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Biomedical subjects

F Roux

Publications and source records attributed to F Roux.

At least 37 records · Page 2Linked to original sources
PubMed1979

Relevance of antibiotics in the treatment of brain abscesses. Report of a case with eight simultaneous brain abscesses treated and cured medically.

A case of eight simultaneous brain abscesses in the right cerebral hemisphere, treated medically after puncture of two of them, is reported. Antibiotics and hypertonic mannitol and, after seven days, dexamethasone were sufficient to cure these lesions. CT scan was of primary importance to follow the evolution under treatment. To get the best efficiency from antibiotics, identification of the microorganism and assessment of its resistance to antibiotics are necessary. It is suggested that in certain conditions medical therapy might be sufficient to treat cerebral abscess, after simple puncture to isolate the infecting agent. Corticosteroids should be avoided in the acute phase because they prevent antibiotics from penetrating the abscesses.

Adult↗
PubMed1978

[Preliminary results of a new radioimmunoassay for thyroxine binding globulin (T.B.G.) (author's transl)].

A radioimmunoassay for the accurate measurement of T.B.G., developed by Crouzat-Reynes, was used to perform T.B.G. concentration in sera of euthyroid subjects in different clinical situations, in hypothyroid and hyperthyroid patients. In normal control, the T.B.G. concentration was not different from men and women, from young and old subjects (m = 21,1; sigma = 3,9). On the other hand, in women either pregnant (m = 51,2; sigma = 18,1) or receiving oral contraception (m = 30,1; sigma = 5,7), the T.B.G. levels were significantly higher than euthyro subjects. Cirrhosis of the liver and liver carcinoma were without apparent effect on T.B.G. levels because it was a too few number of patients and the group was too heterogeneous. In the group of hypothyroid (m = 25,9; sigma = 6,5) and hyperthyroid (m = 21,1; sigma = 5,5) patients, the T.B.G. serum concentrations were not significantly different from normal. The ratio T4/T.B.G., as I.T.L. (T4 X T3 uptake) permit to bring back in normal range T4 levels changed by extrathyroidal process; however, this ratio seems to us to be less interesting than standard I.T.L. The T.B.G. assay has not to be considered only as a substitution of T3 uptake because they do not study the same parameters.

Adolescent↗
PubMed1978

Effect of lindane on mouse peritoneal macrophages.

Among the effects of lindane in vitro on mouse peritoneal macrophages, the inhibition of uridine incorporation correlated with the reduction of intracellular uridine pool was the most pronounced. This decrease was significant at a concentration of 10(-4) M after 12 h of treatment. The rate of leucine incorporation did not show any change during the 24-h study. The decrease in pinocytosis rate and acid phosphatase activity occurred with lindane concentrations superior to 10(-4) M or after treatment of more than 12 h. Pinocytosis inhibition may have been associated with cytoplasm vacuolation. The high lindane doses necessary to inhibit some of these macrophage functions belong to the range of concentrations exerting biological effects unrelated to its insecticidal effects, which involves stereochemical specificity. The effects of lindane on mouse peritoneal macrophages, similar to the effects of anesthetics, seemed to be determined by its lipophilicity, which may exert disordering effects in the lipid domains of the membrane. Such perturbations could involve changes in the conformation of transport sites as well as in the integrity of the membrane and cytoskeleton structures which govern the processes of pinocytosis and lysosomal fusion.

Acid Phosphatase↗
PubMed1978

[Toxic pathology of the hepatocyte in histiotype culture. I. The experimental model. Ultrastructural and cytochemical study].

Principle of the method. Description of the techniques used to obtain the cultures, light and electron microscopic study, biochemical determination of proteins, of DNA, of the incorporation of H3-thymidine, of total and lysosomal acid phosphatase activity. Detailed description of hepatocytes developed in unicellular layer: shape and distribution of the cells, junctions, cellular apparatuses and organelles, cytoplasmic inclusions. Comparison of the hepatocyte in vitro and in vivo. The most obvious differences are related to experimental conditions of geometry and nutrition. Particular note should be taken of the microvillous appendices of the free surface and the underlying explasmic layer. Specific physiological activities are evident, including glycogenogenesis. Discussion of multiplication, growth and cellular differentiation phenomena. Vitality tests. In culture, there may develop a tendency to hypertrophy of the mitochondria, of the dictyosomes, to hyperplasia of the granular or smooth endoplasmic reticulum and above all to increased autophagia.

Acid Phosphatase↗
PubMed1978

[beta2-Microglobulin and carcino-embryonic antigen in bronchogenic carcinoma (author's transl)].

In a series of 52 patients with bronchogenic carcinoma serum levels of beta2-microglobulin (beta2m) and carcino-embryonic antigen (CEA) were studied. No correlation was found between the increase of beta2m (greater than 3,2 mg/l) and CEA (greater than 40 ng/l). High levels were found in 10 % of cases for CEA and in 30% of cases for beta2m. The follow-up of serum levels of beta2m and CEA was studied during the evolution of the disease through monthly assays. Upon 15 cases followed, the same dissociation between beta2m and CEA was observed.

Beta-Globulins↗
PubMed1978

[beta2-Microglobulin and pulmonary tuberculosis (author's transl)].

Serum beta2-microglobulin levels, determined in 29 healthy adults were found to be 1,3 mg/l with an upper confidence limit (95%) of 2,0 mg/ml. In contrast, serum values in 101 patients with pulmonary tuberculosis were 2,1 mg/l with an upper confidence limit of 3,2 mg/l. The latter value is therefore to be taken into consideration if serum beta2m is to be used for discriminating between lung carcinoma and other pulmonary diseases.

Beta-Globulins↗
PubMed1978

[Toxic pathology of the hepatocyte in histiotype culture. II--Effects of an organic chlorine compound: lindane. Effect of a foreign metabolizable substance and toxic effect].

Lindane or HCH is gamma-hexachlorocyclohexane, still used as an agricultural insecticide. Tests were carried out using primary cultures of chicken embryo hepatocytes at the 11th day of incubation, for a fixed period of 40 hours, using different concentrations of the substance. From 0.5 to 10 mumol/l, acid phosphatase fell significantly, without any other consequences being observed. From 25 to 50 mumol/l, there was a tendency to hypertrophy of the mitochondria, to hyperplasia of the granular and smooth endoplasmic reticulum, and of the Golgi system. Growth was unchanged and acid phosphatase decreased. From 75 to 125 mumol/l, these changes were accompanied by signs of cellular damage and there was marked autophagia. Growth was reduced and acid phosphatase greatly decreased. From 150 to 175 mumol/l, the lesions were markedly polymorphous and some indicative of impending cytolysis, in particular spiral tearing of the hyaloplasm. Growth was markedly impaired, whilst there was a paradoxal increase in acid phosphatase. In increasing concentration, L first had the effect of a metabolisable foreign substance, of the "phenobarbital" type, then a definite toxic action. Sensitivity of the individual hepatocytes differed.

Animals↗
PubMed1977

[Analysis of one thousand liver scans carried out using technetium phytate (author's transl)].

One thousand liver scans were carried out using technetium phytate. This soluble compound is transformed in the circulating blood into a colloid by chelation of serum calcium, thereby forming a macromolecular phytate of calcium and technetium. The presenting symptoms are compared with the isotopic findings. This microcolloid has the advantages common to all technetium tracers and, in addition, is easy to prepare and has the advantage of a distribution between the liver, spleen and bone of the same type as that seen with colloidal gold 198 without the dosimetric problems associated with the latter. Although it has a level of hepatic fixation which is less than that of certain sulphide complexes of technetium, the authors feel that it appears to provide a better relfection of the colloidopexic function of the liver.

Adult↗
PubMed1976

[Early isotopic synoviorthesis during rheumatoid polyarthritis (RP)].

The authors report the results of 1258 chemical synovectomies carried out in subjects with rheumatoid polyarthritis on joints at Steinbrocker stage I and of 470 chemical synovectomies carried out during the first year of evolution of rheumatoid polyarthritis. Comparison with the results of chemical synovectomy carried out later demonstrate the superiority of early chemical synovectomy.

Arthritis, Rheumatoid↗
PubMed1975

[14 cases of constrictive endocardial fibrosis (or endomyocardial fibrosis].

Constrictive endocardial fibrosis (CEF) or endomyocardial fibrosis (EMF) was studied on 14 files of this rather frequent disease in Ivory Coast. On the basis of the data derived from angiocardiography, catheterization and mechanograms, the clinical signs are interpreted better. Thus one is able to describe with accuracy some clinical forms, the commonest of which being a right heart restriction combined with left-sided signs. It seems important underline how useful the external pulse recordings might be useful for the diagnosis in view of their analogy with the pressure curves. In this disease with a severe course, bold surgical treatments provide some hope. On the contrary, its aetiology remains mysterious. Our best landmark being the link of CEP with tropical ecology, and in particular, in our cases, with the warm and damp forest ecology of some areas.

Adolescent↗