Biomedical subjects
F S Vogel
Publications and source records attributed to F S Vogel.
Brain study in balloon-borne monkeys exposed to cosmic rays.
Explore the source record for details and available documents.
Intrinsic ribonucleic acid synthesis in mitochondria of Agaricus campestris underscoring the probability of an extra-nuclear genetic system.
Explore the source record for details and available documents.
An intramitochondrial polypeptide with strong chelating properties for copper: an agent that monitors cytotoxicity.
Explore the source record for details and available documents.
Structural and functional characteristics of deoxyribonucleic acid-rich mitochondria of the common meadow mushroom, Agaricus campestris. I. Intracellular environment.
Explore the source record for details and available documents.
Structural and functional characteristics of deoxyribonucleic acid-rich mitochondria of the common meadow mushroom, Agaricus campestris. II. Extracellular cultures.
Explore the source record for details and available documents.
Granulomatous angiitis. An unusual etiology of stroke.
A 43-year-old man, who died five months after the onset of left-sided sensory deficit, had angiographical and pathological evidence of an angiitis confined largely to the distribution of the right middle cerebral artery. Histological examination identified this process to be intracranial noninfectious granulomatous angiitis. Although certain clinical and pathological features of this disorder overlap with other vasculitides which effect the central nervous system, the disease nevertheless retains sufficient individuality to warrant status as an entity, and should be considered in the differential diagnosis in adults with lesions which produce focal neurological deficits and signs of increased intracranial pressure. The definitive answer regarding an infectious etiology will come only from detailed culture studies of the affected vessels.
Neoplasms of the anterior pituitary.
Explore the source record for details and available documents.
Topographic relationship between neurofibrillary change and acetylcholinesterase rich neurons in the upper brain stem of patients with senile dementia of the Alzheimer's type and Down's syndrome.
In order to establish the topographical relationship between neurofibrillary change and the distribution of cholinergic neurons, the upper brain stems were studied from nine cases of senile dementia of the Alzheimer's type (SDAT). For each case, the distribution of the neurofibrillary changes was recorded and compared with the distribution in five control patients of acetylcholinesterase-rich neurons as determined by enzyme histochemistry. The numbers and distribution of neurons with neurofibrillary change were also studied in five age-matched controls and in three individuals with Down's syndrome. The results indicate that, in contrast to that in control patients, the upper brain stem is heavily involved by neurofibrillary change in SDAT. Correlation of the distribution of neurofibrillary tangles in SDAT patients with the localization of acetylcholinesterase-rich neurons suggests that most of the cholinergic nuclei in the upper brain stem are affected in SDAT, but are not exclusively or predominantly involved. Most neurofibrillary tangles were found in noncholinergic nuclei such as the raphe nuclei and the locus ceruleus. The individuals with Down's syndrome showed a heavy involvement in the older cases, thus reinforcing the significance of Down's syndrome in defining the evolution of pathologic changes in Alzheimer's disease or SDAT.
Meadow mushroom provides a model for the study of mitochondrial DNA.
Explore the source record for details and available documents.
Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male.
Alpers' syndrome is a progressive neurodegenerative disorder with liver disease that usually presents in the first few years of life. Only rarely have patients presented later in life with delayed onset of Alpers' syndrome. Herein we present a case of a 17-year-old male with a progressive 8-month course of severe headaches, multiple stroke-like episodes with visual deficits, and seizures that concluded with acute hemorrhagic pancreatitis. Neuropathological findings were characteristic for Alpers' syndrome: neurodegeneration and astrogliosis of the occipital cortices including the striate cortices, similar but less advanced changes in the parietal cortices, right Ammons horn sclerosis, degeneration of the posterior columns, and mild cerebellar Purkinje cell loss. Examination of the liver revealed extensive centrilobular hepatocyte necrosis. Skeletal muscle did not contain ragged red fibers, nor were there mitochondrial DNA point mutations characteristic for mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).