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Biomedical subjects

F Rank

Publications and source records attributed to F Rank.

At least 55 records · Page 3Linked to original sources
PubMed1985

Probability of false negative nodal staging in conjunction with partial axillary dissection in breast cancer.

There is a risk of overlooking lymph node metastases and thereby contributing to inaccurate nodal staging when performing partial axillary dissection in conjunction with total mastectomy in female breast cancer. The Danish Breast Cancer Cooperative Group (DBCG) analysed this risk in a prospective nation-wide adjuvant trial dealing with primary operable breast carcinoma. The series comprised 3114 patients, initially found to have lymph node negative axillae, followed for a median of 24 months (quartiles 12-40). It was found that the probability of early ipsilateral axillary relapse of cancer, estimated by means of the life table method, decreased with the number of nodes removed. After 2 years the recurrence rate was 12 per cent for patients with no lymph nodes removed, 7 per cent with one or two nodes removed and 2 per cent with three or more nodes removed. It is concluded that the risk of false negative nodal staging in conjunction with partial axillary dissection is modest, provided at least three lymph nodes are removed and found to be negative on histological examination.

Adult↗
PubMed1985

Transperineal fine needle biopsy of gynecological tumors guided by transrectal ultrasound: a new method.

Six patients had transperineal fine needle biopsy of a pelvic mass performed guided by transrectal ultrasound. Five patients following treatment for gynecological cancer with inconclusive gynecological palpation had a transrectal ultrasound examination performed because abdominal ultrasound did not disclose abnormality. One patient with low back pain had a pelvic mass disclosed with abdominal ultrasound and was referred to transrectal ultrasound for biopsy. In all cases a pelvic lesion was visualized with transrectal ultrasound and transperineal fine needle biopsy was performed. In five cases sufficient material for cytological as well as histological evaluation was obtained showing malignant disease. In one case only necrotic tissue was obtained and subsequent operation disclosed inflammatory changes. It is concluded that transrectal ultrasound combined with transperineal biopsy is a valuable diagnostic tool in the follow-up of patients treated for gynecological cancer.

Adenocarcinoma↗
PubMed1985

Intrinsic tendon healing. A new experimental model.

A new experimental model was developed to study intrinsic flexor tendon healing in vivo. Segment of flexor tendons from the synovial sheath region of rabbits' forepaw were cut, resutured and placed in a silicone tube, sealed in both ends with a GORE-TEX pericardial patch (pore-size less than 1 micron), fastened with silicone glue. The chamber was left subcutaneously in the back of rabbits for six weeks. At this time the chamber was filled with clear tissue fluid. Histologically and ultrastructurally the tendon demonstrated fibroplasia with cell proliferation and collagen synthesis in spite of the fact that no extrinsic cells could gain entrance into the chamber--a finding supporting the concept of intrinsic healing.

Animals↗
PubMed1985

Nerve regeneration and pharmacological suppression of the scar reaction at the suture site. An experimental study on the effect of estrogen-progesterone, methylprednisolone-acetate and cis-hydroxyproline in rat sciatic nerve.

Pharmacological suppression of the scar reaction was tested as a possible method for improving axonal regeneration after transection and suture of the sciatic nerve of rats. The animals in the experimental groups were systemically treated post-operatively with estrogen-progesterone, methylprednisolone-acetate (Depomedrone) or cis-hydroxyproline. Only in the cis-hydroxyproline treated animals was there a tendency towards a decrease in fibroblastic activity at the suture site after 4 weeks. However, there was no difference in the growth of axons to the distal nerve segment after pharmacological treatment as compared to non-treated animals, when tested 12 weeks post-operatively. The motor nerve conduction velocity was however significantly greater in both the cis-hydroxyproline and the methylprednisolone-acetate groups as compared with the estrogen-progesterone and the control groups. In conclusion, cis-hydroxyproline and also methylprednisolone-acetate may improve the function of regenerating peripheral nerve, while estrogen-progesterone does not seem to have this effect.

Animals↗
PubMed1985

Flexor tenosynovitis (FTS): a risk indicator of abnormal glucose tolerance.

Diabetes mellitus (DM), particularly of long duration and insulin dependent, can be accompanied by a variety of locomotor system disorders. However, musculo-skeletal syndromes can also appear in patients with mild glucose homeostasis disturbances. Sometimes these locomotor complaints may precede the diagnosis of the deranged glucose metabolism and hence give a clue to the underlying glucose homeostasis abnormality. In the present work, glucose metabolism was studied in 39 patients presenting with palmar flexor tenosynovitis (FTS) but without any other rheumatic manifestations. For comparison, glucose homeostasis was also studied in 44 patients with FTS accompanying rheumatoid arthritis (RA). In the first group, 23% had an abnormal oral glucose tolerance test (OGTT), a significantly increased frequency vis-à-vis the 4.5% found in the RA group and vis-à-vis the 5.4% reported for the general population. It is concluded that in the absence of any other rheumatic disease, FTS is a risk indicator of disturbed glucose metabolism and that a simple screening procedure for the purpose of disclosing glucose homeostasis abnormalities is warranted in patients presenting with FTS.

Adult↗
PubMed1982

The elimination of alpha 2-macroglobulin complexes from the arthritic joint. A clinical study in rheumatoid arthritis.

A phagocytic uptake of labeled elastase-alpha 2-macroglobulin complexes by macrophage-like synovial lining cells was demonstrated in rheumatoid arthritics. The appearance and distribution of these phagocytically active cells were similar to those containing immunoreactive alpha 2-macroglobulin. It was concluded that these deposits represented phagocytosed alpha 2-macroglobulin complexes and that the elimination of complexes from the arthritic joint at least partly was effected via local phagocytosis.

Aged↗
PubMed1980

Experimental studies on cellular mechanisms involved in healing of animal and human flexor tendon in synovial environment.

An experimental model is presented to study superficial healing of animal and human flexor tendon in a synovial environment. The results indicate that in a synovial environment a cut and resutured flexor tendon may heal in its superficial parts without adhesion formation. When cell seeding via the synovial fluid is prevented by a dialysing membrane the picture, as revealed by light microscopy, is little changed. When the model is modified so that the central cells of the tendon are exposed to the synovial fluid, these cells become activated. The results indicate that superficial as well as deep cells of the tendon possess a potential for repair if they are adequately nourished, and that cell seeding plays no major role in the process of proliferation and repair. The picture of intrinsic repair potential in a synovial environment seems to be valid also for human flexor tendons.

Animals↗
PubMed1980

Superficial repair of severed flexor tendons in synovial environment. An experimental, ultrastructural study on cellular mechanisms.

Severed and subsequently sutured rabbit flexor tendons were kept free and isolated in the synovial cavity of the knee joint. In one series the tendon specimens were surrounded by a dialyzing membrane to avoid cell seeding from the synovial fluid. At different intervals of time over a period of 3 weeks, the tendons were studied morphologically with special reference to scanning electron microscopy. Adhesions were not observed and, with synovial fluid as the nutrient medium, the tendons showed an intrinsic ability to repair in the superficial layers, also bridging the suture gap. Moreover, cell seeding, mainly of macrophages, from the synovial fluid could be demonstrated on the very surface of the tendon. When this cell seeding was prevented, the fibroplasia in the superficial layer of the tendon did decrease slightly, but tendon cell morphology was that of active fibroblasts. The results support the concept that flexor tendons may show intrinsic fibroplasia when nourished by synovial fluid, while macrophages, mainly of extrinsic origin, contribute to restoration of the tendon surface.

Animals↗
PubMed1980

Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study.

The aim of this investigation was to develop an experimental model for studies on the significance of fibrin deposition for wound healing. Systemic defirbinogenation with Arvin was used to achieve abnormal fibrin deposition in subcutaneously implanted cellulose sponges. The formation of granulation tissue in the sponges was studied histologically. Arvin injections resulted in a rapid decrease in plasma fibrinogen concentration with a concomittant rise in fibrin-degradation products. No change in FXIIIa activity was seen. During defibrinogenation an abnormal fibrin deposition was found in the sponges. The fibrin strands appeared irregular and disrupted. The number of fibroblasts and collagen fibrils was reduced in granulation tissue formed during defibrinogenation. The model used seems to allow controlled studies on the significance of fibrin deposition for wound healing. Defibrinogenation was found to influence granulation tissue formation.

Animals↗
PubMed1980

Flexor tendon specimens in organ cultures.

The healing process of sectioned and subsequently sutured rabbit tendon segments was studied over a period of 3 weeks, using an organ culture technique. In one series, the tendon specimens were exposed to a chemically defined culture medium for nutrition. In two control series, the specimens were kept in the synovial cavity of the knee joint for varying periods of time, before being transferred to the culture medium. The tendons remained viable in the medium. The superficial tendon cells demonstrated the morphological characteristics of fibroblasts, but cellular fibroplasia could not be detected. The two control series subjected to synovia prior to transfer into the culture medium showed superficial repair similar to the findings in previous studies on healing capacity of tendon nourished by synovia. The investigation supports the hypothesis that superficial tendon cells are fibroblasts with a potential for repair and that synovia is an efficient nutrient medium. Thus, the beneficial effects on repair exercised by the tendon sheath function should be utilized in flexor tendon surgery.

Animals↗
PubMed1980

Cell composition of granulation tissue in defibrinogenated rabbits.

The influence of systemic defibrinogenation on cell composition and capillary formation in sponge-induced early granulation tissue was studied in rabbits. The tissue was studied histologically and the content of RNA, DNA and Hb was determined. Inflammatory cells were identified and quantified using histochemical and biochemical techniques. An accumulation of PMN-leucocytes was found after defibrinogenation whereas the amount of fibroblasts and capillaries was reduced.

Afibrinogenemia↗
PubMed1980

Cytochemical study of granulation tissue in zinc treated rats.

The effect of zinc administration on cell composition of early granulation tissue has been studied in rats using histological and cytochemical methods. Granulation tissue was obtained by subcutaneous implantation of polyvinyl sponges. The experimental group was given zinc intramuscularly daily beginning preoperatively. Zinc administration does not change the early inflammatory cell infiltration but results in a more rapid disappearance of polymorphonuclear granulocytes from the granulation tissue. No effect can be seen on the mononuclear cell population. The observations are related to alterations in repair processes following zinc administration.

Acid Phosphatase↗
PubMed1978

Experimental intrinsic healing of flexor tendons based upon synovial fluid nutrition.

The healing process of totally cut and subsequently resutured rabbit flexor tendons kept isolated in the knee joint cavity and free in the synovial fluid was studied by histological and ultrastructural techniques. This experimental model represents a "tissue culture in situ," where the tendon is nourished by diffusion from the synovial fluid only and where no adhesions are formed. Under these conditions there is a proliferation of tendon cells and deposition of collagen resulting in bridging of the suture line. On the basis of these findings, it is assumed that the tendon cells possess an intrinsic potential of repair, provided they obtain a sufficient nutritional supply. In the present experimental model, this nutrition was provided by way of diffusional pathways from the synovial fluid.

Animals↗