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Biomedical subjects

F Pizzetti

Publications and source records attributed to F Pizzetti.

At least 19 recordsLinked to original sources
PubMed1995

[Surgery of abdominal aortic aneurysms in octogenarians. Critical remarks on indications for surgical intervention in different age groups].

Following the increased frequency of surgery for aortic abdominal aneurysm, due to increasing population age and to improved surgical and anaesthesiological techniques, results in octogenarians are presented and compared. The analysed data derive from 809 consecutive patients operated between January 1987 and December 1993. These have been divided into three age groups: group A = under 65 years, group B = from 65 to 79, group C = from 80 to 93. For each group surgery has been divided in planned operations (symptomatic and asymptomatic cases) and emergency operations (performed after aneurysm rupture) and results are compared. Surgery has been performed as an emergency in 8.6% of cases of group A, in 18.4% of group B and in 41.3% of cases of group C. Death rate in the three groups was respectively of 1.78%, 1.90% and 4.68% for planned operations and 12.50%, 32.63% and 46.67% for the emergency operations. These data confirm the experience of other Authors and indicate that age factor must not be considered a controindication for planned surgery. The importance of this factor in emergency surgery, the greater frequency of ruptures with increased age and the quality of the results in planned surgery suggest a widening of the indications for surgery: the aneurysm transverse diameter of 5 cm, as a minimal measure for planned surgery, must be reconsidered.

Age Factors↗
PubMed1993

[The noninvasive quantitative evaluation of the acute hemodynamic effects of sublingual and transdermal nitroglycerin in man].

BACKGROUND: Organic nitrates are complex vasodilators: the hemodynamic action of these drugs is different in the venous and arterial resistance and capacitance beds. The aim of our study was to obtain a quantitative, noninvasive evaluation of the acute effects of sublingual and transdermal (td) nitroglycerin (NTG). METHODS: Twenty-one pts (mean age 49 years) underwent strain-gauge plethysmography and digital photoplethysmography under control conditions, 5 min after sublingual NTG (0.4 mg), 1 hour thereafter and 2 hours after NTG td (10 mg patch). Forearm venous capacitance (CV, ml.100 ml-1) and arteriolar resistance (RA, mmHg.ml-1.100 ml.min) and the b/a ratio of arterial pulse wave (%) were measured. RESULTS: After sublingual NTG, CV increased (+24%, p < 0.01) and b/a was reduced (-35%, p < 0.01), while heart rate and RA increased (+9% and +36% respectively, both p < 0.01). Two hours after NTG td, CV increase was not statistically significant (+11%, p = 0.056), b/a was reduced (-31%, p < 0.01), heart rate and RA did not change. CONCLUSIONS: The combined use of plethysmography and digital photoplethysmography is suitable for the evaluation of vasoactive drugs such as nitrates, which have a complex profile of action on arterial and venous beds. By this method we have shown that NTG td 10 mg dilates venous beds to a low extent; this approach will be utilized in future studies aimed at elucidating dose-response and regimen effect of these drugs.

Administration, Cutaneous↗
PubMed1975

Staging laparotomy in non-Hodgkin's lymphomata.

Staging laparotomy was performed in 106 selected untreated adults and in 6 children. In adults the histological pattern at initial biopsy was interpreted as nodular lymphoma in 33% and as diffuse lymphoma in 67%. Diffuse histiocytic was the most frequently observed histological subtype in the present series (54%). Diffuse undifferentiated lymphoma was noted in 2/6 children. Waldeyer's ring involvement was noted in 27% of adult patients. Systemic symptoms were present in 7%. Surgery detected occult lesions in 27% of patients (para-aortic nodes 3%, spleen 12%, liver 12%, coeliac nodes 15%, splenic hilar nodes 26%, mesenteric nodes 15%, gastrointestinal tract 1%, bone marrow 12%). The chance of detecting splenic and hepatic involvement was definitely higher in patients with nodal disease above and below the diaphragm in comparison with those with either supra-diaphragmatic or infra-diaphragmatic adenopathy. Lymphography yielded a 96% accuracy proving once more to be a sufficiently reliable diagnostic method. Staging laparotomy is a useful procedure in non-Hodgkin's lymphomata in order to gain information on the natural history and to plan treatment. It remains to be determined whether findings observed through surgical staging will lead to improved treatment and survival.

Adolescent↗