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Biomedical subjects

F Lechin

Publications and source records attributed to F Lechin.

At least 55 records · Page 3Linked to original sources
PubMed1982

On the use of clonidine and thioproperazine in a woman with Gilles de la Tourette's disease.

A 25-year-old woman with Gilles de la Tourette's disease was successfully treated with clonidine (an inhibitor of noradrenaline release). However, the drug was stopped because of side effects. Thioproperazine, a phenothiazine derivative which blocks subcortical dopaminergic receptors, suppressed Gilles de la Tourette's symptoms totally. The patient has tolerated the drug well for over a year since its introduction. The pharmacomanometric investigation performed in this patient showed hyperactivity of her noradrenergic system.

Adult↗
PubMed1981

Intestinal pharmacomanometry and glucose tolerance: two kinds of dopaminergic mechanisms in the human.

In this article are presented cumulative data dealing with the existence of more than one dopamine-receptor in mammals. In addition, evidence referring to the existence of two antagonistic dopamine-functional expressions in the human, is also presented. This fact along with the disclosure of new dopaminergic agonistic and antagonistic drugs will surely aid in the management of diseases in which these drugs have proven to be good therapeutic tools.

Animals↗
PubMed1981

Intestinal pharmacomanometry and glucose tolerance: evidence for two antagonistic dopaminergic mechanisms in the human.

In this article cumulative data are presented dealing with the existence of more than one dopamine receptor in mammals. In addition, evidence is presented for the existence of two antagonistic dopamine-functional expressions in the human. This fact, along with the disclosure of new dopaminergic agonistic and antagonistic drugs, should prove useful in the management of diseases in which these drugs have proven to be good therapeutic tools.

Animals↗
PubMed1980

Distal colon motility in schizophrenic patients.

Although the dopaminergic blocking agents (DBA) haloperidol and sulpiride strongly inhibit distal colon motility in most nonpsychotic subjects (83 per cent), this effect was registered in only 10 per cent of the 30 schizophrenic patients investigated in the present study. In these cases, only sulpiride (an "atypical" DBA) displayed distal colon motility inhibition in schizophrenic subjects. When haloperidol (a "classical" DBA) produced any modification (in 23.3 per cent), this was rather in the nature of an increase in motility. All these cases showed low or absent distal colon motility during preinjection periods. the fact that three different types of antinoradrenergic drugs (dihydroergotamine, phentolamine, and clonidine), but not DBA, inhibited distal colon motility in 90 per cent of the schizophrenic subjects suggests the existence of an overactivity of the noradrenergic system at this peripheral level.

Adolescent↗
PubMed1979

Effects of captivity on glucose tolerance in dogs.

Captivity decreased tolerance to glucose and increased blood serotonin levels in 6 normal dogs investigated. Return to freedom brought normalization in the glucose tolerance test and reverted blood serotonin to control levels.

Animals↗
PubMed1979

Effects of dopaminergic blocking agents on distal colon motility.

Four different dopaminergic blocking agents were able to modify the motility of the distal colon: haloperidol, sulpiride, pimozide, and thioridazine. Haloperidol and sulpiride induced different and frequently antagonistic responses; however, the effects induced by these drugs changed depending on the preexisting pattern of motility. Intestinal tone and sigmoidal or rectal phasic activity predominance are the main factors that influence responses. Biperiden, a centrally acting anticholinergic drug, and dihydroergotamine, an antinoradrenergic drug, annulled the rebound of motility induced by sulpiride in high intestinal-tone and low intestinal-tone subjects, respectively. Our results suggest that the dopaminergic system plays a role in the distal colon motility in humans.

Adolescent↗
PubMed1979

Effects of diphenylhydantoin (DPH) on distal colon motility.

Diphenylhydantoin (DPH) induced changes in distal colon motility in the 37 subjects investigated. In subjects with sigmoidal hyperactivity plus rectal hypoactivity, DPH suppressed or reduced sigmoidal phasic activity. In subjects showing no sigmoidal activity predominance, DPH induced increases of sigmoidal and/or rectal motility. Sulpiride (an "atypical" dopaminergic blocking agent) antagonized DPH-induced changes. Our results strongly suggest that DPH-induced distal motility changes are mediated by the dopaminergic and noradrenergic systems.

Adult↗
PubMed1978

Adrenergic influences on the gallbladder emptying.

Dihydroergotamine (dhe) (or phentolamine), an alpha-adrenergic blocking agent, induced important changes on the CCK-stimulated gallbladder emptying of 70 volunteer subjects. Two cholecystograms were performed with 10-day intervals in each subject. The first cholecystogram showed gallbladder emptying provoked by a test meal (35 subjects or by 0.5 U. CCK Kg. injected intravenously (35 subjects). During the second cholecystogram 1 mg. of DHE was injected intramuscularly 45 minutes befor the cholecystokinetic stimulus. The drug counteracted the gallbladder emptying induced by both endogenous and exogenous CCK. The effect was more pronounced when DHE was administered prior to the test meal stimulus than before CCK administration. This difference could be explained by a delayed gastric emptying induced by the alpha-adrenergic blockade. Our results suggest that the lack of gallbladder emptying could be due to the relaxation of this organ, in addition to a duodenal spasticity induced by DHE (or phentolamine).

Adolescent↗
PubMed1977

The "spastic colon" syndrome: therapeutic and pathophysiologic considerations.

Low doses of d-amphetamine plus propranolol rapidly improved the abdominal pain in 165 "spastic colon" patients. Concomitantly, these drugs reduced the sigmoidal hypertonicity and the rectal inhibition found in the manometric studies performed in some of those patients. The sigmoidal tone and phasic activity were also decreased by anticholinergic drugs. These results suggest that a cholinergic-serotonergic hyperactivity of the myenteric plexus may be responsible for the "spastic colon" syndrome.

Adolescent↗