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Biomedical subjects

F Lescure

Publications and source records attributed to F Lescure.

26 records · Page 2Linked to original sources
PubMed1984

Effect of lysine-acetylsalicylate and phenylbutazone premedication on the protein content of secondary aqueous humour in the dog.

Inhibitory effects of the anti-inflammatory agents lysine-acetylsalicylate (LAS) and phenylbutazone (PBZ) on the breakdown of the blood-aqueous barrier by paracentesis were studied in canine eyes using protein determination of ocular fluid. In the untreated eyes the aqueous protein value was raised from 0.29 +/- 0.17 (mean +/- SD) g litre-1 at the initial paracentesis to 14.47 +/- 4.10 g litre-1 at the second paracentesis. Pretreatment with LAS or PBZ had no significant effect on the protein concentration of the primary aqueous humour. However the secondary aqueous protein concentration was only 10.05 +/- 7.00 g litre-1 with LAS and 5.80 +/- 3.83 g litre-1 with PBZ. With both drugs the maximum inhibitory effect was observed on the gammaglobulins and albumin. These results suggest that prostaglandins may be involved in the response of the canine eye to paracentesis and that premedication with LAS or PBZ may be of value in reducing postoperative ocular inflammation.

Analgesics↗
PubMedDate not supplied

Physico-chemical characterization, preparation and performance of poly (methylidene malonate 2.1.2) nanoparticles.

The present investigation confirms that initially implemented procedure to produce poly(methylidene malonate 2.1.2) (PMM 2.1.2) nanoparticles (Lescure et al. Pharm Res 1994;11:1270-77) lead to products mostly containing plasticizing oligomers which strongly lowered glass-transition temperature (Tg), dramatically reduced nanoparticle consistency and rendered them too sensitive to solubilization when diluted in an aqueous medium. From MALDI-TOF spectroscopy analysis, performed on intact colloids, emerged some structural information about these oligomeric species which could result from an intramolecular cyclization mechanism occurring soon in the course of the polymerization process. Thus, with the objective of overcoming these drawbacks, this contribution deals with the variations of manufacturing specifications such as pH and magnetic stirring speed to try and modulate molecular weight (MW) of nanoparticle constituents and reduce oligomer concentration. Although the analyses performed on these new nanoparticles were rather encouraging, the colloid formation yield became so low that it required the development of other methodologies, excluding a previous emulsion step, and allowing a controlled production of PMM 2.1.2-made nanoparticles having better physico-chemical characteristics while keeping good pharmaceutical capabilities.

Biocompatible Materials↗
PubMedDate not supplied

[Diagnosis of hereditary retinopathies in the dog. The value of fluorescein angiography and electrophysiology].

The diagnosis of the hereditary ocular diseases is a very actual question. These affections are divided in two parts: congenital diseases, abiotrophies. The dog that the practitioner has to examine will be: sometimes a puppy, sometimes an adult. In the puppy the diagnosis will be easy in the case of a congenital disease, it will be more difficult in the case of an abiotrophy. In the adult the practitioner will be hesitating between an hereditary or an acquired disease. In all the cases, the diagnosis of the posterior segment diseases and of the amaurosis will be made easier by the data of the fluoresceinic angiography and the electrophysiology (ERG and VEP).

Animals↗