at high dilutions of standard antiserum. It is concluded that the amplified ELISA offers a safer assay than the amplified RIA and of equal sensitivity for comparable consumption of antisera.

Alkaline Phosphatase↗