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Biomedical subjects

F Mari

Publications and source records attributed to F Mari.

At least 55 records · Page 3Linked to original sources
PubMed1983

Analgesic interaction between nitrous oxide and delta-9-tetrahydrocannabinol in the rat.

The analgesic activities of a 75:25% nitrous oxide-oxygen mixture administered for 15 min, of delta-9-tetrahydrocannabinol (THC) 10 mg kg-1 i.p., and of a combination of both, were evaluated in the rat by tail-flick and hot-plate tests. The nitrous oxide-oxygen mixture produced a significant increase in the pain threshold. The analgesic activity of THC was similar in extent but of longer duration than that of nitrous oxide. The cannabinoid also induced some locomotor and behavioural modifications. When both THC and the nitrous oxide-oxygen mixture were administered, a significant potentiation of the analgesic response was produced, without modification of the locomotor and behavioural responses that were induced by THC alone. Such mixtures may prove of value in the control of chronic pain in man.

Analgesia↗
PubMed1980

Observations on cannabinoid content in Cannabis sativa L. grown in Tuscany, Italy.

The paper summarizes the analytical results on 114 Cannabis sativa L. samples seized in Tuscany. The percentage of delta 9-tetrahydrocannabinol content in adult plants and the phenotype ratio of young plants were determined to differentiate fibre-type from drug-type cannabis plants. The analysis revealed that 71.9 per cent of the total sample were cannabis plants of a drug type.

Cannabinoids↗
PubMed1980

Anti-inflammatory agents: determination of ibuproxam and its metabolite humans. Correlation between bioavailability, tolerance and chemico-physical characteristics.

A study on absorption and elimination in the urine of 2-(4-isobutylphenyl)-propiohydroxamic acid (ibuproxam, Ibudros) (400 mg film tablets) after administration to healthy volunteers is reported. In the plasma, only a minimum concentration of ibuproxam as such could be found: instead its chief metabolite ibuprofen mainly present, with top peaks at 45 min. The maximum ibuprofen concentration in the plasma--when obtained through metabolization of ibuproxam--is significantly higher than after administration of an equal dose of ibuprofen. This phenomenon is related to the chemico-physical characteristics of the two compounds.

Adult↗
PubMedDate not supplied

Combustion products from various kinds of fibers: toxicological hazards from smoke exposure.

The smoke exposure hazards during combustion of carbon and nitrogen-containing fibers were evaluated in guinea pigs intoxicated by gradual exposure to HCN and CO neo-formed from foam rubber, wool and PAN (Polyacrylonitrile). The most prominent result of our study was that the neo-formation of HCN from 1 g of PAN was 1500 ppm, much higher than from foam rubber and wool because of the presence of many -CN groups in the polymer chemical structure. This concentration of HCN is estimated to be lethal. Extrapolating this data, a lethal concentration of HCN could be obtained by burning 2 kg of PAN in an average sized living room. The above-mentioned 1 g of PAN was burned in a 15.6-liter combustion chamber.

Acrylic Resins↗
PubMedDate not supplied

Comparison of lidocaine by fluorescence polarization immunoassay, enzyme immunoassay, and high resolution gas chromatography.

Lidocaine levels in plasma for therapeutic monitoring purposes were compared by using fluorescence polarization immunoassay (Abbott TDx), enzyme immunoassay (EMIT-Cad), and a high-resolution gas chromatography (HRGC). The two immunoassay methods on 29 clinical samples gave excellent correlation (r = 0.998 and 0.999 for TDx and EMIT, respectively), when compared to the HRGC method.

Chromatography, Gas↗
PubMedDate not supplied

Are behaviour and motor performances of rheumatoid arthritis patients influenced by subclinical cognitive impairments? A clinical and neuroimaging study.

OBJECTIVE: To determine whether some behavioural manifestations and poor motor performances in patients affected by rheumatoid arthritis (RA) are due to subclinical cognitive defects. METHODS: We performed a psychometric assessment of 30 patients affected by RA exploring several cognitive domains such as memory, visual-spatial integration, motor planning, mental flexibility, relating performances with morphological and functional neuroimaging (MRI and SPECT). We also related the cognitive data with the Ritchie and Lee indexes and other clinical parameters. RESULTS: We found an impairment in visual-spatial tasks in 71% of patients with a high correlation to activity and disease severity as expressed by the Ritchie and Lee indexes (p < 0.005; p < 0.01). Furthermore, we detected in 38% of patients some difficulties in mental flexibility related to the Lee Index (p < 0.05). These poor performances are related to hypoperfusion of the frontal and parietal lobes as detected by brain SPECT; this finding is more evident in patients with brain white matter alterations on MRI. CONCLUSIONS: Our data allow us to hypothesize that manual dexterity could be due to a disconnection between subcortical white matter and parietal-frontal lobes because of microangiopathy; furthermore, a chronic reduction in sensorial stimuli by impaired joints could lead to produce an alteration in motor planning cognitive processes.

Adult↗
PubMedDate not supplied

[Clinical and genetic features of the Alport 'syndromes'].

Alport syndrome (ATS) is a clinically and genetically heterogeneous progressive nephropathy often associated with deafness and/or ocular lesions. The histological aspect is characterized by thinning, thickening and splitting of the glomerular basement membrane (GBM). Alport syndrome is caused by mutations in COL4A3 gene (type IV collagen, alfa-3 chain), or COL4A4 gene (type IV collagen, alfa-4 chain) or COL4A5 gene (type IV collagen, alfa-5 chain) genes. Alport syndrome accounts for 1-2% of renal failure cases in Europe, and for 2-3% of transplanted patients in United States. This review focuses on the three types of Alport syndrome which differ in the clinical progression and in the mode of inheritance. The common X-linked form is caused by mutations in the COL4A5 gene and it accounts for 85% of cases. The autosomal dominant and the autosomal recessive forms are caused by mutations in either COL4A3 or COL4A4 genes. The autosomal recessive form which is responsible for the 10-15% of Alport cases, has been known since several years. On the contrary, the autosomal dominant form has only recently been identified in some families. Furthermore, this review will focus on the difficulties encountered during the genetic counselling related to the differential diagnosis between Alport syndrome and Thin Basement Membrane Disease (TBMD). We will report direct experiences of our group showing the difficulties to give an exact prognosis and a correct recurrence risk to the family.

Adolescent↗