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Biomedical subjects

F Reisecker

Publications and source records attributed to F Reisecker.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Volume replacement with 2 equivalent molecular weight dextrans: effect on erythrocyte elongation in vitro].

The influence of 2 dextranes with the identical molecular weight of 70,000 Dalton for erythrocytes' elongation was investigated in-vitro in 12 healthy male subjects. An increasing dosage between 0.5 and 10 mg/ml Dextran (trade name: Dextran 70 "Ebewe") and Dextran B (weight-equivalent) was added and the elongation index of erythrocytes at shear-rate 50/sec was determined under fluid conditions. Dextran B showed a stronger reduction of elongation index than Dextran A with an elevation of difference up to the highest dosage. The results show that although the molecular weight is identical, differences in hemorheological properties could observed. This should be taken into consideration for volume substitution therapy.

Adult↗
PubMed1990

[The treatment of blepharospasm with botulinum toxin A].

12 patients suffering from essential blepharospasm were treated by injection of 4 ng botulinum toxin A into the Musculus orbicularis oculi of each eye. The effect was followed up over a period of 6 weeks by means of a subjective rating scale, a visual function score and a score for the overall clinical impression. After 4 days an improvement was observed in all patients and it was still present after 6 weeks. After a time interval of 12 weeks reinjection was performed in 8 cases with half the initial dose, since the beneficial effect had decreased to under 50%. Follow-up showed an impressive response to reinjection of botulinum toxin A, which remained undiminished still after 6 weeks. No serious side effects were observed. Hence, this form of therapy appears to be an effective alternative to all other therapeutic measures in this disease.

Adult↗
PubMed1990

[Erythrocyte elongation with 10% dextran 40,000: comparison of 2 substances].

A dosage-effect-study with two 10% dextrans 40,000 was carried out in 12 venous blood samples of healthy men aged from 21 to 45 years. Dextran A (trade name: Dextran 40,000 "Ebewe") and Dextran B (trade name: "Rheomacrodex") were added in dosages of 0.5 to 10 mg/ml whole blood and the elongation-index of erythrocytes at shearrate 50/sec was determined. From 1 mg up to 10 mg/ml the elongation-index in Dextran B showed a stronger decrease than in Dextran A. Under the highest dosage the difference was about 20%. So it was possible to show that in spite of identical molecular weight there are different effects on deformability of erythrocytes. This should be taken into account for parenteral treatment.

Adult↗
PubMed1990

[Effect of dextran 40,000 on collagen-induced platelet aggregation].

In blood samples of 12 healthy male volunteers under 50 years old the collagen induced platelet aggregation and the influence of a new 10% dextran 40.000 (Dextran Ebewe) was studied. Dextran was added to the samples with a concentration from 10 microliters up to 50 microliters/ml blood. In a concentration of 20 microliters/ml blood a significantly reduced collagen induced platelet aggregation was be observed. Higher dosages did not differ in a significant manner from this effect.

Adult↗
PubMed1989

[Single-photon emission-computed tomography in the differential diagnosis of dementia].

To assess the value of single photon emission computed tomography (SPECT) in the differential diagnosis of dementia SPECT and conventional computed tomography were performed in 77 patients (50 men, 27 women, mean age 59 [28-90] years) with dementia diagnosed by a battery of psychometric tests. In 13 out of 15 patients with dementia of Alzheimer type SPECT showed a typical Alzheimer pattern (bilateral parietotemporal perfusion defects). Both patients with dementia of Pick type had definite decreases in frontal perfusion. All 21 patients with dementia due to Huntington's chorea showed a typical pattern with absent perfusion of the head of the caudate nucleus, although in three of them conventional computed tomography didn't demonstrate complete atrophy of this structure. Out of 23 patients with multi-infarct dementia there were 17 with focal uptake deficits at various sites, while six displayed an Alzheimer pattern. In Korsakoff's syndrome (n = 11), Down's syndrome (n = 1), Fahr's syndrome (n = 2), senile chorea (n = 1) and HIV encephalopathy (n = 1) no typical distribution patterns were noted. Single photon emission computed tomography can make a contribution to the diagnosis and classification of primary degenerative dementias and can be used to differentiate them from other forms of dementia.

AIDS Dementia Complex↗
PubMed1989

[Brain abscess. Prognostic factors].

Thirty-eight cases of cerebral abscess were analysed retrospectively for any factors that might influence outcome. Using the "Glasgow outcome score", age, history, level of consciousness, as well as various computed tomography findings (cisternal swelling, compression of the ventricular system, degree of oedema and size of abscess) were considered for their prognostic value. It was found that age over 40 years and clouded consciousness exerted a statistically significant unfavourable effect (P less than 0.05). Outcome was also unfavourable in half the patients with multiple abscesses, but the number of cases (six) was too small to be statistically significant. All other variables had no statistically significant influence on prognosis.

Adolescent↗
PubMed1989

A new measuring design for autonomic dysfunction of skin in neuropathies: hyperthermal laser-Doppler flowmetry.

Twenty patients suffering from diabetic neuropathy, 20 patients suffering from alcoholic neuropathy and 20 healthy volunteers within the same age range were studied for the stimulability of microcirculation with a new measuring design. A laser method (laser-Doppler flowmetry) was used to evaluate the increase of the microvascular blood flow of the skin during the hyperthermal phase. It evaluated the degree of increase of microcirculatory blood flow as well as the time from the beginning of hyperthermy to the onset of change in perfusion (the hyperthermal perfusion latency). This was significantly prolonged in both neuropathy groups; the increase of the microvascular blood flow in the diabetic neuropathies was significantly lower than found in alcoholic neuropathies and in healthy volunteers.

Aged↗
PubMed1988

[Chronic subdural hematoma in aged patients. Diagnostic problems].

The history, clinical features, laboratory tests and admission circumstances were analysed retrospectively in 14 patients, aged 60 to 87 years, who were found to have a chronic subdural haematoma. Typical clinical features consisted of dominant psychiatric disorders, slow progression and frequently only traces of neurological signs. In only four patients was headache the initial symptom. Delay in diagnosis and treatment worsened the prognosis. Several factors account for the nonspecific signs and symptoms: diffuse cerebral atrophy, dementia of a degenerative or vascular nature, and cerebral decompensation. Computed tomography immediately after a trauma may be negative.

Accidental Falls↗
PubMed1988

Diagnostic value of different electrophysiologic tests in cervical disk prolapse.

We evaluated 24 patients with radiologically verified cervical disk prolapse. EMG abnormalities appeared in 67% of cases studied; dermatomal somatosensory evoked potentials revealed 85% abnormal findings on the affected side, but also revealed abnormalities in adjacent segments. In 38%, F responses were abnormal. We found electrodiagnostic abnormalities at levels without a disk prolapse, probably due to degenerative spondylopathic changes and beginning consecutive vascular compromise.

Adult↗
PubMed1988

[Early somatosensory evoked potentials in ischemic cerebrovascular diseases--I: Methodology, patients, normal group and review of the literature].

Somatosensory evoked potentials (SEP) were examined in 140 patients suffering from cerebro-vascular ischemic disease. Patients were classified in 1. asymptomatic stenosis/occlusion, 2. complicated migraine, 3. transient ischemic attacks (TIA), 4. reversible ischemic neurologic deficit (RIND), 5. completed stroke and 6. Multiinfarct-dementia. Normal SEP values were obtained from 26 age-correlated normal persons without a history of neurologic or psychiatric disease. The findings were correlated to clinical data, EEG, Single-Photon Emission and Transmission Computertomography (SPECT, TCT). SEP were done by stimulation of the median nerve. We evaluated central conduction time (CCT), amplitude ratio (AR) and number of phases (PHAS) of cortical potentials within 50 ms. Also quotient of amplitude ratio left stimulation side to right stimulation side (AR l/r) was calculated. EEG were recorded by 19 electrodes according to the 10-20 scheme, focal signs and diffuse changes were evaluated. In TCT the location of hypodense lesions was evaluated. SPECT was performed by application of J123 IMP and Tc99 HMPAO as a tracer. Focal decrease of tracer uptake compared to the compartment was evaluated. Results of animal experiments and clinical studies are discussed in respect of patients and methods.

Adult↗
PubMed1988

[Early somatosensory evoked potentials in ischemic diseases--II: Normal values and findings in asymptomatic vascular stenoses/occlusions, complicated migraine, transitory ischemic attacks, reversible ischemic neurologic deficit, complete stroke and multi-infarct dementia].

Somatosensory evoked potentials (SEP) were investigated in 140 patients suffering from cerebro-vascular ischemic disease (CVD). Data were compared to age-correlated normal persons (n = 26; male 16, mean age 55.6 years SD 10.9). Patients with asymptomatic vascular diseases (n = 10; male 7, mean age 63.8 years SD 10.4) showed bilateral prolonged CCT (left side p less than 0.05). Patients with TIA (n = 44; male 21, 58.3 years SD 12.3), complicated migraine (n = 3, all female, 24, 40, 63 years) and RIND (n = 17; male 10, 56.5 years SD 16.8) showed no abnormalities of CCT and AR as compared to normals. Abnormalities of PHAS were only seen in patients with RIND of the right carotic supply. In patients suffering from completed stroke (n = 40; male 29, mean age 56.9 years SD 14.4) bilateral prolongation of CCT was seen in those with ischemia of the right carotic supply; those with ischemia of the left carotic supply showed a significant asymmetry of CCT and deviation of AR l/r. In two patients with infarction of the pons an increase of CCT and decrease of AR at the side of the lesion was found. Patients with MID (n = 27; male 20, 69.7 years SD 10.3) showed significant bilateral prolongation of CCT, increase of AR (at the side of stimulation) and deviation of AR l/r (1.63).

Adult↗
PubMed1988

[Early somatosensory evoked potentials in cerebrovascular ischemic diseases. III. Correlations with age, sex, clinical data, EEG, emission and transmission computed tomography].

Short latency SEP were investigated in 140 patients suffering from various cerebrovascular ischemic disease (CVD). CCT,AR and number of cortical phases of each stimulation side, as well as AR left to right side (AR l/r) were correlated to patient's age and sex, to diagnosis and vascular supply, to clinical symptoms, duration between stroke and investigation, SPECT, TCT and EEG. Significant correlations were found between CCT and diagnosis, vascular supply, clinical symptoms, duration, SPECT and TCT findings. CCT was prolonged in patients with completed stroke, MID, ischemia of the A.C.M., sensomotor hemiparesis or monoparesis of the upper extremity and lesions in SPECT and TCT located within thalamus and/or postcentral gyrus. Decreased perfusion in SPECT was only of statistical significance when it was combined with clinical symptoms and/or lesions in TCT. Significant correlations were found between AR l/r and all variables except age and sex. Differences in sub-groups corresponded to those found for the CCT. AR was lower at the affected side. Deviations of AR were also found in patients with focal lesions both in the EEG and in the TCT. Significant correlations were found between number of phases, clinical findings and SPECT, but no correlation was seen to TCT. Patients with CVD showed significant abnormalities of CCT and AR only in cases presenting neurological deficit and structural lesion in TCT. The abnormalities were more prominent in patients with an interval stroke-investigation over one year. No abnormalities were seen in patients with reversible symptomatology investigated after cessation of symptoms. A direct correlation may be suspected between number of phases and tracer uptake in SPECT.

Adult↗