Biomedical subjects
Publications and source records attributed to F Paquet.
This study evaluated influences of time of administration on the response to allergy skin prick tests. There was no significant difference between the mean +/- SEM wheal diameter of positive responses obtained in the morning, 2.98 +/- 0.19 nm, or in the evening, 3.14 +/- 0.18 mm (n = 175).
Benzyl 2-azido-2-deoxy-beta-D-galactopyranoside was converted into benzyl 2-azido-4,6-O-benzyl-2-deoxy-beta-D-galactopyranoside via benzylidenation, p-methoxybenzylation, acid hydrolysis, benzylation, and selective oxidation. Condensation of 1,2,3,4,6-penta-O-acetyl-beta-D-galactopyranose with benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-beta-D-galactopyranoside in the presence of trimethylsilyl triflate gave crystalline benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-ga lactopyranosyl)-beta-D-galactopyranoside (76%), which was converted into benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,6-di-O-benzyl-beta-D-galactopy ranosyl)-beta-D-galactopyranoside and condensed with 3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide in the presence of silver silicate on alumina and molecular sieve 4 A to give 61% of benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-beta-D-galactopyranosyl)-(1----4)- O-(2,6-di- O-benzyl-beta-D-galactopyranosyl)-(1----3)-2-azido-4,6-di-O-benzyl-2-deo xy- beta-D-galactopyranoside. Reduction with sodium borohydride followed by N-acetylation, O-deacetylation, and catalytic hydrogenolysis then gave O-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-(1----4)-O-beta-D-gal actopyranosyl-(1----3)-2-acetamido-2-deoxy-D-galactopyranose, the desialylated human Cad-antigenic determinant.
The authors report their experience of spine fusion in the management of fracture dislocations of the thoracic and lumbar spine. In a series of over a hundred surgical stabilization, plate instrumentation alone was orthopedically unsuccessful in 20% of cases after plate removal. Instrumentation is but a tutor, whereas spine fusion is an element which brings definite spine stability. Clinical and roentgenographie results are given. Based on the different types of spine injuries, indication are discussed as well as surgical approach and technique with a possible association of several methods applied to the same patient.