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Biomedical subjects

F Oberheuser

Publications and source records attributed to F Oberheuser.

At least 55 records · Page 3Linked to original sources
PubMed1978

[Extraamniotic induction of abortion with a new prostaglandin E-2 derivative].

First clinical results are reported of a new prostaglandin-E2-derivative (16-phenoxy-prostaglandin-E2-methylsulfonylamide = SHB 286) as abortifacient using the extraamniotic route of application. Upon investigation in animals this prostaglandin-E2-derivative proved to be more tissue-selective and more potent in inducing abortion than the naturally occurring prostaglandins. Prostaglandin SHB 286(50 or 100 microgram) was applicated to 31 patients for legal abortion and to 7 patients with a missed abortion. The mean instillation-abortion time was 14.2 and 13.7 h respectively. 96% of the patients had a complete or incomplete abortion after 24 hours. Severe local or systemic side effects did not occur and the patients did not need any further medication.

Abortion, Induced↗
PubMed1978

[Surgical refertilization by means of laser technic. Animal experimental study].

Animal experiments on rabbits with a CO2 laser concerning end-to-end-anastomosis of cornua uteri are reported. The rate of success of this laser technique by a before investigated optimal energy density of 64 Watt sec/cm2 (8 Watt,0,2 sec) was about 70% deliveries without any complication. This method could be an alternative to the presently used microsurgical methods of refertilisation in human tubar sterility.

Animals↗
PubMed1977

[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII. Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome].

In preparing a clinical study 14C-labelled bromhexine metabolite VIII was applied intraamnially in animal experiments. The distribution was measured in different maternal and fetal organs by thinlayer chromatography and autoradiography. A complete placental passage was found in both directions. An organspecific accumulation in the fetal lungs could not be demonstrated.

Ambroxol↗
PubMed1977

[Continuous intrauterine pO2 determination in the fetus during birth].

A study about continuous intrauterine pO2-measurement of the human fetus sub partu. It is reported about a continuous intrauterine unbloody pO2-measurement of the human fetus sub partu. There was found a good correlation in different cardiotocographic patterns between labour, fetal heart frequency and pO2-registration.

Adult↗
PubMed1977

[Prevention and therapy of the respiratory distress syndrome in premature infants using lecithin. Distribution of 14C--labeled lecithin after intravenous and intraamnial administration in pregnant miniature pigs?].

The aim of our researches was to point out a new therapeutical possibility to prevent a respiratory distress syndrome of prematures by application of 14C-lecithine. The experiments were carried out at Göttinger mini-pigs. Examining the placental passage it could be determined that an intravenous application was not efficient, while after intraamnial application of lecithine a rapid resorption in the fetal organism was proved. Of special interest was a high accumulation of lecithine in the fetal lung-tissue. These results indicate a possible therapeutical way to prevent a respiratory distress syndrome by lecithine substitution.

Amnion↗
PubMed1977

[Results of irradiation in recurrent collum carcinoma].

From 1961 to 1970 82 patients with recurrent carcinoma of the uterine cervix were treated by Co60 biaxial pendular rotation therapy. The applicated dose was 4000 R, in some cases supplementary radium implants. This method of irradiation is especially suitable for treatment in recurrent cancer by the augmentation of the relative tumor dose. 46 cases were histologically confirmed, the others were parametric recurrences. The 5-year-survival-rate was 20.7%.

Cobalt↗
PubMed1977

[Intraamnial application of 14C-labeled lecithine at man 13 hrs. ante partum (author's transl)].

It was examined, whether by intraamnial applicated lecithine an approaching respiratory distress syndrome could be prevented. This possibility of therapy was tested on a fetus unviable of life. It was shown by examining the lavage-fluid of the fetal lung, as well as the organ homogenates of lung; liver and gut, that the intraamnial applicated lecithine was metabolised and resynthesised in the organism. In the lung the lecithine was present as a complete molecule.

Adult↗
PubMed1977

[Intraamniotic application of lecithin in pregnant rabbits (author's transl)].

In order to find possibilities to influence therapeutically the respiratory distress syndrom at the premature infant animal experiences were carried out with 14C-lecithine. High pregnant rabbits got 14C-lecithine by intraamnial application. Investigation of the distribution of lecithine in the amniotic fluid and in the fetal organism showed an accumulation of lecithine metabolits in lung and lever tissue.

Amnion↗
PubMed1976

[Course observation after intra-amniotic administration of lecithin in premature cesarean section].

A report of a 36 year old patient is given who was hospitalized because of an erythroblastosis. An indicated sectio caesarea resulted in an intraamnial application of lecithine for preventing a respiratory distress syndrome. It can be concluded by the measured lecithin-concentration that a high phospholipid-level in the amniotic fluid leads to an increased resorption by the fetus. Postpartal investigations showed a completely normal lung function in the newborne.

Amnion↗
PubMed1976

[Case study of 14C-labelled lecithin placental transfer].

Because of the clinical and biochemical state of a 26 years old patient an erythroblastosis was expected. Continuous controls revealed that delivery in the 36th week of pregnancy was necessary. A therapeutic research with lecithine through the maternal circulation in this special case was carried out in order to prevent a respiratory distress syndrome of the premature infant.

Adult↗