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Biomedical subjects

F R Venezio

Publications and source records attributed to F R Venezio.

33 records · Page 2Linked to original sources
PubMed1984

Incidence of subclavian dialysis catheter-related infections.

Since 1981, we have performed more than 1,300 dialyses in 74 patients who have had subclavian dialysis catheters (SDCs) in place for a total of 3,065 days. Sixty-one (82%) of these patients have had their SDCs in place for seven to 21 days, including 37 (50%) for longer than 21 days. We have had six culture-proved and three possible (culture-negative) cases of SDC-related infections. Staphylococcus aureus (four cases) and Staphylococcus epidermidis (two cases) were the only organisms isolated. These infections were easily managed with antibiotics and removal of the SDC. There were no infection-related deaths. We believe that the SDC is a safe means of administering hemodialysis.

Aged↗
PubMed1983

A case of cutaneous tuberculosis: primary or secondary?

A case of cutaneous tuberculosis in a 24-yr-old Mexican man occurring after a penetration injury is presented. Classification and pathogenesis of cutaneous tuberculosis are reviewed. The disease in the patient described had features overlapping the classification schemes, and the exact pathogenesis remains unclarified.

Adult↗
PubMed1983

Osteomyelitis of the clavicle after Swan-Ganz catheterization.

Osteomyelitis of the clavicle is an uncommon complication of Swan-Ganz catheterization. The diagnosis should be suspected when the clinical features of fever and sterno-clavicular pain are present. Traditional roentgenograms may be falsely normal early in the disease. Radioactive isotope scanning may be helpful in establishing the diagnosis sooner, followed by tomography or computed tomography to better define the abnormality. Therapy should include long-term parenteral antibiotics and possible surgical removal.

Cardiac Catheterization↗
PubMed1982

Complications of mastoiditis with special emphasis on venous sinus thrombosis.

Two children with intracranial venous sinus thrombosis complicating mastoiditis prompted review of the experience with these disorders at the The Children's Memorial Hospital in Chicago over the past decade. Fifteen patients, 1.5 to 14 years of age, with mastoiditis were identified, including nine cases categorized as acute and six as chronic, the latter without fever but with chronic otorrhea. All six patients with chronic, but none with acute, mastoiditis were found to have cholesteatomas. Venous sinus thrombosis developed in four children and intracerebellar abscess in one child. Contrast-enhanced computerized tomography has proved valuable in the diagnosis of these rare, serious complications of mastoiditis in recent patients. Arteriography is still desired to confirm venous patency or occlusion prior to surgery because of well-documented developmental variations in venous drainage patterns. Optimal therapy of mastoiditis and its complications generally requires surgical drainage in addition to administration of antibiotics.

Adolescent↗
PubMed1982

Progressive cutaneous protothecosis.

The diagnosis of severe progressive cutaneous protothecosis in a 34-year-old woman was made by skin biopsy and culture. Analysis of host defense mechanisms revealed a persistent defect in the ability of the patient's PMN to kill the infecting organism. Specific IgG and IgE antibody was demonstrated. Serum levels of complement and immunoglobulins were normal or elevated. The patient was not anergic and peripheral blood lymphocytes responded to nonspecific mitogens. Treatment with amphotericin B and tetracycline resulted in resolution of skin lesions and negative cultures.

Adult↗
PubMed1982

The adherence of polymorphonuclear leukocytes in patients with sepsis.

Adherence of polymorphonuclear leukocytes (PMNLs) to nylon in patients with bacteremia was studied using a whole-blood assay. Adherence of PMNLs was studied in blood obtained from patients who were not in shock; the results did not differ from the control values (70.9% +/- 4.9% vs 72.1% +/- 2.8%, respectively; P greater than 0.3). Adherence of PMNLs in the whole blood of patients was studied 24-36 hr after antibiotic therapy was begun for documented bacteremia, and elevated values were demonstrated (79.2% +/- 8.6%; P less than 0.01). patients with bacteremic shock had a greatly augmented level of PMNL adherence (91.1% +/- 8.5%; P less than 0.001), and enhanced adherence was demonstrated when the normal PMNLs were suspended in plasma from hypotensive patients. The administration of methylprednisolone significantly reduced the adherence of PMNLs in the whole blood of four patients with bacteremia. Assay of PMNL adherence to nylon is a simple test with the potential of identifying bacteremic patients who are at risk of developing shock.

Adult↗
PubMed1982

Infective endocarditis in a community hospital.

Recent reviews from major university centers of infective endocarditis have stressed an increase in unusual infections owing to virulent pathogens. This article compares the 40 episodes of infective endocarditis at a community hospital complex with the recent literature. It was observed that the majority of infecting microorganisms were penicillin-susceptible streptococci similar to those seen in the early antibiotic era. An older patient population was encountered, but overall mortality was low. Streptococcus bovis was a frequent cause of both natural and prosthetic valve infections. Symptoms lasting longer than two months were associated with vegetations demonstrated by echocardiography and high morbidity. Clinical features in this series that significantly correlated with a poor prognosis were height of fever at admission, the failure of fever to resolve within one week of appropriate therapy, the degree of peripheral leukocytosis, gross hematuria, and CNS signs. Conservative parenteral treatment closely monitored by serum bactericidal levels was employed. No relapses occurred among patients surviving initial therapy.

Aged↗
PubMedDate not supplied

In vitro activity of lomefloxacin against multiply resistant Pseudomonas aeruginosa, Enterobacter cloacae, and Staphylococcus epidermidis.

Lomefloxacin is a promising new difluorinated quinolone with good antimicrobial activity and favorable pharmacokinetic properties. The in vitro activity of lomefloxacin was compared to other quinolones, expanded spectrum beta-lactams, and gentamicin. The lomefloxacin MIC90 against multiply resistant strains of P. aeruginosa was 4 mcg/ml, comparable to norfloxacin and ofloxacin. Lomefloxacin was also active against methicillin-resistant S. epidermidis and JK corynebacteria. The role of lomefloxacin in the treatment of infections caused by multiresistant organisms remains to be determined in clinical trials.

Anti-Infective Agents↗
PubMedDate not supplied

Patients receiving quinolones and cyclosporine after heart transplantation.

Six patients required fluorinated quinolone therapy for a variety of infections after heart transplantation. In contrast to findings in a previous report, none of the patients showed any evidence of nephrotoxicity or required a significant change in cyclosporine dose during the treatment period.

Bacterial Infections↗
PubMedDate not supplied

Survival of a heart transplant recipient after pulmonary cavitary mucormycosis.

Pulmonary infections can be a major complication of heart transplantation. Bacterial pneumonia has decreased markedly in the last few years among heart recipients receiving cyclosporine as immunosuppressive therapy. Fungal infections of the lung can cause serious problems in the compromised condition of these patients, with several deaths attributed to Aspergillus and Candida. To our knowledge, however, there has been no report of pulmonary mucormycosis in heart transplant recipients. We describe, therefore, a heart transplant patient with insulin-dependent diabetes mellitus who developed serious cavitary pulmonary mucormycosis. Diagnosis was made by transbronchial biopsy, and treatment required both prolonged administration of amphotericin B and surgical resection to effect a cure. The diagnostic problems and therapeutic considerations associated with pulmonary mucormycosis are discussed.

Amphotericin B↗