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F L Ampil

Publications and source records attributed to F L Ampil.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Radiotherapy alone for extradural compression by spinal myeloma.

Between 1976 and 1992, 18 patients with a histologically proven diagnosis of plasma cell myeloma (PCM) were treated for palliation of spinal extradural compression (EC) by radiotherapy alone. Eighty-five percent of the evaluable symptomatic individuals obtained significant pain relief. Ambulatory ability was retained or regained in 11 (65%) patients. The overall median period of survival was 11 months. Extended median survival was noted in post-treatment ambulatory patients (compared with nonambulatory patients) and in individuals whose primary presentation of PCM was EC (versus individuals who developed EC during the course of the disease). These results suggest that radiotherapy alone may be used in the palliative management of patients with EC by PCM.

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PubMedDate not supplied

Timing of radiotherapy in asymptomatic patients with inoperable non-small cell lung cancer: a survival analysis and literature review.

PURPOSE: A retrospective study of survival relative to the timing of radiotherapy (RT) in asymptomatic patients with inoperable localized non-small cell lung cancer (ILNSCLC) was undertaken to assess whether early radiotherapy was more beneficial than deferred irradiation in these individuals. METHODS: Between 1981 and 1989, 58 asymptomatic patients with ILNSCLC received early (n = 41) or deferred (until symptoms developed; n = 17) RT. RESULTS: The cumulative survival rate at five years of patients treated early was 12% and that of patients irradiated later was 0% (p > 0.31). The observed difference may be attributed to the fact that more patients managed by deferred RT received lower prescribed radiation doses than individuals who were treated early (p < 0.001). CONCLUSION: We can only conclude that the chance of cure is compromised when asymptomatic patients with ILNSCLC are managed by a surveillance policy and an abbreviated course of delayed RT.

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PubMedDate not supplied

Glottic cancer with subglottic extension.

The outcomes of 27 patients with glottic cancer extending into the subglottis (GCSE) who were treated by surgery and radiation (n = 17) or radiation alone (n = 10) during a 13-year period were retrospectively reviewed. Since this study was nonrandomized and retrospective, the patient groups were not equally matched with regard to age (p > 0.05), gender (p > 0.30), or disease stage (p > 0.05). The locoregional failure rate was 18 +/- [95% CI] 20% in patients who received combined therapy and 40 +/- 31% in persons treated by radiation alone (p = 0.20); the corresponding survival rates at two years were 53 +/- 24% and 42 +/- 31% (p > 0.50). These findings suggest that GCSE may be better managed by a combination of surgery and radiotherapy than by the use of radiotherapy alone.

Adult↗
PubMedDate not supplied

Treatment in patients with glioblastoma multiforme and poor performance status: is it worthwhile?

It has not been ascertained that treatment of glioblastoma multiforme of the brain (GMB) favorably alters the prognosis in patients with poor pretreatment performance status (PPS). We report on 52 patients with GMB and PPS. The mean survival of 43 treated persons was 19 +/- 12 months (95% confidence interval) and of nine untreated individuals, 2 +/- 1 months (p > 0.50); the corresponding survival rates at 1 year were 39 +/- 16% and 0% (p > 0.05) and at 2 years, 15 +/- 12% and 0% (p > 0.40). We recommend active treatment of patients with GMB even when they present with poor functional status.

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