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Biomedical subjects

F Scheler

Publications and source records attributed to F Scheler.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Oestrogen as a risk factor for the vascular system (author's transl)].

Plasma oestradiol and testosterone concentrations were measured in 44 men with angiographically proven coronary heart disease, 66 men without evidence of coronary heart disease serving as control. Another group consisted of 28 men with renal failure. Those with coronary heart disease had a significantly higher oestradiol concentration than the control group. This increased value also was present in patients with renal failure. There was a relationship between the level of oestradiol on one hand and glucose tolerance, ratio of beta to alpha-lipoproteins and blood pressure, on the other, in both the patients with coronary heart disease and the healthy controls. These results indicate the oestradiol may in males be an indicator of a risk constellation of vascular damage. Perhaps, it may be the cause of an abnormal carbohydrate and fat metabolism, which then leads to hypertension and degenerative vascular lesions.

Adult↗
PubMed1980

[Reno-cardiac interactions in kidney failure (author's transl)].

The high incidence of cardiac complications in endstage renal failure is not only related to the chronic pressure load of the left ventricle, although the proportion of patients with elevated blood pressure increases from 53 to 81% as reno-parenchymal disease progresses. Other factors as anemia, hyperparathyroidism, autonomic neuropathy and retention of electrolytes, metabolic products of toxins may cause damage to the heart. It is a matter of discussion whether uremia itself causes cardiomyopathy. Findings of a reduced Ca++-uptake during beta-adrenergic stimulation and a reduced reaction of (Na+, K+)-ATPase to digitalis suggest a basic change of myocardial membrane metabolism. Retention of an "endogenous digitalis" could help to explain some contradictory results.

Adolescent↗
PubMed1980

Biochemical studies on patients undergoing continuous ambulatory peritoneal dialysis.

Biochemical studies are being performed in chronically renal insufficient patients undergoing treatment by CAPD. Serum protein and albumin levels have remained stable during treatment as have the ratios of essential/non-essential amino acids and valine/glycine in plasma. Dietary intake therefore appears to adequately compensate dialysate losses. Serum calcium and phosphate as well as immunoreactive parathyroid hormone concentration and alkaline phosphatase levels did not change during the treatment. The glucose load due to the high concentrations of glucose in the dialysate may have adverse effects on the glucose tolerance and insulin secretion of CAPD patients. However, in fasting patients it could be shown that only the 4.25% glucose dialysate causes any increase in plasma glucose levels with a concommitant rise of insulin secretion, an exchange with a 1.5% glucose dialysate having relatively little effect on these parameters. Quantification of the individual serum lipoproteins is also being performed during CAPD. No changes were observed in alpha-cholesterol levels, but 50% of the patients have shown significant increases in total serum cholesterol, beta-cholesterol and serum triglycerides in the course of treatment. In these cases dietary consequences must be considered in order to minimise the potential artherosclerotic risk.

Adolescent↗
PubMed1980

[First observations with continuous ambulatory peritoneal dialysis (author's transl)].

Continuous ambulatory peritoneal diaglysis (CAPD) represents a new method for treatment of chronic renal failure whereby patients carry two litres of dialysate with them permanently and are freely mobile. Dialysis is only interrupted by exchange of dialysate in approximately 6-hourly intervals. Due to the long presence of the dialysate in the peritoneal cavity clearance values are superior to intermittent peritoneal dialysis for small-molecular substances and reach elimination values of haemofiltration for medium-molecular substances. The main technical requirements consist of a permanent peritoneal dialysis catheter linked to a plastic dialysate bag by way of a connecting tube. In order to avoid frequent change of bag and thus increased risk of peritonitis bags are folded and carried on the body of the patient during the interval. Thereafter the bag is unfolded, filled with used dialysate and exchanged for a new bag. Six patients were thus treated for over 34 patient-months so far. Changes of chemical pathology were readily acceptable. Even though CAPD has several advantages over conventional dialysis as they are mainly founded on the high degree of rehabilitation of patients, risk of peritonitis is still a considerable factor of uncertainty.

Abdomen↗
PubMed1980

Occurrence of highly oxygen-substituted androgens in hemofiltrates of uremic patients.

The steroid fraction of hemofiltrate contains a large number of unknown steroids, which were separated by a combination of different chromatographic procedures and finally characterized by gas chromatography mass spectrometry. Besides different isomeric 3,16,17-trihydroxyandrostanes in a rather polar fraction a 3,16,17-trihydroxy-11-ketoandrostane was detected, obviously the first naturally occurring representative of 3,11,16,17-oxygen-tetrasubstituted androstanes.

Androstanes↗
PubMed1980

Management of anuric intensive-care patients with arteriovenous hemofiltration.

It may be concluded from our results to date, that arteriovenous hemofiltration is an accurate and reliable method for the management of fluid balance in patients resistant to diuretics. Early use of this method may improve the prognosis of intensive-care patients by decongestion or dehydration of lungs, reduction of cardiac pre-and after-load and unrestricted infusion therapy for prevention of catabolism. In addition, the method has been shown to be useful for compensation of uremia and particularly for hypernatremia. The fact that this method requires no investment costs might be of particular interest to many intensive-care units which cannot afford expensive hemodialysis or hemofiltration machines.

Adolescent↗
PubMed1980

Biochemical investigations of CAPD: plasma levels of trace elements and amino acids and impaired glucose tolerance during the course of treatment.

Investigations have been initiated into the effect of CAPD on the plasma concentrations of trace elements and amino acids, and in particular the response of patients to an oral glucose tolerance test (OGTT) during the course of treatment. Six months CAPD had no effect on the plasma concentrations of aluminium, fluoride, zinc and copper. Levels of aluminium and fluoride were above the normal range. Loss of amino acids in the dialysate correlated with their plasma concentrations. No changes were observed in the E/NE, Val/Gly or Tyr/Phe ratios during nine months treatment. Five CAPD patients demonstrated an impaired glucose tolerance in response to an OGTT after one month of treatment and a further deterioration occurred in the glucose tolerance of three patients after another six months CAPD. In a preliminary investigation with fructose substituted for glucose in the dialysate of one patient, an improvement in the OGTT and rate of insulin secretion was observed after 3 days dialysis against fructose.

Adolescent↗
PubMed1979

[Acute renal failure in alcoholic myopathy (author's transl)].

Two chronic alcoholics developed acute renal failure from alcoholic myopathy (acute alcohol-induced rhabdomyolysis). Severe muscle pain developed and was associated with transitory oligo-anuric renal failure, requiring dialysis in one patient. In addition to the typical history and clinical symptoms, excessive elevation of muscle enzymes, especially creatine-kinase, and the appearance of myoglobin in serum are characteristic. Brown discoloration of the urine and a falsely positive test for "blood" due to the presence of myoglobin in urine in the absence of red blood cells are also typical. Definite changes can be demonstrated histologically and electromyographically during the acute stage. It is likely that this condition is more frequent than the sparsity of published reports indicates.

Acute Kidney Injury↗