Biomedical subjects
Publications and source records attributed to F H Linthicum.
The histopathological changes in the temporal bones of three deceased donors individuals, two with concomitant acoustic tumors and one with concomitant petroclival meningioma have been studied. The differences between neuromas and meningiomas are examined. The different clinical relevance and the different therapeutic guidelines are discussed.
The histopathological changes in the temporal bones of one donor individual deceased for complications of neurofibromatosis type 2 are studied. The different modalities of presentation of neurofibromatosis and the criteria for the differential diagnosis are presented. The possibilities of the auditory brainstem implants in this pathology are discussed.
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We used computer techniques to reconstruct in three dimensions 12 vestibular nuclear complexes (VNC) from serially sectioned brains of 7 patients. Specimens were from 4 patients with vestibular disorders and 3 patients considered vestibular normal. Despite the variety of the patient's otologic histories all the nuclei demonstrated the same shape and structural characteristics.
The English literature on the incidence of nystagmus in normal subjects and in patients with head and/or neck injuries is reviewed. The authors present a series of 202 patients with alleged vestibular trauma. The incidence of spontaneous and positional nystagmus would seem to be no greater in patients with alleged vestibular trauma than that found in the normal subjects, suggesting that these patients do not have objective evidence of vestibular trauma. Objective criteria for diagnosing vestibular abnormalities by electronystagmography are presented. At least 22% of a series of 2408 patients were found to have a functional hearing loss. The importance of looking for functional overlay in patients involved in litigation cases is stressed.
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The death in 1976 of a patient who had a multiple-electrode cochlear implant in one cochlea and a single-electrode cochlear implant in the other provided a unique opportunity for both clinical and histological study of the effects of such implants in a human an subject. The patient was 68 years old at the time of his death. In 1969, at the age of 61, and after 11 years of profound deafness, apparently as a result of lues, the patient was implanted on the left side with a hard-wired 5-wire multiple-electrode cochlear implant. Five years later, his right side was implanted with a single-electrode induction coil cochlear implant. Audiological and psychoacoustic studies were performed by a number of investigators. The results are reviewed. Following the patient's death, his temporal bones were obtained and examined using microdissection techniques followed by serial sectioning. The histological findings are described.
Temporal bones from four patients with capsular otosclerosis were examined by microdissection. Otoconia and abnormal crystalline deposits were studied by scanning electron microscopy and x-ray analytical methods. One patient showed more or less symmetrical invasion of the basilar membrane and osseous lamina by connective tissue from thickened endosteum adjacent to the larger anterior foci. In one ear sensorineural degeneration was circumscribed; in the other it was extensive and associated with cochleosaccular hydrops. Two other patients were deaf, with severe sensorineural degeneration; one had multiple active foci and evidence of cochleosaccular hydrops. In the fourth patient, who had small anterior foci, no specific inner ear pathology was found related to otosclerosis. In the hydropic labyrinths, apatite was present as abnormal deposits in the cochlear duct and as rigid crusts replacing the otoconia. Apparently these changes had been associated with abnormal labyrinthine fluid dynamics rather than with the otospongiotic process per se.
Sixty cases comprising 95 ears were reviewed in which myringotomy with ventilation tube insertion had been performed for alleviation of middle ear effusion and for which tympanometric and pure-tone audiometric data had been collected within five days of surgery (mean = 1.0 days). Results suggest that types B and C tympanograms in combination with greater than 15 dB air-bone gaps are good indicants of thick fluid in children less than nine years old. No tympanometric patterns in combination with air-bone gap data systemactically predicted thin fluid. For all subjects, type C tympanograms with less than 15 dB air-bone gaps indicated an absence of significant fluid at surgery.