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Biomedical subjects

F Oberheuser

Publications and source records attributed to F Oberheuser.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Radiotherapy of vulvar cancer. Treatment results of electron therapy in 446 patients 1956 to 1978].

446 patients with malignant tumour of the vulva were treated from 1956 to 1978. In 432 patients with invasive squamous cell carcinoma, a five-year survival rate of 43.1% was obtained after exclusive exposure to electron radiation. Severe complications were seen in 10.9% of the treated patients. On comparing the results with those obtained after electrocoagulation or vulvectomy, it was seen that a therapy based on electron radiation only yielded more favourable results, especially in cases with advanced stage carcinomas. In younger women with early tumour stages, surgery should be given preference.

Aged↗
PubMed1985

[Gynecologic and cytogenetic aspects of prenatal diagnosis in the 1st trimester of pregnancy].

The article reports on a new method in prenatal diagnosis during the first three months of pregnancy. The gynaecological as well as the cytogenetic aspects are discussed on the basis of 74 transcervical trophoblast aspirations. Two different experimental preliminary examination series were conducted. In the first study, the failure rate in respect of recovery of material was 12.5%, whereas in the second examination series all aspirations were successful. Thanks to these favourable results, transcervical trophoblast aspiration was adopted as the only method used in prenatal diagnosis. In cytogenetic processing, direct chromosome preparation was found to be rather costly and time-consuming, whereas the short-term culture of chorionic villi usually yielded more favourable results in respect of mitotic rate and quality of the metaphase plates. It must be considered a drawback of transcervical trophoblast aspiration that it is not possible to conduct alpha-foetoprotein determination or determination of acetylcholine esterase as part of prenatal neural tube diagnosis. However, this can be subsequently done-with suitable disposition--during the 16th week of pregnancy, or can be replaced by a determination of alpha-foetoprotein in the serum of pregnant women.

Abortion, Induced↗
PubMed1985

[Initial results with PAC polychemotherapy in the treatment of advanced recurrent breast cancers].

11 patients with advanced, recurrent mamma cancer were treated by a PAC polychemotherapy. The therapy was well tolerated, the incidence of side effects was low. All patients responded to therapy (7 NED, 3 CR, 1 PR). 2 patients died, one commited suicide, the other died after having developed hepatitis. Of the remaining 9 patients 7 survive recurrence free; medium follow up 20 months. These data are in accordance with results obtained by Kolarić et al. [2] and Forastiere et al. [1] who showed platinum to be effective in the treatment of mamma cancer.

Adult↗
PubMed1983

Effect of smoking on cadmium and lead concentrations in human amniotic fluid.

The amniotic fluids of 155 pregnant women, non-smokers (n = 128) and smokers (n = 27), were investigated on their cadmium (Cd) and lead (Pb) concentrations. The mean +/- s range of Cd in the amniotic fluid of non-smokers amounted to 2.58 +/- 1.36 ng/l, that of smokers to 7.29 +/- 2.39 micrograms/l. Moreover, there was a correlation between the extent of daily cigarette consumption and Cd levels. With Pb, higher concentrations were found ranging between 23.98 +/- 9.41 ng/l for non-smokers and 21.53 +/- 7.16 micrograms/l for smokers. No correlations were seen between age, week of pregnancy, blood pressure, disorders of pregnancy and the amniotic Cd or Pb concentrations. Thus, the maternal and fetal risks of the higher Cd levels in the amniotic fluid of smoking women remain unanswered.

Amniotic Fluid↗
PubMed1983

[Cadmium and lead concentrations in the amniotic fluid of pregnant smokers and non-smokers].

Many studies showed the unhealthy effect of smoking on the fetus. Several mechanisms for the unfavorable effect are discussed. In the last few years interest has been shown in the occurrence of heavy metals such as cadmium and lead in smoke. In animal experiments high doses of cadmium showed mutations, teratogenicity and low doses showed retardation of fetal growth. Amniotic fluid examinations of smoking and non-smoking pregnant women showed that there is no barrier to cadmium from the placenta. A direct correlation between cigarette smoking and cadmium concentration in the amniotic fluid was found. Cadmium was discussed as a reason for hypertension. But this was not verified in our study. There were no correlations between the cadmium and lead content of amniotic fluid and the gestational age, and disturbances of the pregnancy nor a correlation to the incidence of abortions. The lead concentration in the amniotic fluid of smokers and non-smokers showed no significant difference. This is attributed to the ubiquitous exposition to lead with increasing pollution of the environment. The relatively small additional amounts of lead in cigarettes do not increase the amount of lead in the amniotic fluid.

Abortion, Spontaneous↗
PubMed1983

Should blood glucose monitoring be done in overweight and/or giant infants of non-diabetic mothers?

Monitoring of serum glucose levels in 60 asymptomatic overweight (4.000-4.499 g) and giant (greater than 4.500 g) newborns of non-diabetic mothers during the first 72 hours of life did not reveal pathological values. The mean result of giant infants was lower than that of the group less than 4.500 g. In mothers of overweight infants diabetes mellitus should always be kept in mind. However, the diagnosis may be difficult particularly in its latent form due to metabolic alterations caused by pregnancy. For this reason it is necessary to monitor blood glucose levels for hypoglycemia in these newborns just as in infants of mothers having a manifest diabetes mellitus.

Birth Weight↗
PubMed1982

The transcutaneous PO2 measurement as an additional evaluation index to the physiological and pathological conditions under delivery.

Transcutaneous PO2 was continuously recorded from 17 newborns sub partu by normal deliveries and four cases with umbilical cord complications. These data were correlated with the corresponding fetal heart rate alterations and the maximum of contraction directly and 30 s thereafter. During the course of delivery three stages are differentiated: first stage of labor, full cervix dilatation, second stage of labor. The statistical evaluation succeeded in the X2-test (P less than 0.01). Deriving from this result the tcPO2 measurement is an additional aiding procedure beside the cardiotocographic control for subpartal supervision.

Female↗
PubMed1981

[Carcino-embryonic antigen in cases of cervical carcinoma (author's transl)].

Carcino-embryonic antigen (CEA) was determined by means of solid-phase radio-immuno-assay through one year in 83 patients with Groups I through IV cervical carcinoma. The intention was to test CEA diagnosis for its value as tumour marker in therapeutic monitoring and detection of recurrences. CEA values prior to treatment were above normal, that is in excess of 2.5 ng/ml, in 42.8 per cent of the cervical carcinoma patients. CEA values declined during therapeutic radium and cobalt 60 irradiation in 81 per cent of those patients in whom original values had been increased to more than 2.5 ng/ml. No substantive change was recordable from those patients in whom original values had been below 2.5 ng/ml. Recurrence diagnosis gave good agreement between CEA levels and clinical findings in 58 per cent of the cases, falsely negative data in 37 per cent and falsely positive values in four per cent. The development of recurrence was repeatedly sensed by means of CEA determination up to six months before clinical manifestation in 72 patients who had been under long-time monitoring. The usefulness of CEA determination in therapeutic monitoring and after-care of patients with cervical carcinoma was found to be limited to the effect that only increased values were of clinical relevance, whereas no conclusions whatever could be drawn from low values.

Aftercare↗
PubMed1981

Uterine contraction intervals and transcutaneous levels of fetal oxygen pressure.

Continuous intrauterine transcutaneous PO2 (tcPO2) measurement was performed in 30 deliveries. The various characteristics of labor (peak of contractions, duration, and contraction interval) were correlated with the tcPO2 integral. The best correlation was seen between the tcPO2 integral and that of the contraction intervals. As the data show significant correlations with the pattern of labor, continuous tcPO2 measurement is a reliable and sensitive method for recognizing PO2 alterations early, especially in high-risk deliveries.

Female↗
PubMed1979

[The protective effect of piracetam during delivery].

It was evaluated by continuous cardiotocogram-, tcpO2-and EEG-registration sub partu to what extend these parameters are influenced by application of Piracetam (10 g i.v./h) to the mother. A group of 26 primigravida between 18 and 23 years of age with normal course of delivery at term was analyzed. Piracetam was applicated to 17 patients in the beginning of cervix dilatation, whereas the other patients got Laevulose as a placebo infusion. The results permit the conclusion that Piracetam provides a stabilization of cerebral functions with a certain resistence against transient hypoxia during the expulsion period. The EEG-registration demonstrates after application of Piracetam an activation of alpha-waves with simultaneous reduction of delta-waves, the CTG shows a reduced quantity of decelerations during the expulsion period. The data obtained by computerization correlate with the Apgar-Index (fetal outcome) after application of Piracetam, which was better than 9 in all cases.

Adult↗
PubMed1979

[Fetal death in utero 15 weeks following amniocentesis -- a legal case (author's transl)].

This is a report about fetal death in utero in a case of monozygote, monochrionic, monoamnionic twin pregnancy (46,xy) 15 weeks after amniocentesis. The public prosecutor was occupied with the case by the patient. The accusation run as follows: Stab wound with following death in utero of one twin and thereby damage of the second twin also with following death in utero. Directly after delivery the first diagnosis by aspect of the fetuses was: transfusion syndrome. The following endoradiography of the blood vessels of the umbilical chords and placenta confirmed the first diagnosis (anastomosis). Additionally both chords were entangled and knotted variously. It was concluded that the extremely smaller fetus died from malnutrition (transfusion syndrome) whereas the taller fetus died from acute asphyxia (knotted chords in monoamnionic twin pregnancy). The forensic investigation was, as aspected, without any pathological findings concerning sequelae of stab wounds but revealed the lack of one chordvessel of the smaller fetus and the typical histological findings of an aspiration lung of the taller fetus.

Amniocentesis↗
PubMed1979

[Carcino-embryonic-antigen (CEA) in adenocarcinoma of uterine corpus (author's transl)].

Sandwich radio-immune assay was used before, parallel with as well as following surgical and radiation therapies on 73 patients in a follow-up check for an assessment of the clinical value of CEA im adenocarcinoma of the uterine corpus. CEA levels were increased in only 17 per cent of all cases. The strongest drops in CEA levels in correlation with patients' clinical response to therapy were recorded from those probands who had undergone surgery followed by Co60 irradiation. While CEA determination is, generally, recommended for monitoring of therapy and for the detection of recurrent corpus carcinomas, only pathological CEA levels should be considered as being relevant to clinical action, since the rate of false negative values has been as high as 34 per cent.

Adenocarcinoma↗