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F Kósa

Publications and source records attributed to F Kósa.

At least 19 recordsLinked to original sources
PubMed2005

New forensic anthropological approachment for the age determination of human fetal skeletons on the base of morphometry of vertebral column.

The anthropometrical study was carried out on 107 human fetal/newborn skeletons (54 male, 43 female, and 9 of unknown sex). The age of the individuals ranged from 4 to 10 lunar months. Each fetal or newborn vertebral region (cervical, thoracal and lumbar) has its own distinguishing features that are easily identifiable even in fragmentary bones. With our large sample size and extension of the age range studied, we are able to determine the fetal age with a considerable degree of accuracy from measurements defined in the vertebral ossification centers using regression equations. A simple rapid method for the identification and classification of fetal vertebral column bones has been contributed. The identification and classifications were carried out using discriminant functions. Knowledge of changes in vertebral column bones during fetal development is important in applied contexts of forensic and anthropology researches.

Age Determination by Skeleton↗
PubMed2001

Estimation of fetal age from dimensions of atlas and axis ossification centers.

The atlas and axis ossification centers of 106 human fetal and neonate skeletons were measured. The skeletons belong to the collection in the Department of Forensic Medicine of the Albert Szent-Györgyi Medical University, Szeged, Hungary. The age of the skeletons ranged from 4 to 10 lunar months. Nine linear measurements on the atlas, seven on the axis neural arches ossification centers and three on each one of the axis centra ossification centers were taken. We did simple and multiple linear regression analysis to estimate the age of fetuses. The results show that it is possible to use regression equations to estimate the fetal body length and age from atlas and axis ossification centers measurements during the whole period of development studied. The study of size and shape of the ossification centers using factorial analysis (principal component analysis) shows that the shape of the dens of the axis might be useful to estimate fetal viability.

Age Determination by Skeleton↗
PubMed2001

A multivariate method for classifying third to seventh cervical newborn vertebrae using bone measurements.

This research provides a method to classify human newborn (9 to 10 lm) third to seventh cervical ossification centers. Nine linear measurements on the cervical neural arch were defined from 35 human neonates. Four discriminant functions were performed using the stepwise method. The model classifies 82.8% of grouped cases and 77.9% of cross-validated cases correctly. The model is useful in cases with isolated or commingled remains during anthropological or forensic investigations.

Cervical Vertebrae↗
PubMed1999

Morphology of the cervical vertebrae in the fetal-neonatal human skeleton.

The gross anatomical features of human cervical vertebrae during the fetal-neonatal period were investigated in order to develop morphological standards for the individual ossification centres for use in forensic and anthropological osteology. It was found that the morphology of the cervical vertebral arches and the centra cannot be used for the determination of fetal age although the dens of the axis displays some developmental differences which may be useful for the determination of fetal maturity.

Cervical Vertebrae↗
PubMed1999

Calculation of percent shrinkage in human fetal diaphyseal lengths from fresh bone to carbonized and calcined bone using Petersohn and Köhler's data.

Calculation of age from fetal and newborn remains may be problematic, and when these remains are altered by maceration, decomposition or burning, age may be more difficult to discern. When soft tissue indicators are transformed, then two techniques exist for accurate age determination; dental development, which may prove difficult given the degree of tissue alteration; and appearance, size and fusion of ossification centers, including diaphyseal length, which may yield inaccurate ages if shrinkage is not accounted for. This study is undertaken to facilitate age calculation by systematically re-evaluating diaphyseal shrinkage and determine shrinkage rates from wet to carbonized states and wet to calcined states using Petersohn and Köhler's data, originally published in German and then published in Fazekas and Kósa (1978:362-369). Average shrinkage, standard deviation, minimum and maximum values are calculated for each diaphysis and then for all diaphyses between 4-10 lunar months (LM) and for newborns. Associated values for carbonized diaphyses are: 4 LM--32.50% +/- 12.12%; 5 LM--14.04% +/- 4.44%; 6 LM--6.78% +/- 1.06%; 7 LM--4.18% +/- 0.31%; 8 LM--3.47% +/- 0.42%; 9 LM--3.05% +/- 0.18%; 10 LM--2.46% +/- 0.67%; and in newborns 2.16% +/- 0.29%. Similar values for calcined diaphyses are: 4 LM--40.11% +/- 17.51%; 5 LM--18.29% +/- 4.42%; 6 LM--9.84% +/- 1.27%; 7 LM--9.82% +/- 0.51%; 8 LM--9.42% +/- 0.72%; 9 LM--9.45% +/- 0.33%; 10 LM--8.94% +/- 0.37%; and in newborns 8.96% +/- 0.49%. These findings suggest that percent shrinkage due to carbonization and calcination is greatest in the earliest age groups, decreasing substantially with advancing age. The rates of shrinkage, however, vary by the burning process utilized and age group studied. These general findings are similar to those of Petersohn and Köhler, yet specific values for percent shrinkage vary greatly from values cited in this analysis. These data provide a means to assess the degree of shrinkage that occurs for each diaphysis for each given age group.

Age Factors↗
PubMed1994

Early transient suppression of c-myb mRNA levels and induction of differentiation in Friend erythroleukemia cells by the [Ca2+]i-increasing agents cyclopiazonic acid and thapsigargin.

Cyclopiazonic acid and thapsigargin, inhibitors of the endoplasmic reticulum Ca2+ pump were shown to elevate [Ca2+]i in Friend erythroleukemia cells, line F4-6, at concentrations of 1-5 microM and 0.5-2 nM, respectively. At the same concentrations, these agents induced a strong suppression of c-myb mRNA levels within 3 h, whereas c-myc expression remained unaffected. The c-myb expression recovered and approached pretreatment levels at 9-12 h of incubation. The decrease in c-myb mRNA was prevented in Ca(2+)-free medium. Treatment of F4-6 cells with EGTA led to a transient increase in c-myb mRNA with the same kinetics as the Ca2+ pump inhibitor-induced suppression, indicating that c-myb expression is bidirectionally regulated by changes in [Ca2+]i. Studies on the differentiation status of F4-6 cells following cyclopiazonic acid or thapsigargin exposure demonstrated a marked increase in beta-globin mRNA synthesis at 60h and in hemoglobin production at 96 h. These results provide further evidence that a rise in the cytosolic Ca2+ concentration is capable, in Friend erythroleukemia cells, of inducing an early transient suppression of c-myb mRNA levels, which is followed by terminal erythroid differentiation.

Animals↗
PubMed1993

Juvenile delinquency and drug dependence in Hungary.

It is regretable that the delinquency has increased in Hungary over the past 15 years. This fact occurred because criminality increased to a greater extent than average, and this means a steady supply of adult criminals. According to the surveys of the forensic psychiatrical records carried out over the 4 years between 1987-1990 in archival material of our Department, the criminological factors which occurred most frequently in juvenile delinquency among the 14-18-year-old age group are immature personality, endangered family background and inadequate school attendance. Thirty percent of criminal acts could be connected with alcoholism, 65% with theft, and 22% with aggressive delinquency. An important role in the increasing juvenile delinquency must be attributed to the crisis of the previous regime, including the faulty endeavours in child and youth protection and the inefficient school system. The decrease in living standards and the employment of women in work contributed to the loosening of family relations and the dereliction of children's education. The proportion of institutional young people among the perpetrators is high. Another factor with regard to the disadvantageous situation is the migration of young people to the towns from villages. Without the necessary conditions and with the poor company of friends, this presents an intensified criminological danger. Prevention is obviously of outstanding importance. The improvement of the economic situation, stability of families, substantial changes in school reform, the fight against alcoholism and the modern judicial regulation can be the means to achieve this goal.

Adolescent↗
PubMed1989

[Microprobe study of bones in the determination of individual age].

Potassium and phosphorus levels and the Ca: P ratio were determined in autopsy material taken from the compact bone substance of the right femur of 25 individuals of various age and either sex. Studies were made under a Tesla BS-300 scanning electron microscope connected to an EDAX-149-10 X-ray detector and a BMG-38100 X-ray analyser using 15 kV accelerating voltage, 100 pA test-current and 20 s measuring time. Different bone substances (lamellae, Haversian canals, interstitial bone) showed similatr Ca: P ratios (p greater than 0.05). However, mean mol-ratio was found to decrease with age and this was still significant (p greater than 0.05) at 95% level. The equation of the regression line was: y = -0.0013x + 1.8275, where y represents Ca: P ratio x the age. There was a close correlation between the molar ratio of Ca and P which enables this method to be applied for the assessment of individual age in forensic medicine and paleoanthropology.

Age Determination by Skeleton↗
PubMed1987

[A new criminologic procedure: study of L-cystine-aminopeptidase activity for the detection of seminal stains].

L-Cystine-aminopeptidase (CAP) enzyme cleaves L-cystine-di-beta-naphthylamide substrate to beta-naphthylamine. The final product of this process is a violet azostain. CAP enzyme determination was developed for criminological procedures. CAP shows almost 100 times greater activity in human semen than in other body fluids. Samples taken at different time intervals (1 week, 1-3-6 months, 1 year, and 5-10 years) were investigated; they were dried on cloth and filter paper and then stored at room temperature for various time periods. The enzyme was also shown to be specific in the comparative studies performed with other human secretions (nasal discharge, saliva, vaginal secretion, feces, urine, breast milk) and fruit juices (raspberry, strawberry, apple, pear, plum, tomato, etc.).

Aminopeptidases↗
PubMed1985

Erythrocyte enzyme allotypes in the X-linked recessive disorders, Duchenne muscular dystrophy and haemophilia-A hemizygotes and heterozygotes.

The erythrocyte enzyme-systems acid phosphatase, phosphoglucomutase, glutamate pyruvate transaminase, adenosine desaminase, adenylate kinase, glyoxase, glucose-6-phosphate dehydrogenase and esterase-D-isoenzyme phenotypes were studied for their percentile distribution and were compared with their incidence in the diseases with X-linked recessive heredity, Duchenne muscular dystrophy (DMD) and haemophilia-A, in hemizygous male children and heterozygous mothers. Considering the frequency distribution of the above mentioned isoenzyme phenotypes of the enzyme-systems in DMD, the phenotypes proved to be homogeneous, only the X transmitted 6-phosphogluconate dehydrogenase (6-PGD) isoenzyme types were found to be genetic markers in DMD hemizygotes and heterozygotes. In these genotypes the 6-PGD A phenotype showed a decrease while the phenotypes 6-PGD AB and B were significantly increased. The adenylate kinase (AK) 2-1 isoenzyme phenotype was increased to 25% against the population frequency of 6.34%, while the AK 1-1 phenotype occurred in 75% against its population frequency of 93.59%, showing a significantly decreasing tendency in haemophilia-A hemizygotes and heterozygotes.

Acid Phosphatase↗
PubMed1984

A new method in criminology: use of ELISA to detect AFP on different materials with monoclonal anti-alpha-fetoprotein.

A new method has been introduced to distinguish normal adult serum stains from fetal or newborn serum and amniotic fluid stains with ELISA in cases of criminal abortion and infanticide. The method is based on the sensitive detection of alpha-fetoprotein (AFP) by a two-site enzyme immunoassay (EIA) following its elution with high efficiency from different materials (e.g., cotton, paper, synthetic fabric, or glass) by phosphate-buffered 0.5 M NaCl solution.

Adult↗
PubMed1982

[Population-genetic examination of the glyoxalase I (GLO) red-cell isoenzyme system in the inhabitants of Szeged and its environment (South-Hungary) (author's transl)].

The authors have examined the gene frequency and phenotype distribution of GLO isoenzyme system in the blood samples from 1,288 randomized, unrelated persons and from 151 mother-child pairs by horizontal starch-gel electrophoresis. The observed gene frequencies (GLO1 = 0.3990, GLO2 = 0.6009) and phenotype distributions (GLO 1 = 18.1%; GLO 2-1 = 43.79%; GLO 2 = 38.20%) were in good accordance with that of the Caucasian population. The authors did not find any difference from the genetic model of two codominant alleles at an autosomal locus. The theoretical exclusion rate in paternity cases based on the GLO gene frequencies is 18.23%.

Adult↗