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Biomedical subjects

F Lechin

Publications and source records attributed to F Lechin.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Antidiarrheal effects of dihydroergotamine.

Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone. On the other hand, anticholinergic drugs and/or emotional stimuli accentuate the rectal hyperactivity of diarrheal patients. Both features could be due to an unbalanced neurologic control of the gastrointestinal tract with dominance of the alpha-adrenergic over the cholinergic activity. Diphenoxylate (DPO) suppressed the diarrhea in two patients not improved by DHE. Furthermore, DPO reinforced the therapeutic success of DHE in 11 lactose intolerance diarrheal patients, suggesting that the two drugs exert their effects by means of different mechanisms.

Adolescent↗
PubMedDate not supplied

Pharmacomanometric studies of colonic motility as a guide to the chemotherapy of schizophrenia.

Distal colon motility studies performed in 41 psychotic subjects demonstrated that 32 of them had hyperactivity of the noradrenergic system at this peripheral level, while the remaining nine cases showed hyperactivity of the dopaminergic system. The noradrenergic-hyperactive patients fulfilled the Research Diagnostic Criteria of schizophrenia, whereas the dopaminergic-hyperactive patients were diagnosed as having schizoaffective disorders. Noradrenergic-hyperactive subjects were successfully treated with clonidine, a drug which inhibits release of noradrenaline, while dopaminergic-hyperactive subjects were successfully treated with clonazepam, a drug which inhibits release of dopamine. The addition of sulpiride (a postsynaptic dopaminergic blocking agent) and of phentolamine (a postsynaptic noradrenergic blocking agent) to clonidine and clonazepam, respectively, induced further significant improvements in both types of psychotic patients.

Adult↗
PubMedDate not supplied

Opposite effects on human distal colon motility of two postulated alpha 2-antagonists (mianserin and chlorprothixene) and one alpha 2-agonist (clonidine).

The effects of two postulated alpha 2-antagonists (mianserin and chlorprothixene) and an accepted alpha 2-agonist (clonidine) on the distal colon motility in five healthy subjects were investigated. Opposite effects were induced by these two kinds of drugs. Distinct and characteristic motility responses were obtained from subjects with low distal colon tone and subjects with high distal colon tone. In addition, different and typical behavior responses paralleled motility changes in the two types of subjects. These results suggest that, at the doses employed in this study, both mianserin and chlorprothixene behave as alpha 2-antagonists when tested on human distal colon motility against a known alpha 2-agonist such as clonidine.

Adult↗