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Biomedical subjects

F K Sanders

Publications and source records attributed to F K Sanders.

At least 19 recordsLinked to original sources
PubMed1981

Shared interspecies antigenic reactivities among hamster and feline oncoviruses.

Group-reactive antisera against the major internal protein p30 of the hamster sarcoma virus (HaSV) showed interspecies reactivity in immunodiffusion even with sera of low titer against HaSV. Antisera were prepared by sc injection of virus into male New Zealand White rabbits. The cross-reactivity between interspecies antigens of feline and hamster RNA tumor viruses was stronger than between either virus with murine leukemia virus. Molecular hybridization data, obtained from nucleic acid hybridization between the viral RNA's and complementary DNA's of murine and feline oncovirus origin, were consistent with the immunologic results. THe implications of these observations were discussed.

Animals↗
PubMed1977

Experimental carcinogenesis: induction of multiple tumors by viruses.

Many viruses are able to cause the development of tumors when inoculated into suitable vertebrate hosts. Among them, polyoma virus can induce tumors in several mammalian species: not only many different kinds of tumor, but a large number of tumors within a single individual. Tissue culture studies employing cells from mice and hamsters, as well as observations of the manner of tumor development following polyoma virus injection in these species in vivo, suggest that some, or all, of the tumors so induced are multiple primaries. Because of the availability of mice of different genetic constitutions, the relative ease with which mouse cells from both normal and malignant tissue can cultivate in vitro, the known responses of mice to many carcinogenic agents, as well as the availability of transplantable, metastasizing mouse tumors, it is believed the polyoma virus/mouse host system would provide a highly suitable model in which an experimental approach to the elucidation of mechanisms for the origin of multiple tumors would be possible.

Animals↗
PubMed1972

Theta particles: a structure found in hamster sarcoma virus.

Hamster sarcoma virus (HaSV), a ribonucleic acid tumor virus, pelleted from tissue culture fluid manifests type C morphology by electron microscopy. However, if virus is first concentrated by polyethylene glycol or ammonium sulfate followed by density gradient banding, the virus shows a dramatically atypical barred core structure, termed "theta particles." This structure suggests a condensation of the ribonucleoprotein into a flat disc. Atypical particles are found with HaSV and not in similarly treated feline leukemia virus or Rauscher-murine leukemia virus. Differences in the composition of HaSV as compared with these other viruses may be responsible for the production of such particles.

Ammonium Sulfate↗