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Biomedical subjects

F Nissim

Publications and source records attributed to F Nissim.

At least 19 recordsLinked to original sources

An unusual presentation of adenoid cystic carcinoma of the lacrimal gland.

Adenoid cystic carcinoma of the lacrimal gland is a highly malignant tumor usually characterized by symptoms of less than 1 year's duration. Computed tomographic (CT) findings of adjacent bony erosion or focal tumor sclerosis are also suggestive. We present a 57-year-old female patient who manifested symptoms of an enlarging mass in the right lacrimal fossa for almost 3 years prior to the establishment of the diagnosis of adenoid cystic carcinoma. CT findings during those years were not supportive for malignancy. The treatment included en bloc resection of the mass and adjacent bone and radiotherapy.

Carcinoma, Adenoid Cystic↗

[Brucella infection of the testis mimicking malignancy].

A testicular mass is a diagnostic challenge, as it may include both benign and malignant processes. Due to the difficulty in diagnosis and the need to prevent complications, it is sometimes necessary to perform orchiectomy. We present an unusual case of brucellosis in which the presenting features were persistent cough for 6 months and a right testicular mass. The clinical picture and ultrasound findings suggested malignancy. Orchiectomy and medical treatment resulted in rapid resolution of symptoms.

Aged↗

Isolated necrosis of the tubal fimbriae in a prepubertal girl.

A report of haemorrhagic necrosis of the tubal fimbriae in a prepubertal girl is presented. The presumptive aetiology for this is the isolated torsion of the fimbrial end which, to the best of our knowledge, has not been previously described. A high index of suspicion of torsion and early intervention is emphasised. Laparoscopy should usually precede laparotomy in doubtful cases but during laparotomy as little as possible should be done in order to retain future fertility.

Abdomen, Acute↗

Ovarian carcinoma masquerading as ovarian hyperstimulation syndrome.

Two patients receiving ovulation-inducing drugs were found to have ovarian carcinoma. Since patients receiving such medication are prone to develop enlarged ovaries with or without the fully developed hyperstimulation syndrome, the diagnosis of ovarian tumors in such patients may be delayed or missed. It is therefore being suggested that an ovarian enlargement persisting for more than 4 weeks, or the finding of ovarian solid masses by sonography in patients receiving ovulation-inducing drugs, should lead to a thorough work-up for neoplasia, sometimes including even laparotomy.

Adult↗

Crohn's ileitis complicated by amyloidosis: observations and therapeutic considerations.

We present a patient with clinically asymptomatic amyloidosis associated with Crohn's ileitis. A distinction should be made between immunocytic dyscrasia associated with amyloidosis (formerly primary or myeloma-associated amyloidosis) and acquired systemic amyloidosis (formerly secondary amyloidosis). We compare the natural course of amyloidosis complicating Crohn's disease with these complicating familial Mediterranean fever (FMF), and discuss the role of resection and the rationale behind colchicine therapy. Our patient is the first reported case in which colchicine therapy alone has been successful in the prophylactic treatment of amyloidosis complicating Crohn's ileitis.

Adult↗

Noma in a full-term neonate.

Noma is an uncommon gangrenous process usually affecting malnourished children. A full-term neonate with orofacial noma, bilateral choanal atresia, and transient neutropenia with B cell deficiency is reported. This unusual appearance of noma in a well-nourished newborn might be related to the combination of choanal atresia and transient immune deficiency.

Agranulocytosis↗

Retroperitoneal fibrosis in association with urothelial tumor.

One of the less common associations of retroperitoneal fibrosis is malignancy. Although there have been many reports on tumors associated with retroperitoneal fibrosis urothelial tumors are rare. We report a case of retroperitoneal fibrosis and urothelial malignancy of the renal pelvis.

Adult↗

Primary squamous cell carcinoma of the pilonidal area.

Two patients with primary squamous cell carcinoma of the pilonidal area are presented. No chronic infection or any other lesion predisposing to malignant transformation was present in either patient. Physicians and surgeons should be aware of the possibility of skin cancer appearing in this area in elderly patients. Biopsy of the lesion, leading to an early diagnosis, may prompt surgical treatment. Complete excision of the lesion is a prerequisite for cure.

Aged↗

Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.

The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the dihydroxylated metabolites of vitamin D were found to be normal and a pronounced increase was noted 24 hours after injection of 100 000 IU vitamin D2. The study suggests that during the neonatal period a small renal mass is sufficient to maintain optimal circulating levels of the dihydroxylated metabolites of vitamin D.

Dihydroxycholecalciferols↗

A limited form of Churg-Strauss syndrome: ocular and cutaneous manifestations.

A case that supports the concept of a limited form of Churg-Strauss allergic granulomatosis was studied. The patient had a syndrome that was initially confined to the conjunctiva and subsequently displayed cutaneous and subcutaneous lesions. At no time was there any evidence of systemic involvement. Asthma appeared ten years before the onset of the present disease. The characteristic histologic findings consisted of diffuse tissue eosinophilia, and eosinophilic necrotizing and nonnecrotizing granulomatosis. The last, as well as conjunctival involvement, has not been previously described in Churg-Strauss syndrome to our knowledge. Thus, this entity most likely represents a variant of the classic Churg-Strauss syndrome, lacking the multiple organ system involvement that occurs in the latter. The patient responded well to therapy with corticosteroids and as of this writing has been free of disease for about 2 1/2 years.

Adult↗