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Biomedical subjects

F Matzkies

Publications and source records attributed to F Matzkies.

At least 91 records · Page 5Linked to original sources
PubMed1976

[Serum cholesterol concentrations in various basic diseases. Studies in 2466 hospital patients].

In 2466 in-patients the blood cholesterol concentration was measured. Also age, height, weight, excretory liver function, glucose tolerance, the concentration of total lipids, uric acid and the clinical diagnosis were correlated with the cholesterol levels. Higher cholesterol levels were found in elderly patients and in patients with impairment of liver function, glucose tolerance and with overweight. With increasing hight cholesterol decreases. Patients with disorders of gallbladder and liver had significantly higher cholesterol levels compared with patients with hematological disorders, malignancies and pulmonary affections.

Adult↗
PubMed1976

[Treatment of hyperuricaemia with a combination of allopurinol and benzbromaron (author's transl)].

Three patients with gout and seven with hyperuricaemia, previously untreated, took a single dose of 100 mg allopurinol and 20 mg benzbromaron (as a combined preparation) each morning. There occurred a highly significant decrease in serum uric acid concentration from 430.7 mumol/l (72.4 mg/l) to 268.6 mumol/l (45.2 mg/l), without any significant increase in urinary excretion of uric acid.

Allopurinol↗
PubMed1976

[Fasting values of carbohydrate--and lipid metabolism in healthy subjects and in patients with diabetes mellitus].

In 106 healthy adults and 34 in-patients with diabetes mellitus the venous blood concentration of lactate, pyruvate, hydroxybutyrate and acetacetate was measured. In healthy men we found a lactate concentration of 7.7 mg/100 ml (7.11-8.15), a pyruvate level of 0.37 (0.34-0.44) mg/100 ml, a level of acetoacetate of 0.41 mg/100 ml(0.38-0.47) and a level of hydroxybutyrate of 0.47 mg/100 ml(0.29-0.70).

Adolescent↗
PubMed1976

[Serum uric acid and uric acid elimination after benzbromarone therapy in patients with gout and hyperuricemia].

During treatment with benzbromaron in a dose of 100 mg/day a significant fall of uric acid was shown beginning on the second day. On the forth day in the evening or the fifth day in the morning a steady state for the uric acid level is reached. The morning value was 2,9 mg/100 ml, the evening value 2,6 mg/100 ml. During treatment, even when serum uric acid levels are decreased, an augmented renal uric acid elimination excists but a hyperuraturia was not found.

Benzbromarone↗
PubMed1976

[Metabolic effects of parenteral administration of a combined carbohydrate solution (glucose, fructose, xylitol 2:2:1) (author's transl)].

A combined carbohydrate in fusate (glucose, fructose, and xylitol in the ratio of 2:2:1) was administered to eight healthy adults at the rate of 0.5 g.kg-1.h-1 for 12 hours. The solution also contained 80 mmol sodium, 30 mmol potassium, 2.5 mmol magnesium, 2.8 mmol phosphate and 110 mmol chloride per litre. Glucose and fructose were almost completely metabolised. The percentage loss of xylitol was very low (8.9% of the administered dose). There was a slight insulin incretion and moderate rise in lactate concentration. No disorder of fat and uric acid metabolism and acid-base equilibrium was observed. Nor was there intravascular volume dilution, as measured by protein, albumin and haemoglobin concentration and haematocrit. There was a significant fall in phosphate concentration due to increased phosphate utilisation. Calcium concentration was also significantly decreased. Excretion of sodium was 10 mmol/h of potassium 4 mmol/h, phosphate 0.02 mmol/h and of magnesium 0.27 mmol/h. Sodium balance was positive in six patients, potassium and phosphate balance in five, magnesium and waterbalance in eight. There was no change in transaminases and lactate dehydrogenase. A typical sign of carbohydrate infusion was the slight rise in bilirubin concentration by 6.84 mumol/l. The tested carbohydrate combination can, at the stated rate of administration, cover the entire daily energy needs of an adult.

Blood Proteins↗
PubMed1976

[Electrolyte metabolism in obese subjects with various forms of therapy].

In 30 obese subjects three different methods for weight, reduction were applicated over a period of 14 days. One group (n=10) was treated with total starvation, the other group (n=10) with total starvation and 80 mval potassium in addition and the third group (n=10) with a 700 cal. diet. In total starvation the balance of sodium, potassium and phosphate amounted to -9 mval/d, -34,9/d and -8,8 mval/d respectively. Whereas calcium showed a positive balance of 4,4 mval/d. During addition of 80 mval potassium sodium excretion increased whereas potassium excretion was diminished resulting in a potassium balance less negative. During treatment with the 700 calorie diet the highest negative sodium and a high positive potassium balance were observed,

Calcium↗
PubMed1976

[Effect of maltose, following long-term intravenous infusion, on the metabolism].

6 healthy subjects received a 20% electrolyte containing maltose solution over a period of 6 hours. The concentration of maltose rose up to 109 (76-215 mg/100 ml). During the infusion period 3,7 (1,9-7,7) g maltose were excreted. The concentration of glucose and insulin was not altered, although the renal glucose loss was 20,2 (7,5-38,7) g. In the same period 49,8 +/- 13,2 mval potassium and 135,4 +/- 35 mval sodium were eliminated. Maltose induced an osmotic diuresis which was not caused by hyperglycemia. Such a type of osmotic substance has not been described before.

Adult↗
PubMed1976

[The effect of cytostatic therapy with vincristin sulphate on disaccarchidases of rat intestinal mucosa (author's transl)].

This report shows that appropriate doses of vincristin sulphate may decrease disaccharidase activities of intestinal mucosa. With the higher doses of the cytostatic drug, the drastic drop of enzyme activities is associated with morphological alterations of the mucosa; disacchardiase activities remain depressed at least for a couple of days even after full morphological restoration of the mucosa. Studies in man should reveal whether similar intestinal lesions occur due to therapeutic doses of vincristin sulphate.

Animals↗
PubMed1976

[Disaccharidases of the small-intestinal mucosa of the rat under therapy with ifosfamide (author's transl)].

In rats, treatment with 3-(2-chloroethyl)-2-(2-chloroethyl-amino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ifosfamide; Asta Z 4942) results in a decrease of intestinal disaccharidase activities concomitant with morphological alterations of the mucosa. Even after morphological restoration of the tissue, enzyme activities remain reduced for a couple of days. Examinations of patients treated with ifosfamide will show whether there are comparable effects also in man which may lead to malabsorption of disaccharidases.

Animals↗
PubMed1976

[Disaccharidases of the intestinal mucosa of the rat after cytostatic combined therapy with vincristin sulphate and ifosfamide (author's transl)].

Vincristin sulphate or 3-(2-chloroethyl)-2-(2-chloroethyl-amino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ifosfamide)--given alone--may reduce intestinal disaccharidase activities in the rat. However, combined administration of both the drugs, as used as a therapeutic means, results in a much more drastic decrease in enzyme activities. Consequently, also in man maldigestion of disaccharides might occur due to that polychemotherapy.

Animals↗
PubMed1975

[Effects of water with a low mineral content on serum electrolytes and blood pressure].

The effects of low-mineral content water (Adelholzener Primus-Quelle) in 62 patients were studied of which 14 were hypertonic. Changes of blood sodium, potassium, chloride and bicarbonate were not observed in either group. In the hypertonic patients, blood pressure decreased from a mean systolic value of 168 to 140 mmHg and mean distolic pressure from 105 to 88 mmHg. Observations to date suggest the following indications for a low-mineral content water diet: 1. hypertension, 2. renal insufficiency in stages of compensated and decompensated retention, especially in cases with high serum potassium levels, 3. in the initial therapy of diabetes, gout and obesity; patients with a high water demand should be treated with low-mineral content water until the optimal intake of electrolytes is established.

Blood Pressure↗
PubMed1975

Disaccharidases in rat small intestinal mucosa following cytostatic treatment with adriamycin.

Our studies have shown that appropriate doses of adriamycin can reduce the activities of the intestinal disaccharidases in the rat. At higher doses, in addition to morphological changes in the intestinal mucosa, a considerable fall in disaccharidase activities also occurs. This functional impairment can be seen for a period of several days after the morphological restitution of the mucosa. Appropriate studies of the small intestinal mucosa in man will have to be undertaken to show whether similar impairment occurs at therapeutic doses.

Animals↗
PubMed1975

[Ketone bodies in the blood during sorbitol infusion].

The concentration of hydroxybutyrate and pyruvate during infusion of sorbitol was significantly depressed in 12 healthy subjects. The dosage ranged between 0.25 and 0.50 g/kg BW/h. Considering the blood parameter the hunger ketosis was depressed by the infusion rate of 0.25 g/kg/h. Cholesterol concentration, too, was significantly lowered by sorbitol.

Acetoacetates↗
PubMed1975

[Diurnal variation of glucose tolerance and insulin secretion in man (author's transl)].

The present investigation was designed to determine whether the circadian rhythm of glucose utilization is based on a quantitatively different release of insulin and/or on changing secretory dynamics of the hormone. 22 healthy men received three oral glucose tolerance tests in the morning, afternoon and evening of the same day. The blood sugar levels in the afternoon and evening tests were significantly higher than those found in the morning tests. Also the plasma insulin response was higher in the afternoon than in the evening, but it showed a delayed rise and late peak response. In the evening the normal subjects responded as mild diabetics.

Adolescent↗
PubMed1975

[Serum lipoproteids and ketone bodies after constant infusion of sorbitol i.v. (author's transl)].

20 patients of a metabolic ward received a six-hour infusion of sorbitol at a dosis of 0.125 g/kg/h(n equal to 10) and 0.25 g/kg/h(n equal to 10) body weight. Cholesterol levels showed a significant fall in both groups (p smaller than 0.05) and triglycerides rose significantly (p smaller than 0.05). The concentrations of acetoacetate and beta-hydroxybutyrate were lowered irrespective of the dosis. The cholesterol-reducing effect can be explained by the antiketogenic action, whereas the increase in triglycerides possibly could be the result of raised alpha-glycerophosphate.

Acetoacetates↗