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Biomedical subjects

F Gold

Publications and source records attributed to F Gold.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Poisoning by externally-administered ethanol in an infant].

The occurrence of unexplained coma in a 15 day-old infant led to suspect an intoxication. Major ethanol poisoning (alcohol blood level: 4.4 g/l) was thus discovered in this child treated with alcohol-containing dressings. Symptomatic treatment alone resulted in favourable evolution of coma in a few hours. Half-life of alcohol was shown to be 17 hours in this child. The interest of the case reported is to remind of the dangers of percutaneous absorption of some products, especially in young infants and the importance of toxicological investigations in children with unusual manifestations of unknown etiology.

Alcoholic Intoxication↗
PubMed1981

Enterobacteria of the neonate. Normal colonization and antibiotic-induced selection.

Enterobacterial digestive tract colonization of neonates under different conditions during their first days of life was studied. Our objective is to determine the frequency of antibiotic resistance under different conditions (hospitalized newborns treated or not with antibiotics, newborns in a maternity unit, mothers treated or not) thereby permitting a better appreciation of the role played by the 'selection pressure' created by antibiotics commonly used in perinatology. The method used was the culture of graded newborn fecal dilutions on selective media, some of which contained antibiotics. Cultures were made every day during the 1st week and 2 weeks of age. By using this technique, enterobacteria can be quantified as a function of their variety and of their resistance to different antibiotics. In the normal neonate under the normal conditions, the most predominant enterobacterium is an Escherichia coli sensitive to antibiotics; these infants also had several varieties of resistant enterobacteria, frequently acquired from their mothers. An antibiotic treatment of the mothers following delivery had no effect on the enterobacteria of the newborns. In a hospital setting, treated neonates rapidly acquired resistant species of enterobacteria. Nontreated neonates, initially often colonized with sensitive enterobacteria, acquired resistant enterobacteria during their first days of life.

Anti-Bacterial Agents↗
PubMed1980

Separation and characterization of Menhaden hemoglobin components.

Hemolysate from Brevoortia tyrannus (Atlantic Menhaden) consists of two major and two minor components, as determined by ion-exchange chromatography. Oxygen equilibria, flash photolysis and rapid mixing techniques are used to detect functional differences between the two major components, revealing a system analogous to the Trout I-IV system. Menhaden IV exhibits a moderate Root effect and is sensitive to organic phosphate inhibition. Menhaden I exhibits little sensitivity to pH changes or the presence of organic phosphates. These differences are probably based on contrasting kinetic behavior, subunit heterogeneity and replacement of a COOH-terminal histidine residue. Theories accounting for the significance of functional hemoglobin multiplicity are reviewed. By bypassing the normal physiological unloading mechanisms, Menhaden I may be functioning as an oxygen reservoir, perhaps for red muscle during periods of high activity.

Animals↗
PubMed1980

[Effect of antibiotic therapy in the mother on the colonization of the newborn by enterobacteriaceae (author's transl)].

Two studies were undertaken to determine the effect of antibiotic therapy in the mother on the enterobacteriaceae of the newborn's fecal flora. In the first, mothers were given tetracycline after delivery. Although the effect on the maternal flora was important there was no noticeable effect on the enterobacteriaceae of the newborn although the organisms were predominantly susceptible. In the second, mothers were given ampicillin before delivery and resistant enterobacteriaceae were predominant in all the newborns. In the controls born to untreated mothers susceptible organism still predominate. Antibiotic treatment of the mother has an important effect on the newborn's flora if the treatment is given before delivery.

Ampicillin↗
PubMed1980

[Mycotic aneurysm of bronchial artery. Apropos of a case in an infant].

The authors report the case of a 15 day old neonate presenting a beta hemolitic streptococic (group A) infection, followed by cardio-respiratory failure and radiological opacification of the left superior lobe associated with ventilatory troubles at the left lung base. Massive hemoptysis made an angiographic study mandatory with the diagnosis of a mediastinal vascular tumor placed besides the left descending aorta with compression of the left bronchovasculary pedicule. Tumor ressection was not possible during surgical exploration and a left superior lobectomy was performed. Histological examination showed pulmonary infarctus. The child died a few weeks later. Autopsy revealed mycotic arterial aneurysm of the superior bronchic artery, a very rare lesion considering its localisation and the age of the patient.

Aneurysm, Infected↗
PubMed1979

[Value of the intravenous route for the use of phenobarbital in asphyxiated full term newborn infants].

Phenobarbital (20 mg/kg) was given intravenously to asphyxiated full term neonates who were less than 48 hours old. Further doses were given for 4 days (5 mgs/kg/d). Plasma levels were within the therapeutic range from 5 to 36 hours after the first injection but the maintenance dose always resulted in overdose by 5th day. The exact maintenance dose needs to be determined.

Asphyxia Neonatorum↗
PubMed1979

[Monitoring of intracranial pressure in 2 severe cases of Reye's syndrome].

The intracranial pressure (PIC) of two children with Reye's sundrome aged 9 years 7 months and 4 years 7 months was monitored for 9 and 5 days respectively with a subdural device. This provided a useful guide to the treatment that was necessary to reduce the very high intracranial pressure. One of the patients died of uncontrollable raised intracranial pressure (HIC). This monitoring technique should be used in all cases of HIC.

Child↗