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PubMed · 947655

Enzyme induction by oral testosterone.

S G Johnson·J P Kampmann·E P Bennett·F S Jorgensen
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Abstract

Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half-life had decreased significantly from 8.0 +/- 2.7 to 5.7 +/- 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty-first day of testosterone ingestion than on the first day. Serum albumin, bilirubin, prothrombin, alanine-amino-transferase, and alkaline phosphatases were unchanged during the experiment. It is concluded that oral testosterone treatment induces the hepatic drug-metabolizing system including that of testosterone.

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Administration, OralAdultAntipyrineDepression, ChemicalEnzyme InductionHalf-LifeHumansLiver Function TestsMaleTestosteroneTime FactorsAndrogensBiologyClinical ResearchEndocrine SystemEnzymesEnzymes And Enzyme InhibitorsHepatic EffectsHormonesHuman VolunteersMetabolic EffectsPhysiologyResearch MethodologySteroid Metabolic EffectsTestosterone--administraction and dosageTestosterone--analysisTestosterone--side effectsJournal Article

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S G Johnson, J P Kampmann, E P Bennett, F S Jorgensen. 1976. Enzyme induction by oral testosterone.. https://doi.org/10.1002/cpt1976202233

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