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F Pavanetto

Publications and source records attributed to F Pavanetto.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Anticryptogamic activity of some aryl esters of N-benzyldithiocarbamic acid].

Some aryl esters of N-benzyldithiocarbamic acid, characterized by the presence on the S-aryl group of hydrophilic or potentially hydrophilic groups were studied for anticryptogamic activity in vitro and in vivo. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results showed the anticryptogamic activity of acylation derivatives of N-monosubstituted thiosalicylamides with the acyl of N-benzylthiocarbamic acid.

Animals↗
PubMed1983

[Aryl esters of N-benzyldithiocarbamic acid with antimycotic activity].

Some aryl esters of N-benzyldithiocarbamic acid [substances (I leads to XVI)], in which S aryl substituents were hydrophylic or potentially hydrophylic groups, were tested for in vitro antifungal activity against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results, given in Table I, show the marked activity as antifungal agents of the N-benzyldithiocarbamic acid aryl esters studied; the antifungal activity, connected with the N-benzyldithiocarbamic group, is only slightly influenced by the nature of the substituents.

Antifungal Agents↗
PubMed1982

[Benzenedithiol esters with antimycotic activity].

Some diesters of benzen-1,2-dithiol wit aliphatic and aromatic carboxylic acids were prepared and tested for in vitro antifungal activity. The diacetate and dipropionate of benzen-1,3- and 1,4-dithiol were used as comparison compounds. The substances (Table I; substances I leads to X) were obtained by condensation of benzenedithiols with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following fungal strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diester of benzen-1,2-dithiols with alkanoic acids (Table I) have marked antimycotic activity, much greater than that of clotrimazol. The diaroyl esters of benzen-1,2-dithiol and the diesters of benzen-1,3- and 1,4-dithiols are inactive or only slightly active.

Antifungal Agents↗
PubMed1982

[Acaricidal, chemosterilant and insecticidal activity of triazine derivatives].

A large number of 1-aryl-3,3-dialkyl triazenes and 1,2-diphenyl triazenes variously substituted in the 3 position with OH and alkyl groups were prepared and studied for acaricide activity against Panonychus ulmi and chemosterilizing and insecticidal activity against Musca domestica. The results highlighted the marked chemosterilizing activity of 1-(2-methoxyphenyl)-3,3-di-n-propyltriazene and the interesting acaricidal activity of 1-(4-benzoylphenyl)-3,3-dimethyltriazene. The examination of such a large number of compounds for insecticidal activity allowed interesting conclusions to be drawn regarding structure/activity relationships.

Acari↗
PubMed1982

[Antifungal activity of diesters of 2-mercaptobenzene methanethiol].

Some diesters of 2-mercaptobenzenmethanthiol and of 2-(2-nitrophenyl)-1,3-benzodithiyne were prepared and tested for in vitro antifungal activity. The substances [Table I: substances (I leads to VIII)] were obtained by condensation of 2-mercaptobenzenmethanthiol with suitable reagents. The antifungal activity of the products was tested in vitro against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. It was found that antimycotic activity is shown by only some of the diesters of 2-mercaptobenzenmethanthiol with acyl alkylthiocarbamic groups (Table I). The diesters with aliphatic, aromatic, alkylcarbamic groups and the 2-(2-nitrophenyl)-1,3-benzodithiyne are inactive or only slightly active.

Antifungal Agents↗
PubMed1981

[Antifungal activity of 3,3'-diindolyl-2,2'-tetrasulfide].

The compound 3,3'-diindolyl-2,2'-tetrasulfide was studied for in vitro and in vivo fungistatic activity against various fungi causing human and plant diseases. The compound showed marked activity in vitro especially against dermatophytes and in the agrarian field against Botrytis cinerea. When the low phytotoxicity of the compound is taken into account, it is concluded that the compound has considerable potential as an anticryptogam.

Animals↗
PubMed1980

[Preparation and study of the antimycotic activity of 2-substituted 1,3-benzodithiols].

A series of 1,3-benzodithiols substituted at position 2, obtained by condensation of benzene 1,2-dithiols with aldehydes and ketones, was studied for antifungal activity. The fungistatic activity of the compounds [Table I, II; (I leads to XXV)] was tested in vitro against the four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results indicate at the 2-monosubstituted 1,3-benzodithiols are an interesting class of antifungal substances, the 2-phenyl substituted derivative (1) being of particular interest.

Antifungal Agents↗
PubMed1980

[Thiocarbamic and carbamic esters of benzenedithiols with antimycotic activity].

o-, m- and p-phenylen esters of some dithio and thiol carbamic acids N-monosubstituted were prepared and tested for in vitro antifungal activity. The substances studied [Tables I leads to III; substances (I leads to XXI) were all new and were prepared by the reaction of benzenethiols with suitable isothiocyanates or isocyanates. The fungistatic activity of the products was tested in vitro against the four following strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diesters of N-monosubstituted carbamic acids of benzen-1,2-dithhiol (Table I) have marked antimycotic activity, of the same order or greater than that of clotrimazol. Among the thiocarbamic and carbamic diesters of benzen-1,3- and 1,4-dithiol, the most active are the N-benzyl- and N-beta-phenyethyldithiocarbamic derivatives.

Antifungal Agents↗
PubMed1980

[The antimycotic activity of acyl derivaties of 2-oximino-1,3-benzodithiol].

A series of esters of 2-oximino-1,3-benzodithiol [substances (II leads to XV)] was prepared and tested for antifungal activity in vitro. The substances were obtained by condensation of 2-oximino-1,3-benzodithiol with suitable acylation agents. The fungistatic activity of the products was tested in vitro against the four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results reported in the Table I show the interesting antimycotic activity observed for 2-oximino-1,3-benzodithiol, which is apparently connected with the presence of a free oximino group.

Antifungal Agents↗
PubMed1979

[S-Acyl derivatives of thiosalicylamides with antifungal activity. III].

Some S-acylderivatives of N-monosubstituted amides of thiosalicylic acid in which the N substituents were unsaturated alkyl groups, cyclic or branched saturated alkyl groups, aromatic or aralkyl groups, were prepared and tested for antifungal activity. The substances which were all new were prepared by condensation of 2-mercapto-N-alkylbenzamides with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following: Candida albicans and Trichophyton mentagrophytes. The results reported in Table I underline the importance of the S-acylderivatives of N-monosubstituted amides of thiosalicylic acid as antifungal agents. Study of the results in Table I has also given some insight on the structure-activity relationships. The S-acyl-N-aralkylthiosalicylamides proved the most active of the compounds tested.

Antifungal Agents↗
PubMed1979

[S-acyl derivatives of thiosalicylamides and their anti-fungal activity. IV].

Some S-acyl derivatives of N-alkylthiosalicylamides [Table I, II: substances (I leads to XXXIII)] in which the acyl group on S in a carbamic or thiocarbamic N-monosubstituted group were prepared and tested in vitro for antifungal activity. All the substances which are not previously recorded were prepared by condensation of 2-mercapto-N-alkylbenzamides with suitable isocyanates or isothiocyanates. The fungistatic activity of the products prepared was tested in vitro against the two strains: Candida albicans and Trichophyton mentagrophytes. The results (Table I and II) show that the N-monosubstituted S-carbamoyl and S-thiocarbamoyl derivatives of N-monosubstituted amides of thiosalicyclic acid have marked in vitro antimycotic activity. Many derivatives have activity of the same order of magnitude as that of clotrimazole and of these the most active compound is 2-(N-phenylcarbamoylmercapto)-N,n-heptylbenzamide (XXVI).

Antifungal Agents↗
PubMed1979

[Preparation and antifungal activity of carbamic and thiocarbamic esters of thiophenols].

A series of N-substituted carbamic and thiocarbamic esters of thiophenols [substances (I leads to XLII)] was prepared and tested for in vitro antifungal activity. The substances were obtained by condensation of thiophenols with suitable isocyanates and isothiocyanates. The antifungal activity of the products was tested in vitro against the following strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results obtained, given in the Table I, show that the carbamic and thiocarbamic esters of the thiophenols examined have marked antifungal activity. The results give some information on structure-activity relationships and also show that in general the derivatives of dithiocarbamic acid are more active than the bioisosteric derivatives of thiocarbamic acid. Of the compounds examined the most active were esters of N-benzyl and N-allyldithiocarbamic acid.

Antifungal Agents↗
PubMed1978

[S-acylderivatives of thiosalicylamides with antifungal activity. I].

A series of S-acylderivatives of N-ethylthiosalicylamide (substances I leads to XXIII) was prepared and tested for in vitro antifungal activity. The substances, not previously reported, were prepared by the reaction of 2-mercapto-N-ethylbenzamide with suitable acylating agents. The fungistatic activity of the prepared products was tested in vitro against Candida albicans and Trichophyton mentagrophytes. The results given in Table I show that the S-acylderivatives of N-ethylthiosalicylamides have interesting antifungal activity. From examination of the results (Tables I and II) some information on the structure-activity relationship was obtained. 2-Acetylmercapto-N-ethylbenzamide (I) and 2-propionylmercapto-N-ethylbenzamide (III) proved the most active of the compounds tested.

Antifungal Agents↗
PubMed1978

[S-Acyl derivatives of thiosalicylamides having antifungal activity. II].

Some S-acyl derivatives of N-alkylthiosalicylamides [Table I: substances (I leads to XXXI)] were prepared and tested for antifungal activity. The substances, most of which had not been previously reported, were prepared by condensation of 2-mercapto-N-alkylbenzamides with suitable acylating agents. The antifungal activity of the compounds was tested in vitro against Candida albicans and Trichophyton mentagrophytes. For some compounds the was tested activity against the above strains fungicidal, Candida tropicalis and Saccharomyces cerevisiae. Many of the compounds proved to have high antifungal activity comparable with that of Clotrimazol. The results extended knowledge on the structure-antifungal activity relationships of this class of compounds. The compounds with the highest antifungal activity were: 2-acetylmercapto-N,n-heptylbenzamide (XXVIII); 2-acetylmercapto-5-Cl-N,n-propylbenzamide (XIV); 2-acetylmercapto-N,n-octylbenzamide (XXXI); 2-acetylmercapto-N,n-pentylbenzamide (XXV); 2-acetylmercapto-N,n-hexylbenzamide (XXVII).

Antifungal Agents↗