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Biomedical subjects

F Reisecker

Publications and source records attributed to F Reisecker.

At least 19 recordsLinked to original sources
PubMed1992

[Modification of blood viscosity and elasticity. Principle therapeutic approach in relation to its pathophysiology].

Exercising a therapeutic influence on the viscoelastic properties of whole blood is a very complex matter. In general, apart from hemodilution, the modification of such factors as erythrocyte aggregation, red cell rigidity or plasma viscosity, all of which may be influenced more or less independently of one another, are possible approaches. The present article discusses the basic possibilities of influencing the viscoelasticity of blood for therapeutic purposes, with attention being paid in particular to the pathogenesis of hyperviscosemia.

Blood Viscosity↗
PubMed1992

Hypervolemic haemodilution and completed stroke: how important is the application time for its effect?

In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group B for 4 hours and group C for 6 hours. Haematocrit (HCT), whole blood viscosity (VI-VB), blood elasticity (EL-VB) and plasma viscosity (VI-PL) were determined before onset of infusion, after 6 and 18 hours subsequently. The values obtained were compared with the onset results. In all groups and parameters after 6 hours there was a significant decrease. After 18 hours group A showed a significant higher value of HCT and increasing trends for VI-VB and EL-VB. In group B after 18 hours a significant decrease of VI-VB could be observed. In group C all values remained significantly below the onset. The results show, that one important haemorheological argument for an effective form of haemodilution should also be a long application time. This might be one of the reasons, why in some studies with hypervolemic haemodilution no positive results could be obtained.

Adult↗
PubMed1992

[A comparative study of the sensory conduction velocity of the sural nerve using surface and needle electrodes].

In 18 healthy persons aged 22-71 years and 17 patients suffering from clinically defined polyneuropathy the NCV of the sural nerve was measured both by antidromic technic recorded by surface electrodes and by orthodromic technique recorded by needle electrodes. Stimulation was done by bipolar surface electrodes in all cases. The skin temperature was warmed up to the minimum of 35 degrees C. The results showed in both groups a highly significant correlation of the NCV measured by antidromic and orthodromic technique. With increasing age the NCV decreased, but this was not significant. In all healthy persons sensory nerve potentials could be recorded with both techniques. In polyneuropathy missing of sensory potentials was higher in patients investigated by the antidromic technique than by orthodromic. For clinical practice measurement of NCV in sural nerve using antidromic technique should be preferred because of its simpler and faster achieving, its lower discomfort for the patient and avoiding risk of infection. However in case of missing nerve potentials, orthodromic investigation using needle electrodes for recording should be added.

Adult↗
PubMed1992

[Effect of naftidrofuryl on viscoelasticity, thrombocyte aggregation and erythrocyte fluidity of blood].

In 30 patients suffering from cerebrovascular disease stage I with atherosclerotic plaques in the carotid's bifurcation the effect of a 7-days application with 400 mg Naftidrofuryl versus NaCl was tested. As parameters viscosity and elasticity of whole blood, plasma viscosity, erythrocytes' and membrane fluidity point, as well as platelet aggregation (spontaneous, ADP-, Epinephrine- and Collagen-induced) were determined before onset, after 4 days and after 8 days. After 8 days treatment with naftidrofuryl there was a significant improvement in viscosity and elasticity of whole blood as well as in erythrocytes' elongation, membrane-fluidity and in the induced test of platelet aggregation.

Aged↗
PubMed1992

Autonomic neuropathies in skin and its incidence in non-insulin-dependent diabetes mellitus.

The autonomic function of nerve fibres was investigated with the newly developed hyperthermal Laser-Doppler-Flowmetry in 45 patients suffering from Non-Insulin-Dependent Diabetes Mellitus (NIDDM). They were divided into 3 groups depending on the duration of NIDDM. Group A contained a duration of 1-3 years, group B 4-5 years and group C 5-6 years. All groups showed a dysfunction of autonomic nerve fibres: in group A there were 4 of 11 patients, in group B 2 of 13 and in group C no patients with values within the normal ranges. So autonomic neuropathies of skin seem to be one of the earliest complications in NIDDM

Adult↗
PubMed1992

[Lack of specificity of single photon emission computerized tomography in dementia--results of a case of progressive paralysis].

In a 53-year old male suffering from paretic neurosyphilis, SPECT-investigations were performed before and after treatment with high doses of Penicillin G. The patient was admitted for disturbances of speech and concentration, memory disorder and tonic-clonic seizures. Mental examination showed a mild dysphoria and irritability in mood, but no disturbance of orientation, no euphoria or expansive delusions, and no paranoia. Mini-Mental-State examination was within the normal range (28 points); no abnormalities were found on neurologic examination, and CT and MRI investigations showed normal findings. The diagnosis was verified by CSF-examination (pleocytosis, elevated protein, positive Lues reactions). SPECT investigation with Tc 99m HMPAO (20 mCi, single-head rotating camera) revealed a pronounced bilateral parieto-temporal uptake deficiency as observed in patients with dementia of Alzheimer's type. After 18 months the clinical symptoms had remitted, and laboratory findings were improved. On the other hand, the bilateral parieto-temporal uptake deficiency in SPECT remained unchanged. Possible causes of these findings are discussed in relation to neuropathologic findings. It can be concluded that bilateral parieto-temporal uptake deficiency in SPECT is a nonspecific finding and that there is no correlation between clinical improvement and SPECT pattern in paretic neurosyphilis.

Dementia↗
PubMed1991

Long latency EMG responses in early diagnosis of Huntington's chorea.

In healthy subjects, 2 EMG responses of the thenar muscles can be distinguished, elicited by electrical stimulation of the median nerve during an isometric contraction: an early spinal response (M1) and a long latency response (LLR) (M2); earlier studies have shown that in patients with Huntington's chorea (HC) this late EMG response is missing. LLR were studied in the nine subjects at risk out of three families with definite HC. In 6 of them, LLR was clearly asymmetrical or absent on one or both sides, while normal LLRs were seen in the rest of the subjects studied; LLR abnormalities found in clinically free members of HC families may assist in early diagnosis of individuals who may later develop symptoms and may help in genetic counselling.

Adult↗
PubMed1991

Clinical and electrodiagnostic findings, nerve biopsy and blood group markers in a family with hereditary neuropathy with liability to pressure palsies.

Clinical, electrophysiologic and biopsy findings as well as studies of blood group markers in a family with hereditary neuropathy with liability to pressure palsies (HNPP) are reported. There was an autosomal dominant trait without genetic linkage between the HNPP gene and blood group markers controlled by chromosome 1. Reduced motor and sensory nerve conduction velocity was found in clinically affected and unaffected nerves. Characteristic morphological changes in sural nerve biopsy including tomaculous swelling were present.

Adolescent↗
PubMed1991

[Kinetic effects of 6% hydroxyethyl starch 200.000/0.6-0.66 in hypervolemic hemodilution].

An open study was carried out in order to examine therapeutic effectivity of repeated administration of 6% hydroxyethyl starch 200.000/0.60-0.66 (HES). 10 patients aged 63 to 77 years with peripheral arterial occlusive disease Stage II b were given 500 ml Elohaest as a hypervolemic hemodilution for 12 days. Fasting levels of hydroxyethyl starch (HES) in serum, hematocrit, and serum-alpha-amylase were measured. During the first 4 treatment days, HES levels and serum-alpha-amylase increased in a significant manner; then it fluctuated towards a plateau without significant differences. The hematocrit decreased significantly from the beginning to the end of therapy. So it was possible to show, that during repeated application with the chosen dosage of 6% HAES 200.000/0.6-0.66 there is no dangerous cumulation of HAES.

Aged↗
PubMed1991

[Hypervolemic hemodilution with medium molecular-weight hydroxyethyl starch: effect of duration of administration on viscoelasticity of blood in IIa and IIb peripheral arterial occlusive disease].

45 consecutive patients suffering from peripheral arterial occlusive disease (PAOD) stage IIa and b were integrated in a study about the effect of hemorheological parameters due to different application times. The patients were divided into 3 subgroups with different application times: group A received the infusion during 2, group B during 4, and group C during 6 hours. The used substance was 500 ml 6% HES 200,000/0.6-0.66. Except elasticity of group A all hemorheological parameters from group A to group C show a decrease after 6 hours, the trend to the same phenomenon could be observed after 24 hours in group B and C, while group A except plasma viscosity showed even a trend to increasing values compared to onset. As a conclusion of these results, long-time application should be preferred.

Adult↗
PubMed1991

[Treatment of acute manifestation of hemichorea with aspirin. A case report].

A patient is described with a history of coronary artery disease and diabetes showing unilateral continuous jerking limb movements immediately after general anaesthesia. Carotid territory hypoperfusion is assumed to be the pathogenetic factor of these involuntary limb movements. 2 days after administration of 1000 mg Aspirin these movements ceased, supporting this trial prior to invasive surgical procedures especially in high risk patients.

Aged↗
PubMed1991

[Gallopamil and changes of adenosine diphosphate- and collagen-induced thrombocyte aggregation].

In blood samples of 12 healthy volunteers (5 female, 7 male) the influence of Gallopamil (Procorum, CAS 16662-47-8) on the adenosine-diphosphate- (ADP-) and collagen-induced platelet aggregation was studied. Measurements in platelet rich plasma after induction with 1 mumol ADP and 0.5 microgramml collagen with gallopamil were performed. After incubation mit 250 mumol gallopamil a second test was carried out. The parameters were compared with the U-test. After application of 250 mumol gallopamil a significant reduction of ADP- and collagen-induced platelet aggregation could be observed. This is a sign for a protective effect of gallopamil in atherosclerotic disorders due to its calcium-channel blocking property.

Adenosine Diphosphate↗
PubMed1991

[Botulinum toxin A in therapy of craniocervical dystonias and hemifacial spasm].

34 patients with focal dystonias (13 with essential blepharospasm, 3 with Meige's syndrome, 2 with hemifacial spasm, 16 with spasmodic torticollis) were treated with botulinum type A toxin. 4 ng of botulinum type A toxin per eye were applied in the M. orbicularis oculi as first injection in the 18 patients without spasmodic torticollis. The 16 patients with idiopathic spasmodic torticollis received 10 ng botulinum toxin A in the contralateral M. sternocleidomastoideus as well as in the ipsilateral M. splenius capitis as first injection. The effect was monitored for a time period of at least 6 weeks by two subjective rating scores, a visual functional score and a global clinical impression score. Patients with blepharospasm showed a distinct improvement already after 4 days which lasted for 6 weeks. 75% of the patients with spasmodic torticollis experienced a moderate to distinct improvement after 4 days which remained stable for 6 weeks. A second injection was performed in 15 (7 blepharospasm, 8 spasmodic torticollis) patients 9-11 weeks later with a similar success. All observed side effects (weakness; stiffness of local muscles; feeling of dryness of eyes, unilateral ptosis) were mild and of transient nature. We suggest therefore botulinum type A toxin as treatment of first choice in focal dystonias.

Adult↗
PubMed1991

[Effect of metoprolol on microcirculation and blood viscoelasticity].

In 40 patients microcirculation of skin as well as viscoelasticity of blood and plasma were investigated. 20 of them suffered from essential hypertension (group A) and were treated with metoprolol with a dosage of 50 to 200 mg per day. The rest of 20 subjects were controls (group B). In the group treated with metoprolol the values for blood viscosity were decreased in a significant manner, while skin microcirculation, blood elasticity and plasma viscosity did not show a significant difference. The results demonstrate that metoprolol is not only possible as medication in ischemic disease, but this substance can have a benefit in this indication because of its hemorheological effect.

Blood Flow Velocity↗
PubMed1991

[Modifications in erythrocyte elongation in blood samples of test subjects following gallopamil administration].

In 12 blood samples of healthy non-smokers younger than 40 years the erythrocytes-elongation was studied after Gallopamil-incubation, to obtain data for a possible rheological effect of this substance. For incubation dosages of 20, 50 and 100 micrograms/ml were used. After incubation with 50 and 100 micrograms/ml the elongation index of red blood cells increased in a significant manner. The results show, that Gallopamil does not only have a effect for vasodilatation but also for hemorheological parameters.

Adult↗