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Biomedical subjects

F J Zlatnik

Publications and source records attributed to F J Zlatnik.

At least 37 records · Page 2Linked to original sources

Comparison of amniotic fluid optical density, L/S ratio and creatinine concentration in predicting fetal pulmonary maturity.

The optical density of amniotic fluid at 650 nm (OD650) has been proposed as a rapid means of assessing fetal pulmonary maturity. Two hundred eighty-two amniotic fluid samples were analyzed for OD650, L/S ratio and creatinine concentration, and those values were related to the infants' pulmonary outcome. Among those infants delivered within 72 hours of amniocentesis, pulmonary maturity was predicted accurately in 98.3% by the OD650, 97.7% by the L/S ratio and 97.6% by the creatinine concentration. All three tests were unreliable in predicting pulmonary complications when the tests revealed pulmonary immaturity. OD650 values were found to vary inversely with centrifugation speed, reaffirming the need for standardized processing techniques to achieve reliable results. Marked discrepancies occurred between the diagnoses given by three neonatologists asked to retrospectively evaluate the likely etiology of pulmonary problems in nine infants suspected of having respiratory distress syndrome.

Adolescent↗

Radiologic appearance of the upper cervical canal in women with a history of premature delivery.

The aim of this study was to compare the radiologic appearance of the upper cervical canal at hysterography between a group of women with a history of premature delivery and a control group. A standardized technique was used that corrects for the magnification inherent in taking measurements directly from the x-ray films. Some women with a history of premature delivery had abnormally wide upper cervical canals in the nonpregnant state. Premature labor might not have been an acute pregnancy-specific event in those women but might have been a reflection of an underlying abnormality.

Cervix Uteri↗

Amniocentesis in the identification of inapparent infection in preterm patients with premature rupture of the membranes.

Twenty-nine preterm patients with premature rupture of the membranes who were not in labor and who did not have clinical chorioamnionitis underwent successful amniocenteses. Nine fluids were positive for bacteria. Subsequent clinical chorioamnionitis and shorter latency periods were more common in these 9 patients than in the 20 with sterile amniotic fluid. Positive fluids were more likely to be obtained from patients tapped within 48 hours of membrane rupture. In most patients with heavy bacterial growth, clinically apparent infection and/or labor soon supervened.

Amniocentesis↗

Dietary protein in pregnancy: effect on anthropometric indices of the newborn infant.

The urinary urea nitrogen/creatinine nitrogen ratio (UN/CN), an objective index of the level of dietary protein, was measured serially throughout pregnancy in 870 women. The mean UN/CN ratio was calculated for each subject. Subjects were grouped by mean UN/CN ratios. Those in the lowest decile (mean protein intake, 0.7 gm/kg/day) in comparison with those in the highest decile (mean protein intake, 1.5 gm/kg/day) were of lower socioeconomic class, weighed more before pregnancy, and gained less during pregnancy. However, birth weight and other anthropometric indices of the newborn infant were not related to the level of dietary protein during pregnancy.

Adult↗

Reported sexual behavior in late pregnancy. Selected associations.

The time intervals prior to delivery both for the last reported sexual intercourse and for the last reported orgasm were considered in terms of several variables in 413 puerperas. Although there were no significant differences in the reported time of last intercourse in terms of any of the demographic factors studied, orgasm in the absence of intercourse (reported events within seven days of delivery) was relatively more common and intercourse in the absence of orgasm relatively less common in study subjects with more years of formal education (p less than 0.01). Reported sexual behavior did not differ in respect to the length of gestation at delivery, selected pregnancy complications or the immediate condition of the newborn.

Coitus↗

Urinary urea nitrogen ratios: further observations.

The urea nitrogen/total nitrogen (UN/TN) and urea nitrogen/creatinine nitrogen (UN/CN) ratios in urine were compared as indicators of recent protein intake in pregnant women. The UN/CN ratio more accurately predicted recent dietary protein levels. The effects of other factors, including diabetes mellitus, on the UN/CN ratio were investigated. The UN/CN ratio is a simple and effective means of determining recent protein intake in the pregnant woman.

Creatinine↗

Dietary protein and human pregnancy performance.

Low birth weight is an important predictor of neonatal mortality and morbidity. Women of low socioeconomic classes give birth to disproportionate numbers of low-birth-weight infants and eat poorer diets than those of higher classes. Although maternal weight gain in pregnancy is positively associated with birth weight, and although animal studies demonstrate the important effects of protein restricti-n on reproductive performance, the significance or lack thereof of diet in general and of protein intake in particular in pregnant women in generally well-nourished populations has not been established. The conflicting data on human pregnancy performance and diet are critically reviewed.

Animals↗

Urinary nitrogen excretion as related to dietary protein in pregnant women.

The amount of urea in the urine acutely decreases when dietary protein is restricted. This change in urinary urea nitrogen can be represented satisfactorily by the urea nitrogen/total nitrogen (UN/TN) ratio or the UN/creatinine nitrogen (UN/CN) ratio. These determinations are apparently effective tools for simply and objectively describing the recent protein intake of pregnant women.

Ammonia↗

Human placental lactogen: a predictor of perinatal outcome?

Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perinatal outcome variables evaluated. Further analysis revealed that this was true both for the normal and abnormal pregnancy groups. Our data do not support the routine use of antepartum hPL screening, as advocated by others, as a means of improving perinatal outcome. In certain at-risk patients, there was an association between low hPL values and the presence of 1 or more of the adverse outcome variables. However, these patients had been recognized clinically as having fetuses in jeopardy.

Female↗

hPL: physiologic and pathophysiologic observations.

Serum human placental lactogen (hPL) levels were studied in 806 women in late pregnancy. The hPL levels were positively correlated with birth weight but were unrelated to maternal age, parity, socioeconomic status, or the sex of the newborn. The hPL levels peaked at 37 weeks' gestation and then declined moderately. An individual's hPL levels in late pregnancy are quite constant week to week. Patients with severe chronic hypertension have low hPL values; those carrying twins have high values.

Birth Weight↗

Low 'gynecologic': an obstetric risk factor.

The records of patients who were 17 years of age and younger at delivery were reviewed in order to ascertain whether or not a patient's gynecologic age (GA, defined as chronologic age minus age at menarche) independently relates to pregnancy risk. Low GA in a pregnant adolescent increases the chance of delivery of a low--birth weight infant. However, pre-eclampsia and other pregnancy complications studied were not related GA.

Adolescent↗