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Biomedical subjects

F M Moore

Publications and source records attributed to F M Moore.

At least 37 records · Page 2Linked to original sources
PubMed1991

Adherent gram-positive cocci on the intestinal villi of two dogs with gastrointestinal disease.

Two dogs were examined for clinical signs of chronic gastrointestinal disease. Duodenal mucosal biopsy specimens, obtained endoscopically, revealed histologic lesions of adherent gram-positive cocci on the villus epithelium of both dogs. The positive gram stain and morphologic features of the adherent cocci were suggestive of Streptococcus organisms. Indirect tests for intestinal bacterial overgrowth were not diagnostic, suggesting that the adherent cocci were a primary lesion. Rapid clinical response following dietary manipulation and the initiation of medical management was observed in both dogs. The dogs of this report draw similarities to Streptococcus durans infection previously reported in pigs, foals, and a single pup. The pathogenesis of enteric disease associated with adherent gram-positive cocci in dogs remains ill-defined.

Animals↗
PubMed1991

Distinctive unclassified mesenchymal tumor of the digit of dogs.

Four examples of a mesenchymal tumor of undetermined histogenesis occurred in three mixed-breed dogs and one Yorkshire terrier. All tumors occurred as solitary, soft to firm, solid, tan, and ulcerated masses in the digits of dogs aged 11 to 15 years. The compact cellular tumor had cells with anisokaryotic round, oval, or irregular nuclei, some of which were multinucleated. The neoplastic cells appeared to arise in the tissue near the third phalanx in the area of dense collagenous trabeculae located proximal to the fat pad and sweat glands. The unclassifiable cells had some features of histiocytes by transmission electron microscopy, but failed to stain for lysozyme and alpha-1-antichymotrypsin, markers for monocyte-macrophage derived cells. Immunohistochemically, the cells stained for vimentin but not for cytokeratins, desmin, S-100 protein, epithelial membrane antigen, alpha-lactalbumin, lysozyme, alpha-1-antichymotrypsin, alpha-lactalbumin, casein, and heavy and light chain immunoglobulins. The combined findings of light and transmission electron microscopy and immunohistochemistry exclude tumor histogenesis from an epithelial cell, melanocyte, mast cell, plasma cell, Schwann cells, and Merkel cell.

Animals↗
PubMed1991

Detection of cannabinoids in urine: a cost-effective low risk immunoassay procedure.

Using Syva EMIT reagents and a Cobas Bio centrifugal analyser we have developed a cost-effective assay for the detection of cannabinoids in urine. With this method, up to 1500 samples can be assayed with a single 100 test kit while maintaining acceptable precision. A mean CV of 6.1% was obtained for the concentration range 80-130 micrograms/l. The method is suitable for high-risk urines since heart treatment may be performed prior to analysis. There was no significant change in the measured concentration of cannabinoids in urine samples on storage in plastic containers, refrigerated or frozen, for up to seven weeks.

Cannabinoids↗
PubMed1990

Chordoma in a cat.

A chordoma within the deep musculature adjacent to C3 and C4 was excised from a 14-year-old castrated domestic cat. Metastatic chordoma developed in a prescapular lymph node 10 months later. At necropsy 11 months after complete excision of the primary tumor, metastases were found in both retropharyngeal lymph nodes.

Animals↗
PubMed1990

What about the quality of care.

As the numbers of homemaker-home health aide services grow, it is clear that there is an urgent need to improve and maintain the quality of paraprofessional services. Because homemaker-home health aide services affect the public good, it is important that the federal government be involved in developing and enforcing quality assurance standards. The establishment of national standards must become a priority for the government as well as for national, state, and local associations.

Home Care Services↗
PubMed1990

Detection of benzoylecgonine (cocaine metabolite) in urine: a cost-effective low risk immunoassay procedure.

Using Syva EMIT reagents and a Cobas-Bio centrifugal analyser we have developed a cost-effective assay for the detection in urine of benzoylecgonine, one of the main metabolites of cocaine. With this method up to 2470 samples can be assayed with a single 100-test EMIT Kit while maintaining acceptable precision. A mean CV of 7.0% was obtained for the concentration range 240-620 micrograms/l. Comparison of the method with the Abbott TDx system showed good correlation. The Cobas-Bio method is suitable for high-risk urines since heat treatment may be performed prior to analysis.

Cocaine↗
PubMed1989

Argyrophilic, intracellular bacteria in some cats with idiopathic peripheral lymphadenopathy.

Lymph node biopsy specimens from several previously reported cases of unusual feline peripheral lymphadenopathies were re-examined by a modified Dieterlé silver-impregnation staining technique. In a proportion of these specimens, the Dieterlé stain revealed tiny pleomorphic, intensely argyrophilic coccobacilli. These organisms were predominantly located within macrophages. The infected cells were focally distributed, particularly in the interfollicular regions of the nodes. They were inconspicuous in sections stained by other, more conventional staining methods. It is possible that these coccobacilli represent yet another, previously unidentified, cause of chronic lymph node hyperplasia in the cat.

Animals↗
PubMed1989

Cost-effective assays for use in monitoring carbamazepine, phenobarbital, and phenytoin in serum.

Using Syva "EMIT" reagents and the Cobas Bio centrifugal analyzer, we have developed cost-effective assays for therapeutic drug monitoring of carbamazepine, phenobarbital, and phenytoin. With these optimized methods one can assay up to 2470 samples with a single 100-test EMIT kit with good precision and accuracy. Between-batch CVs, based on results of repeat analysis of routine patients' samples, were 4.6%, 7.0%, and 5.3%, respectively. Results correlated well with those by methods previously used [gas chromatography and fluorescence polarization (Abbott TDx)], but there was a negative bias (-10.9%) of our method for phenobarbital results in patients' samples, as compared with those obtained with the TDx.

Carbamazepine↗
PubMed1989

Detection of opiates in urine: a cost-effective low risk immunoassay procedure.

A cost-effective immunoassay for the detection of opiates in urine has been developed using commercial reagents on a centrifugal analyser. Using this method it is possible to assay up to 2470 samples with a 100 test kit while maintaining good precision. A mean CV of 4.2% was obtained for the concentration range 123-573 micrograms/l. The assay is suitable for high-risk urines since rigorous heat treatment may be performed prior to analysis.

Autoanalysis↗
PubMed1989

Feline muscular dystrophy with dystrophin deficiency.

This is the first description of a dystrophin-deficient muscular dystrophy in domestic cats. The disorder appears to be of X-linked inheritance because it affected both males of a litter of four kittens. Immunoblotting and immunofluorescent detection of dystrophin showed dystrophin present in control cat muscle but no detectable dystrophin in either affected cat. The feline muscular dystrophy was progressive and histopathologically resembled human Duchenne/Becker muscular dystrophy except for the lack of fat infiltration and the presence of prominent hypertrophy of both muscle fibers and muscles groups in the feline disorder.

Animals↗
PubMed1988

Hypercalcemia associated with rodenticide poisoning in three cats.

Hypercalcemia (12.0 to 18.3 mg/dl) was detected in 3 cats that had eaten a rodenticide that contained cholecalciferol. Clinical signs included lethargy, anorexia, vomiting, and polydipsia. Treatment with furosemide and fluids administered IV resulted in normalization of the serum calcium concentration and in remission of the clinical signs in 2 cats. One cat with a serum calcium concentration of 18.3 mg/dl did not have clinical signs, was not treated, and was reportedly normal 9 months after initial examination. We attributed the uniformly favorable outcome of exposure to the rodenticide in these cats to the small quantity of the toxin ingested.

Animals↗
PubMed1988

Polyarteritis nodosa and rheumatic heart disease in a dog.

A 12-year-old spayed Corgi-type dog developed an acute febrile illness about 2 weeks after excision of a subcutaneous arteriovenous fistula. The dog was moribund after 1 week of illness and was euthanatized. Necropsy disclosed uncommon lesions comparable to those of polyarteritis nodosa and rheumatic heart disease of human beings. The pathogenesis of the arterial and cardiac lesions was not established, but was consistent with that of an immune-mediated mechanism.

Animals↗
PubMed1988

Idiopathic cutaneous and renal glomerular vasculopathy of greyhounds.

An idiopathic disease involving skin and occasionally kidneys was seen in kenneled and racing greyhounds. Hemorrhages, fibrinoid arteritis, thrombosis, and infarction with deep, slowly healing ulcers characterized the skin lesions. Peracute renal glomerular necrosis, particularly involving afferent arterioles with intravascular coagulation in glomerular capillaries were the distinctive findings in affected kidneys. A complex pathogenesis of this disorder was suspected in which genetic predisposition plays a prominent role.

Animals↗
PubMed1988

Noncortical origins of the spinal motor evoked potential in rats.

Motor evoked potentials (MEPs) were recorded from the spinal cord, sciatic nerve, or both during transcortical electrical stimulation in the rat. Four peaks could be consistently identified in the spinal MEP. The latency and amplitude of the peaks varied differentially with intensity and polarity of stimulation. Conduction velocity for Peak 1 of the MEP was 43 m/sec. Bilateral sciatic nerve MEPs were present after unilateral cortical stimulation. The spinal MEP was elicited by stimulation of areas outside the motor cortex, and the response persisted during subcortical stimulation and after motor cortex ablation. We present evidence suggesting that components of the spinal MEP in rats arise from pathways outside the motor cortex.

Action Potentials↗