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Biomedical subjects

F S Jorgensen

Publications and source records attributed to F S Jorgensen.

At least 19 recordsLinked to original sources
PubMed2003

Treatment of severe fetal chylothorax associated with pronounced hydrops with intrapleural injection of OK-432.

We describe a case of a 25-week fetus with severe bilateral pleural effusion, marked ascites, skin edema, an anterior thick (hydropic) placenta and polyhydramnios in which the most probable diagnosis was congenital chylothorax. Treatment with a pleuroamniotic shunt was planned, however the location of the fetus just below the anterior placenta made the placement of the shunt too dangerous. We therefore decided to use intrapleural injection of OK-432. From week 29, the lungs looked normal, the pleural effusion had resolved and the thoracic circumference was within normal limits. The severe ascites persisted throughout the pregnancy and a total volume of 3680 mL was removed on several occasions. A Cesarean section was performed at 38 weeks and a normal male was delivered. Continuous positive airway pressure was needed on the first 4 days but after a week the situation was stable. On day 8, an X-ray showed normally developed lungs. OK-432 appears to have prevented pulmonary hypoplasia in our patient.

Adult↗
PubMed1977

Correlation between rises of gonadotrophins and rises of sex steroids during clomiphene test in men.

Serum FSH, LH and testosterone and urinary excretion of androsterone, aetiocholanolone, dehydroepiandrosterone and total oestrogens were measured in normal and oligospermic men before and after clomiphene stimulation. Responses in all parameters were highly variably from one individual to another and this great variation formed the basis for investigating the correlations between responses. There was no correlation between increase of FSH and LH or increase of LH and steroids. Also there was no correlation between rises of FSH and rises of androgens. But a significant correlation existed between rises of FSH and rises of oestrogens. This confirms that one action of FSH is to stimulate production of testicular oestrogens which presumably takes place in the Sertoli cells.

Adolescent↗
PubMed1976

Enzyme induction by oral testosterone.

Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half-life had decreased significantly from 8.0 +/- 2.7 to 5.7 +/- 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty-first day of testosterone ingestion than on the first day. Serum albumin, bilirubin, prothrombin, alanine-amino-transferase, and alkaline phosphatases were unchanged during the experiment. It is concluded that oral testosterone treatment induces the hepatic drug-metabolizing system including that of testosterone.

Administration, Oral↗
PubMed1976

Rise in dehydroepiandrosterone and oestrogens during clomiphene administration in normal men.

Serum concentrations of LH, FSH and testosterone, and urinary excretion of individual 17-ketosteroids, oestrogenic substances and free cortisol was investigated in 12 normal men after a daily administration of 50 mg clomiphene citrate for 14 days. A significant increase in the serum concentrations of LH, FSH and testosterone was seen after 8 days with a further increase when measured a week later. The percentual increase in urinary excretion of oestrogens and dehydroepiandrosterone was of the same order as the increase in serum testosterone concentrations whereas the increase in androsterone and a aetiocholanolone was significantly lower. The excretion of free cortisol was unaltered. The study that measurements of oestrogens in the urine might be used as a parameter of the stimulatory effect of clomiphene on the hypothalamic - pituitary - gonadal axis in man. In addition, of the results support the hypothesis of an independent effect of clomiphene on adrenal steroidogenesis, not related to the production of glucocorticoids.

17-Ketosteroids↗
PubMed1976

Urinary cyclic AMP. Relation to albumin-corrected serum calcium in healthy persons and patients with primary hyperparathyroidism.

In 21 healthy volunteers, mean excretion of cyclic adenosine 3',5' monophosphate (cAMP) in urine was 4.2 +/- 1.0 (S.D.) mumol cAMP/24 hours, 3.0 +/- 1.2 mumol/g creatinine and 3.8 +/- 1.2 mumol/24 hours/100 ml/min renal clearance of creatinine (CCr). An inverse correlation exists between the excretion of cAMP and serum calcium corrected for variations in serum albumin, most clearly demonstrated when cAMP is expressed as mumol/24 hours/100 ml/min of CCr (r=-0.630, p less than 0.01). In 21 patients with operatively verified hyperparathyroidism, the mean urinary excretion of cAMP/24 hours was 5.0 +/- 1.9 mumol uncorrected, 4.8 +/- 1.8 mumol/g creatinine and 6.6 +/- 2.1 mumol/100 ml/min of CCr. The latter two of these parameters differ significantly from the normal group (p less than 0.001), but conceal the fact that many patients with hyperparathyroidism excrete normal amounts of cAMP in the urine, independent of the mode of calculation. However, when cAMP is correlated to albumin-corrected serum calcium, this overlap between hyperparathyroidism and normality disappears completely. The results support the concept that cAMP excretion is influenced to a considerable degree by the biological activity of circulating parathyroid hormone. They also indicate that the simultaneous measurement of cAMP in urine and albumin-corrected calcium in serum is a useful aid in distinguishing hyperparathyroidism from the state of normality.

Adolescent↗
PubMed1975

LH and FSH in serum after intramuscular administration of LH/FSH-releasing hormone in normal and hypogonadal men.

The increase in serum concentrations of LH and FSH after intramuscular administration of LH/FSH-RH was investigated in normal and hypogonadotrophic hypogonadal males. LH and FSH were measured by specific radio-immunoassays. To evaluate the appropriate dose of LH/FSH-RH for intramuscular administration different doses were administered and with 200 mu g an increase in LH and FSH was found comparable to the results obtained by other investigators using intravenous administration. After the initial studies a simple test including two determinations before LH/FSH-RH administration and one 60 min and 120 min after administration was developed and used in all cases. In 12 normal males a significant increase in the serum concentration of both LH and FSH was found averaging 381% and 148% respectively 60 min after 200 mu g LH/FSH-RH with a slight decrease in LH but not in FSH after 120 min. A positive response similar to that in normal men was observed in 11 hypogonadotrophic hypogonadal patients presenting different clinical pictures. This indicates that in all these patients the hypogonadotrophic state was due to a hypothalamic defect and not to a hypophyseal disorder.

17-Ketosteroids↗
PubMed1975

The urinary excretion and serum concentration of calcium, magnesium, sodium and phosphate in male patients with recurring renal stone formation.

Only about 20% of renal stone cases have an unquestionable cause such as hyperparathyroidism, renal tubular acidosis etc. explaining their stone formation. About 20-40% are believed to result from idiopathic hypercalciuria. The purpose of the present investigation was to study the renal excretion of calcium, magnesium, sodium and phosphate in 47 consecutive men with recurring renal stone formation without a demonstrable underlining metabolic disease and, for comparison, 43 normal men. The results are related to previous hypotheses on renal stone formation. No difference in urinary calcium (either concentration or excretion) per day is found between the two groups. Consequently the concept of idiopathic hypercalciuria is questioned. The Mg/Ca ratio in urine is found lower in the stone patients than in the controls, suggesting that the Mg/Ca ratio might be of importance in stone formation.

Adult↗