[The glyoxalase I isoenzyme polymorphism test and its application in paternity suits].
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Biomedical subjects
Publications and source records attributed to F Kósa.
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The authors have examined 1,480 random and unrelated persons who belonged to South Hungarian (Szeged and its environment) population and 159 mother-child pairs by starch-gel electrophoresis to determine the distribution of EsD enzyme polymorphism. The distribution of phenotype was as follows: EsD 1-1 = 80.74%, EsD 2-1 = 11.97%, EsD 2-2 = 1.28%. The gene-frequency values were: EsD1 = 0.8973 and EsD2 = 0.1027. The observed values do not differ significantly from the mean values of the Central European populations. The results of the examinations on mother-child pairs confirmed the established formal genetic theory of the inheritance of EsD enzyme polymorphism.
To the patient of surgical department after the operation instead of 10 percent solution of sodium chloride 20 ml of petrol was injected intravenously. After that immediately tonoclonic spasms, loss of consciousness and in 3/4 hours death followed. The doctor giving the injection was sentenced to three month imprisonment with the arrest of judgement. The nurse, who had changed the solution in the bottle in question without changing the label on it, was sentenced to four month imprisonment.
A shot injury to the middle cerebral artery caused occlusion to the vessel by thrombosis and emboly of the missile. The projectil had been removed, but a thrombus formed in the a. cerebri media as a postoperative complication or by progression of a thrombosis in the internal carotid artery and after 19 days the patient died. A focal emollition of the left cerebral hemisphere was found at autopsy.
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Five cases of amnion fluid embolism are reported. In the first case the cause of the death was the obstruction of the lung-vessels. In the lung tissue calcium embolia could also been detected. In the second case embolization started--at unruptured amnionsac--with ecclampsia-like convulsions, later it was followed by coagulopathia. In the third case amnion fluid embolism was complicated by coagulopathia. In the fourth case in addition to amnion fluid embolism endometritis purulenta complicated by endotoxinaemia and coagulopathia were also present. In all four cases rupture of the uterus was revealed. In the fifth case amnion fluid embolism developed without the rupture of the uterus. At the autopsy of cases of maternal death the possibility of amnion fluid embolism should always be considered. Although macroscopic changes seen at amnion fluid embolism are not pathognomic, when clinical and pathological symptoms of haemorrhagic diathesis are present, there always arises the suspicion of amnion fluid embolism. Since lungs are relatively resistant to putrefaction amnion fluid embolism in optimal cases can be diagnosed histologically even in exhumated lung specimen. Reliable diagnosis of amnion fluid embolism in cases of sudden maternal death gives possibility to exclude medical negligence.
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