Biomedical subjects
F H Rampen
Publications and source records attributed to F H Rampen.
Frequency of moles as a key to melanoma incidence?
Subjects with light skin complexion are especially prone to develop melanoma. Furthermore, individuals with large numbers of moles are also at increased risk of developing melanoma. We studied the association between these two markers of melanoma in a group of healthy white people: 116 children 6 to 9 years of age, 78 children 10 to 13 years of age, and 133 medical and nursing students 18 to 30 years of age. Moles were counted on the chest, back, and lower legs. Skin complexion was established with the use of a scoring system based on burning/tanning ability, eye and hair color, and freckling tendency. A multifactorial statistical analysis was performed. Average mole counts increased with age (p less than 0.0001). Male subjects had more nevi on the trunk than female subjects, whereas counts on the lower legs were higher in female than in male subjects (p = 0.0001). Skin complexion was an important denominator of mole proneness; subjects with a light complexion had higher mean counts than those with a dark complexion (p = 0.0001). The present study shows that a significant association exists between skin complexion phenotype and numbers of moles. The pattern of the appearance of pigmented nevi roughly correlates with the sex and site distribution of melanoma.
Does biopsy type influence survival in stage I melanoma?
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How "fine" is incisional biopsy of melanoma.
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Acetylation phenotype and skin complexion.
The relationship of acetylation phenotype to skin complexion was studied in 155 healthy Caucasians. Individuals received 500 mg sulphadimidine at 11.00 p.m.; urine was collected eight hours later. The percentage of acetylated sulphadimidine in urine was measured with high performance liquid chromatography. There was a slight but insignificant preponderance of slow acetylators in the dark skin types. It is concluded that slow acetylation phenotype is not correlated with light skin complexion. Therefore, it is unlikely that acetylation of xenobiotic carcinogens plays a dominant role in melanoma risk.
[Consensus melanoma of the skin].
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[Comparative clinical study of pyogenic granuloma and amelanotic melanoma of the skin].
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Hypertrichosis: a side-effect of PUVA therapy.
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Punch biopsy of melanoma.
A 46-year-old albino woman is described with a melanoma on the leg from which a punch biopsy specimen was inadvertently taken. In the reexcision specimen, two biopsy wounds were recognized that were filled with tumor. The initial level III lesion had to be subsequently reported as a deep level IV amelanotic melanoma with an increased thickness. It is emphasized that in places where the subcutaneous fat is absent, punch or incision biopsy may thwart proper secondary excision.
Vascular lesions in pregnancy; a hypothesis.
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Biopsy and survival of malignant melanoma.
Primary excisional biopsy is recommended as the procedure of choice whenever there is any suspicion of malignant melanoma. Evaluation of the total architecture of the lesion is necessary to make a satisfactory pathologic diagnosis and prognosis. Moreover, the risk of local tumor recurrence and metastatic potential can be increased by incisional procedures. Awareness of these potential hazards should provoke reappraisal of management of primary melanomas.
Metastatic melanoma of the brain after spontaneous regression of the primary.
A 37-year-old man is described who presented with a large cerebral mass which proved to be a metastasis from a malignant melanoma. The primary tumour was most probably located on the scalp and regressed completely after trivial traumatization one year prior to CNS involvement.
Levodopa and melanoma: three cases and review of literature.
Three patients are reported who developed a melanoma while taking levodopa for Parkinson's disease. There were two cutaneous melanomas and one metastatic melanoma with occult primary. The literature on the association of Parkinson's disease, levodopa therapy and melanoma is reviewed. The capacity of levodopa to induce melanomas and its alleged adverse effect on the clinical course of the disease are questioned.
Towards a rational perfusion strategy for malignant melanoma.
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At least one centimetre for each millimetre.
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[A patient with Sweet's syndrome].
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[Topical antibiotics in acne?].
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Female sex is a risk factor for satellite and in-transit recurrences from cutaneous melanoma.
The presence of satellite and in-transit (SIT) metastases was investigated in 388 patients with cutaneous melanoma of the extremities, registered between 1956 and 1980. Out of 99 males 20 showed evidence of SIT lesions at the time of diagnosis or during follow-up, compared with 78 out of 289 females (P less than 0.05, allowed for clinical stage). The difference is even more striking if we consider that female patients had more favourable prognostic tumour characteristics than males.