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Biomedical subjects

F Sabater

Publications and source records attributed to F Sabater.

28 records · Page 2Linked to original sources
PubMed1985

Oxygen consumption during the indole-3-acetic acid oxidation catalyzed by peroxidase. Effect of the enzyme/substrate ratio.

Oxygen consumption during the oxidation of indole-3-acetic acid (IAA) by peroxidase has been studied, in conditions of no limitation by oxygen. For different enzyme/substrate ratios the quotient O2 consumed/IAA oxidized shows rather small differences and it is always less than unity. During the reaction, however, the quotient undergoes important variations because oxygen uptake ceases long before the decarboxylation of IAA. The results are discussed in the light of previous proposed mechanisms.

Free Radicals↗
PubMed1983

Effects of enzyme/substrate ratio and of cofactors on the oxidation products of indole-3-acetic acid catalyzed by peroxidase.

During the oxidation of indole-3-acetic acid catalyzed by peroxidase, the relative amounts of the products closely depends on the enzyme/substrate ratio. In the absence of cofactors, high enzyme/substrate ratio induces a rise in the level of indole-3-aldehyde and indole-3-methanol, and a drop in that of oxindoles. 2,4-dichlorophenol, although a very efficient cofactor, promotes inhibition of the oxidation after a few minutes, presumably through the formation of a phenol-derivative inhibitor. 2-4-dichlorophenol also inhibits the production of oxindoles at all stages. Both inhibitory effects are abolished by a low concentration of enzyme. Mn2+, itself a weak inhibitor, synergizes the catalytic effect of 2,4-dichlorophenol, perhaps by preventing the formation of the inhibitor. The results are discussed against more widely accepted mechanisms of indole-3-acetic acid oxidation.

Chlorophenols↗
PubMedDate not supplied

Leaf litter dynamics and nitrous oxide emission in a Mediterranean riparian forest: implications for soil nitrogen dynamics.

Mediterranean riparian zones can experience severe drought periods that lead to low soil moisture content, which dramatically affects their performance as nitrate removal systems. In the Mediterranean riparian zone of this study, we determined that N2O emission was practically nil. To understand the role of forest floor processes in nitrogen retention of a Mediterranean riparian area, we studied leaf litter dynamics of two tree species, London planetree [Platanus x acerifolia (Aiton) Willd.] and alder [Alnus glutinosa (L.) Gaertn.], for two years, along with soil nitrogen mineralization rates. Annual leaf litter fall equaled 562.6 +/- 10.1 (standard error) g dry wt. m(-2), 68% of which was planetree and 32% of which was alder. The temporal distribution of litterfall showed a two-peak annual cycle, one occurring in midsummer, the other in autumn. Planetree provided the major input of organic nitrogen to the forest floor, and the amount of planetree leaves remaining on the forest floor was equivalent to approximately four years of stock. Leaf litter decomposition was three times higher for alder (decay coefficient [k] = 1.13 yr(-1)) than for planetree (k = 0.365 yr(-1)). Mineralization rates showed a seasonal pattern, with the maximum rate in summer (1.92 mg N kg(-1) d(-1)). Although the forest floor was an important sink for nitrogen due to planetree leaf accumulation, 7.5% of this leaf litter was scoured to the streambed by wind. This loss was irrelevant for alder leaves. Due to the litter quality, the forest floor of this Mediterranean riparian forest acts as a nitrogen sink.

Betulaceae↗
PubMedDate not supplied

[A comparative study of the efficacy of josamycin versus oral penicillin in the treatment of acute tonsillitis].

We have compared the efficacy josamycin (750 mg/12 h/orally) versus penicillin V (500 mg/8 h) for the treatment of acute tonsillitis in a prospective randomized study. Of the 82 eligible patients, 18 were diagnosed of infectious mononucleosis and excluded and the remaining 64 could be evaluated. The duration of the fever and the clinical evolution was similar away the 31 randomized to receive josamycin and the 27 treated with penicillin. In conclusion, josamycin seems to be a useful alternative to penicillin for the treatment of acute tonsillitis.

Acute Disease↗
PubMedDate not supplied

[Ototoxicity of desferrioxamine in hemodialyzed patients].

A prospective study performed on 37 patients with end-stage renal disease who required treatment with deferoxamine is presented. Three patients presented a sudden sensorineural hearing loss, with tinnitus in one case, which was demonstrated to be of cochlear origin. All patients recovered auditory function completely after treatment was discontinued.

Adult↗
PubMedDate not supplied

[Amoxycillin-clavulanic acid and cefuroxime axetil in the treatment of acute sinusitis. A clinical, radiological and bacteriological evaluation].

Cefuroxime axetil (CAE), an orally absorbed product of cefuroxime, and amoxycillin/clavulanate (AAC), were evaluated for their efficacy and safety in the treatment of acute sinusitis. A total of 47 patients were enrolled in a randomized study to compare cefuroxime axetil 500 mg. b.d. for 8 days (25 patients) with amoxycillin/clavulanate 500 mg. t.d.s for 8 days (22 patients). All patients were evaluable for clinical, radiological and bacteriological response. Of 25 clinically assessable patients treated with CAE, 24 were cured, 1 improved and 1 relapsed (96% success rate). Of 22 assessable patients given AAC, 14 were cured and 8 improved (100% success rate). Two out of 25 (8%) patients treated with CAE experienced drug-related adverse events, including 4% with diarrhoea. In the AAC group, 3 out of 22 (13%) patients had a drug-related adverse event, including 13% with diarrhoea. In conclusion, CAE appears to be as safe and effective as AAC in the treatment of acute sinusitis.

Acute Disease↗
PubMedDate not supplied

[Prospective double-blind randomized study of the efficacy and tolerance of topical ciprofloxacin vs topical gentamicin in the treatment of simple chronic otitis media and diffuse external otitis].

A prospective, randomized double-blind study was made of topical ciprofloxacillin (0.5%) compared with topical gentamicin (0.3%) in the treatment of simple chronic otitis media (COM) and diffuse external otitis (DEO). The study included 47 patients with COM and 54 patients with DEO. Success rates in the COM subgroup were 95% for ciprofloxacillin and 96% for gentamicin (p = 0.082), and in the DEO subgroup, 87% for ciprofloxacillin and 79% for gentamicin (p = 0.19). Both drugs were well tolerated and there was no significant change in audiometric measurements with either medication in either group. Therefore, ciprofloxacillin is at least as effective as gentamicin in such ear infections and has no potential ototoxic effect.

Administration, Topical↗