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F Paille

Publications and source records attributed to F Paille.

44 records · Page 3Linked to original sources

[Current concepts on therapeutic possibilities in alcohology].

Therapeutic possibilities in the field of alcoholism are certainly more extensive than accepted by most general practitioners and internists whose attitude is, according to an inquiry, rather fatalistic. The actual therapy of alcoholism proves to be effective, the earlier the therapy being started the better are the results. On this account, the necessity of preventive measures and of an early treatment is to be underlined. General practitioners and internists (whose training in this area appears to be still deficient) as well as centers for nutritional hygiene and alcohology (presently about 200 consultation centers in France) may play here a cardinal role. The treatment of alcohol-addicts often justifies hospitalisation, more and more in general hospitals, where a therapeutic program, at the first place a long-term psychotherapy, is set up. The alcoholic should constantly be assisted by his treating physician, by specialised centers and also by fellowships of former alcohol-addicts.

Alcoholism↗

[Lipids and lipoproteins in chronic alcoholism. Outcome after alcohol withdrawal].

The plasma lipids and lipoproteins changes observed in chronic alcoholic subjects and their modifications after cessation of drinking were studied in 379 patients admitted for alcohol withdrawal. The modifications were evaluated after one month (n = 348), 6 months (n = 56) and one year (n = 29) of abstinence. A significant decrease of HDL-cholesterol and apo A-I levels was noted after one year. HDL-cholesterol, apo A-I and apo B showed a biphasic variation with significant post-withdrawal changes which became less pronounced after 6 months of abstinence. The authors insist on the need for a prolonged post-withdrawal monitoring of plasma lipoproteins and apolipoproteins levels to evaluate the consequences of cessation of major chronic alcohol abuse. This study shows that the variations of plasma lipids and lipoproteins levels observed in heavy drinkers are similar to those observed in moderate drinkers, whereas the incidence of cardiovascular diseases seems to be higher in the former than in the latter.

Alcoholism↗

[The prescription and drug interactions: prospective study in 896 patients treated for arterial hypertension in general medicine].

The aim of this study was to investigate the occurrence of potential drug interactions in primary health care. It reports the analysis of 896 prescriptions for hypertensive patients collected from 237 general practitioners. The mean number of prescribed drugs was 4.55 +/- 2.14, and each patient received, on average, 1.92 +/- 0.92 antihypertensive drugs. All prescriptions were compared with a French computerized database of drug interactions (Micro-Vidal). A total of 1324 cases of potential drug interactions were found related to 552 patients (61.6 pour cent). Among the most dangerous interactions, there were 26 contra-indications and 168 unsuitable drug pairs. As reported in previous studies, there was a strong correlation between the number of prescribed drugs and the number of interactions. All in all, more than 16 per cent of prescriptions contained a contra-indication or unsuitable drug association. Potential drug interactions occur at a high rate in general practice. This raises questions about the best way to improve general practitioner training and to introduce preventive measures to reduce adverse drug effects.

Antihypertensive Agents↗