PubMed Health⌕ Search

Biomedical subjects

F Matzkies

Publications and source records attributed to F Matzkies.

At least 109 records · Page 6Linked to original sources
PubMed1975

[Effects of water with a low mineral content on serum electrolytes and blood pressure].

The effects of low-mineral content water (Adelholzener Primus-Quelle) in 62 patients were studied of which 14 were hypertonic. Changes of blood sodium, potassium, chloride and bicarbonate were not observed in either group. In the hypertonic patients, blood pressure decreased from a mean systolic value of 168 to 140 mmHg and mean distolic pressure from 105 to 88 mmHg. Observations to date suggest the following indications for a low-mineral content water diet: 1. hypertension, 2. renal insufficiency in stages of compensated and decompensated retention, especially in cases with high serum potassium levels, 3. in the initial therapy of diabetes, gout and obesity; patients with a high water demand should be treated with low-mineral content water until the optimal intake of electrolytes is established.

Blood Pressure↗
PubMed1975

Disaccharidases in rat small intestinal mucosa following cytostatic treatment with adriamycin.

Our studies have shown that appropriate doses of adriamycin can reduce the activities of the intestinal disaccharidases in the rat. At higher doses, in addition to morphological changes in the intestinal mucosa, a considerable fall in disaccharidase activities also occurs. This functional impairment can be seen for a period of several days after the morphological restitution of the mucosa. Appropriate studies of the small intestinal mucosa in man will have to be undertaken to show whether similar impairment occurs at therapeutic doses.

Animals↗
PubMed1975

[Ketone bodies in the blood during sorbitol infusion].

The concentration of hydroxybutyrate and pyruvate during infusion of sorbitol was significantly depressed in 12 healthy subjects. The dosage ranged between 0.25 and 0.50 g/kg BW/h. Considering the blood parameter the hunger ketosis was depressed by the infusion rate of 0.25 g/kg/h. Cholesterol concentration, too, was significantly lowered by sorbitol.

Acetoacetates↗
PubMed1975

[Diurnal variation of glucose tolerance and insulin secretion in man (author's transl)].

The present investigation was designed to determine whether the circadian rhythm of glucose utilization is based on a quantitatively different release of insulin and/or on changing secretory dynamics of the hormone. 22 healthy men received three oral glucose tolerance tests in the morning, afternoon and evening of the same day. The blood sugar levels in the afternoon and evening tests were significantly higher than those found in the morning tests. Also the plasma insulin response was higher in the afternoon than in the evening, but it showed a delayed rise and late peak response. In the evening the normal subjects responded as mild diabetics.

Adolescent↗
PubMed1975

[Serum lipoproteids and ketone bodies after constant infusion of sorbitol i.v. (author's transl)].

20 patients of a metabolic ward received a six-hour infusion of sorbitol at a dosis of 0.125 g/kg/h(n equal to 10) and 0.25 g/kg/h(n equal to 10) body weight. Cholesterol levels showed a significant fall in both groups (p smaller than 0.05) and triglycerides rose significantly (p smaller than 0.05). The concentrations of acetoacetate and beta-hydroxybutyrate were lowered irrespective of the dosis. The cholesterol-reducing effect can be explained by the antiketogenic action, whereas the increase in triglycerides possibly could be the result of raised alpha-glycerophosphate.

Acetoacetates↗
PubMed1975

Suitability of non-glucose-carbohydrates for parenteral nutrition.

Postoperative parenteral nutrition can only be optimally effective if the characteristics of post-traumatic metabolism are taken into account. Two main possibilities are discussed for the carbohydrate component of parenteral nutrition during this phase: glucose with high doses of insulin or non-glucose carbohydrates (sugar substitutes) possibly in a suitable combination with glucose. The risks as well as the technical and organisational problems involved in the use of them are discussed and the authors prefer the second of the two alternatives. Possible side effects of non-glucose carbohydrates are pointed out and it is shown how these can be avoided by observing dose guidelines. So far a combination of frucose : glucose : xylitol in a ratio of 2 : 1 :1 with a total dose of 0.50 g/kg/hour has been studied most thoroughly. This combination normalises the fat metabolism and improves glucose tolerance without requiring exogenous insulin. Experiences with this combination as well as individual non-glucose carbohydrates on operated patients have been given continuously for up to 7 days and in some cases even for several weeks. No side effects, no deviations from a steady state and no abnormal changes of the laboratory values occurred. The authors are of the opinion that non glucose carbohydrates are necessary if the facilities for frequent blood sugar controls are not available.

Adenine Nucleotides↗
PubMed1975

[Metabolic effect of a carbohydrate combination during simultaneous amino acid infusion].

During a period of 12 hours, eight normal subjects were infused with an electrolyte containing combined 24% carbohydrate solution of fructose, glucose, and xylitol at a ratio of 2:1:1 (Triofusin E 1000 Pfrimmer) with a rate of supply of 0.6 gm/kg/h. Lamino acids (Aminofusin L 10% carbohydrate-free Pfrimmer) were simultaneously administered at a rate of 0.1 gm/kg/h. The serum substrate concentrations of fructose, glucose and xylitol and their excretion were measured. The utilization of fructose was 99%, of glucose practically 100% and of xylitol 88%. In accordance with the slight glucose increase, the concentration of insulin also showed an only slight increase. An increased serum concentration of oxalate was not observed. Despite the infusion of a glycine containing amino acid mixture, the excretion of oxalic acid even decreased during the infusion. The dilution effect measured by means of hematocrit, hemoglobin, erythrocyte count, total protein, and albumin was between 2 and 5%. The lactate concentration did not change significantly whereas hydroxy butyrate decreased significantly by the end of the infusion indicating the antiketogenic effect. A disturbance of fat metabolism was not observed as was indicated by the concentrations of neutral fat and cholesterol. The decrease of free glycerol cannot be clearly explained. A highly significant reduction of the serum uric acid concentration resulted from an increased renal elimination. The electrolyte concentrations of potassium, sodium, calcium and phosphate showed only slight modifications. The concentration of potassium initially rose significantly within normal ranges. Sodium and chloride remained constant whereas calcium decreased slightly but not significantly and phosphate decreased significantly until the 12th hour. The serum transaminase and bilirubin concentrations did not show any change. During the permanent infusion, a respiratory alkalosis developed. The average urinary excretion was 134 ml per hour, the excretion of potassium was 6 mEq/h, of sodium 15 mEq/h, and of phosphate 27 mg/h. The utilazation of a combined carbohydrate solution was in the same range with or without the simultaneous application of amino acids. The reduction of the uric acid concentration and the absent increase of lactate, bilirubin and oxalate may be considered as an additional desirable effect of the simultaneous application of amino acids.

Acid-Base Equilibrium↗
PubMed1975

[Studies on the pharmacokinetics of carbohydrates as a basis for their use in parenteral feeding].

Metabolic effects of glucose, fructose, sorbitol, xylitol and their combinations during intravenous application in men were investigated. The totale and metabolic clearance, the renal and metabolic elimination, the half-time and the turnover rate were measured. For all sugars intravenous long-term infusions from six to twelve hours were performed. Up to a dosage of 0.75 g/kg/h for glucose 0.5 g/kg/h for sorbitol and 0.25 g/kg/h for fructose and xylitol a steady state of substrates and metabolites has been found. If these dosage-limits are exceeded during glucose application a hyperglucosemia, after sorbitol a continous rise in sorbitol blood level, during fructose a rise in lactate and during xylitol infusion clinical side effects occurred. It could be shown that during simultaneous application of glucose, fructose and xylitol the utilization of glucose rises whereas the utilization of fructose and xylitol remain on such levels as if these sugar were infused alone.

Adult↗
PubMed1975

[Carbohydrate administration and electrolyte balance in patients under intensive care].

A twenty-four percent solution of carbohydrates 0.2 g/kg/h consisting of fructose, xylit and glucose in a 2:1:1 ratio and an aminoacid solution 0.03 g/kg/h were given to 13 patients of the internal medicine intensive care unit. There was an unimportant loss of carbohydrates, only, with but few exceptions, i.e. a loss of 11% in 3 patients. The results demonstrate that the carbohydrates of the combined solution become utilized independent of each other. The balance of water, sodium, potassium and magnesium were not only negative but also positive. The elimination of calcium was between 1-19 mval/24 h, of phosphate between 0.6-8.7 mval/24 h.

Carbohydrates↗