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Biomedical subjects

F Klein

Publications and source records attributed to F Klein.

At least 91 records · Page 5Linked to original sources
PubMed1981

Presence of immune complex-like material in sera of patients with paraproteinaemia.

Immunoglobulins of all classes as well as C3 are phagocytosed by normal human granulocytes from sera containing paraproteins. The material that was phagocytosed had the sedimentation properties of immune complexes. Cytostatic treatment did not seem to have a clearcut influence on the presence or absence of these complexes. There was little correlation with two other immune complex detecting tests. The Clq binding test was frequently found positive in paraproteinaemic sera but without apparent correlation to IgG phagocytosis. On the other hand the conglutinin binding test was rarely positive, although C3 was frequently phagocytosed.

Antigen-Antibody Complex↗
PubMed1981

[Potter syndrome].

Explore the source record for details and available documents.

Abnormalities, Multiple↗
PubMed1980

Serum IgM in primary biliary cirrhosis.

Serum IgM concentrations were measured in 25 patients with primary biliary cirrhosis (PBC) and 25 age- and sex-matched controls by the classical Mancini technique and by a modified method, which included reduction to 7 S monomers. Standards calibrated against the WHO standard, as well as a serum standard with an absolute value calibrated by immunological and non-immunological techniques, were used. All patients had an elevated IgM level; measurement of serum IgM is therefore a simple and sensitive screening test for patients with cholestasis. When measured with the standard calibrated against the WHO standard, the average IgM levels for PBC patients and controls agreed with results previously reported; the average IgM levels were much lower when a serum standard with an absolute IgM value was used; further standardization in needed. The differences in the ratio of the IgM measured by the classical method (pentameric IgM) to that measured by the alternative method (monomeric IgM) support the existence of different IgM subgroups or the in vivo presence of monomeric IgM in some patients with PBC.

Adult↗
PubMed1980

Lipid changes in the normal proximal and distal stumps of the rat sciatic nerve and during Wallerian degeneration.

The lipid composition of normal proximal and distal stumps of the rat sciatic nerve was studied. The highest lipid content was found in the proximal stump. A parallel decrease of lipid phosphorus, free cholesterol, and galactose contents were observed in both stumps until the 30th day of degeneration. 60 days after nerve section, the investigated parameters increased again in the proximal stump, but remaining, however below the normal values. During the same period, no such increase was found in the distal stumps. Phospholipids decreased in the proximal stump until 30 days after nerve section and increased thereafter. In the distal stumps, the phospholipids decreased sharply at 15 days after nerve section and their levels remained very low thereafter.

Animals↗
PubMed1980

Anti-immunoglobulins and heterophil agglutinins in experimental trypanosomiasis.

Rheumatoid factor (RF)-like substances and heterophil agglutinins (HA) were induced in rabbits by infection with a strain of Trypanosoma equiperdum. Infection with a T. gambiense strain produced HA, but no RF. RFs appeared usually before immunoglobulin G (IgG) levels started to increase. They disappeared spontaneously after 4 to 6 weeks. HA were of the IgM class, appeared within 1 to 2 weeks after infection, and usually remained at high levels afterwards. They could not be absorbed out with lyophilized whole trypanosomes. Therapy suppressed the formation of RF as well as of HA, but IgG complexes as well as antibodies against trypanosomal antigens remained present for considerable periods after the installment of therapy. It is concluded that RFs are not induced by IgG complexes. The results suggest that HA are probably not cross-reacting antibodies induced by trypanosomal antigens.

Agglutinins↗