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Biomedical subjects

F Paille

Publications and source records attributed to F Paille.

At least 37 records · Page 2Linked to original sources
PubMed1992

Alcohol consumption and biological markers for alcoholism in idiopathic dilated cardiomyopathy: a case-controlled study.

The aim of this study was to compare alcohol consumption and biological markers for alcoholism in a population of 23 men (57 +/- 8 years) admitted to hospital with idiopathic dilated cardiomyopathy (DCM), and a control group of 46 men (54 +/- 8 years) with coronary artery disease, matched for age. The DCM group had a higher daily alcohol consumption (82 g/day vs. 30 g/day, P < 0.0002). This difference was greater for the consumption of wine (63 g/day in the DCM group vs. 24 g/day in the control group, P < 0.002). Duration of regular daily alcohol consumption was longer in DCM patients (34 years vs. 22 years, P < 0.01) as well as duration of heavy alcohol consumption (> 60 g/day) (25 years vs. 10 years, P < 0.001). Among the biological markers, only the serum levels of immunoglobulin A were significantly increased in the DCM group (3.7 g/l vs. 2.7 g/l, P < 0.03). In this French population, alcohol is strongly linked to DCM. Biological markers appear to be poor predictors of alcohol intoxication in this so-called 'idiopathic' myocardial disease.

Alcohol Drinking↗
PubMed1991

Outcome of treatment in alcoholic women.

One hundred and seventy-eight females (mean age 40.6 +/- 10.2 years) were retrospectively studied by questionnaires for a mean duration of 46 (17-75) months. Sixty-two percent were married or living maritally. One third were working. The mean alcohol intake was 157 +/- 76 g/day and 57.3% had alcohol dependence for less than 5 years. Twenty-seven patients (15%) were lost to follow-up; out of the 151 remaining patients, 7 (4%) refused to answer and 18 (12%) died. Suicide and alcoholism complications were a frequent cause of death. One hundred and twenty-six questionnaires were obtained. Twenty-eight women (22%) were abstinent. A good outcome determined by the state of alcoholization (abstinence or moderate consumption) and the improvement of quality of life, was found in 44% of patients. Absence of marital life and greater alcohol intake were related to a poor outcome, whereas enrollment in a fellowship of recovering alcoholics was more frequent in abstinent patients. The mortality rate was important in alcoholic females. A number of factors were related to the outcome.

Adolescent↗
PubMed1990

[Food habits in primary dilated cardiomyopathy].

In this prospective study the nutritional profiles of 21 consecutive male hospital in-patients with primary dilated cardiomyopathy were evaluated in order to determine whether these profiles differed from those foodstuff consumed during on week and recording of the daily consumption of alcoholic beverages during the year preceding hospitalisation. The duration of dangerous alcohol consumption (more than 60 g/day) was also recorded. In these 21 patients the mean calorie intake was 3,600 kcal/day, including 500 kcal/day provided by alcohol. The mean nutrient intakes were: proteins 90 g/day, fats 100 g/day and carbohydrates 300 g/day. The daily alcohol consumption exceeded 20 years. Compared with the control population, the patients with primary dilated cardiomyopathy had a diet that was not lacking in calories but showed insufficient fat intake. Alcohol consumption was unquestionably excessive and constituted a major risk factor for this particular disease.

Adult↗
PubMed1990

Abstention from alcohol in dilated cardiomyopathy: complete regression of the clinical disease but persistence of myocardial perfusion defects on exercise thallium-201 tomography.

This case report describes a 43-year-old man with dilated cardiomyopathy reversed by abstention from alcohol over 1 year but with persistence of previous myocardial perfusion defects on exercise thallium-201 tomography. This suggests that despite the near normalization of left ventricular function, a permanent myocardial disease seems to persist.

Adult↗
PubMed1989

Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption.

The potential clinical interest of a new isoform of alanine aminopeptidase (AAP) was examined using polyacrylamide gradient gel electrophoresis. This form, called F-AAP, is more proteolyzed than normal serum AAP. It appears to be associated with many liver diseases and is related to cytolysis, but also to elevated GGT levels. The F-AAP form was present in 52% of subjects treated with anticonvulsant drugs and in 64% of subjects consuming more than 44 g of alcohol per day. Analysis of F-AAP may be of interest in detecting effects of drugs and alcohol on the liver.

Adult↗
PubMed1989

Tianeptine and its main metabolite pharmacokinetics in chronic alcoholism and cirrhosis.

The effect of chronic alcoholism (with or without associated moderate cirrhosis) on the disposition of the antidepressant tianeptine, which is devoid of substantial first-pass metabolism, was examined in 21 patients and 11 age-matched controls. Pharmacokinetic parameters for tianeptine and its C5 acid analogue metabolite (MC5 metabolite) were estimated by non-compartmental analysis. The area under the curve (AUC) for tianeptine, following a 12.5mg single oral dose, was decreased by 31% in chronic alcoholics and increased by only 14% in cirrhotics, compared to controls. These changes did not attain statistical significance. The trend of changes in the AUC for the MC5 metabolite was similar to that observed for the parent drug. No statistical difference was found in the terminal half-life for both tianeptine and its MC5 metabolite between patients and controls. On the basis of this study, it appears unnecessary to modify the proposed dosage regimen used in clinical trials (tianeptine sodium salt 12.5mg 3 times daily) in chronic alcoholics with or without associated moderate cirrhosis.

Adult↗
PubMed1989

[Dog bites and infection from bacterial inoculation. Necessity for appropriate therapeutic measures].

The most recent statistics in France underline a doubly increasing preoccupation: the alarming rise in the frequency of bites by dogs (watchdogs or lapdogs), and the great number of pathogenic bacteria isolated from the bite wounds. During the last three years (1985, 1986, 1987), the Bacteriological Laboratory of Nancy received 390 samples, and 56% of them contained one or more bacteria. These bacteria basically were Pasteurella (61%), but other different species were isolated and identified recently: for example, the bacterial groups EF4, M5, IIj and especially DF2. The clinical feature is usually a wound which, neglected, is suppurating. But the bacteria of the DF2 group lead to general complications, very serious: more than 50 cases of septicemia have been published. In such cases, the notion of underlying pathology is important: alcoholism, cancer, splenectomy. Therefore, this new threat calls for great vigilance: curative treatment with antibiotic therapy adjusted to the isolated and tested bacterium; but, after all bites by a dog, real prophylaxis is systematically essential, with classical actions and antibiotic therapy (betalactamine or cycline) if the organism of the patient is deficient.

Animals↗
PubMed1988

Micro-scale two-dimensional electrophoresis of alkaline phosphatase from serum.

Isoenzymes of alkaline phosphatase (EC 3.1.3.1) were separated by micro-scale two-dimensional electrophoresis, with isoelectric focusing in capillary gels in the first dimension and polyacrylamide gradient-gel electrophoresis in the second. The isoenzymes detected were identified by several treatments--e.g., incubation with sialidase, papain, Triton X-100, and wheat-germ agglutinin--and by comparison with alkaline phosphatase from liver microsomes. Liver and bone isoforms in normal sera showed overlapping isoelectric points but differed in molecular mass, estimated as 172 and 185 kDa, respectively. Sera of patients with liver disease showed several additional groups of alkaline phosphatase isoforms, two of which were found to consist of multi-molecular complexes. Others probably correspond to incompletely glycated enzyme proteins. A further isoform with a mass of about 250 kDa does not seem to correspond to any known isoform of alkaline phosphatase in serum. With this technique, we demonstrated intra- and interindividual variations of the placental alkaline phosphatase isoenzyme in pregnancy sera.

Adult↗
PubMed1986

[Therapy and suggestion].

Therapy and suggestion are closely related. That is clear for the ancient time: primitive medicine gives a good place to the Word. In plant, animal or mineral remedies, the suggestion is clearly preponderant. Towards the end of the 19th century, the "Ecole de Nancy" sets up a real theory of the suggestion, and Bernheim, its leader, bases hypnosis, then psychotherapy on this concept. Thereafter Coué will bring up the "conscious autosuggestion". Today, despite the progress of scientific medicine, the part of suggestion is still very important in medical therapy (with or without drugs), or in chirurgical therapy; this part is also very important in psychotherapies, whatever has been said in this field. This has to be known and used consciously in the doctor-patient relation, which is always essential in the therapeutic effectiveness.

Autosuggestion↗
PubMed1986

[Arteriography of the hand in Raynaud's phenomenon].

Analysis of 356 angiographic images of hand from 216 patients with Raynaud's phenomenon confirmed the higher prevalence of occlusive arterial lesions (75% of cases) when compared with idiopathic Raynaud's syndrome. The ulnar artery (30% of cases) and digital collateral arteries of free borders of hand (45 to 62% of cases) were the most frequently affected. This preferential localization of the arterial thromboses can be explained by repeated microtrauma from manual occupations (markedly increased in cases of digital arteriopathy). Correlation between the occlusive lesions and a thoracic outlet syndrome is lacking.

Adolescent↗