Biomedical subjects
Publications and source records attributed to F Sitzmann.
A case of dentinogenic ghost cell tumor, that has originated peripherally in the jaw, is presented and the literature reviewed with particular reference to the origin of the tumor. The total number of central and peripheral cases reported in the English literature is 10 and although mucosal infiltration is common, peripheral origin of the neoplasm could be verified in only 3 cases.
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In an experimental study on animals the correlation between the pressure created by periodontal ligament injection and the distribution pattern of the anesthetic solution was examined. It was possible to demonstrate the penetration following intraligamental injection by scintiscanning of the mandibular bone. A correlation between pressure and distribution could not be established.
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The exact regional correlation of findings of facial bone scans, planar or SPECT, to dental orthopan X-ray films (OPT) is difficult because of the very different projection techniques. To improve correlative imaging in this regard a projection algorithm was developed that uses SPECT data of the skull for reconstructing an orthopan tomoscintigraphic projection. Fourteen conventional SPECT slices of the upper and lower jaws were obtained during bone scanning. All mandibular slices were superimposed resulting in a horseshoe shaped structure, while was marked by an ROI which was divided into segments. All 14 SPECT slices were then masked by this segmental ROI, thereby marking the teeth-carrying bone in all slices. The information from this horseshoe like ROI is then transformed into lines. Line by line arrangement results in an orthopan projection, the orthopan tomoscintigram. This new display allows 1:1 true scale superimposition with the X-ray OPT and markedly facilitates correlative imaging.
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A new method for the repair of the cleft alveolus employing the alvolar flap, was carried out in 33 patients with a unilateral total cleft. Alternating primary osteoplastic repairs were performed in in aqual number of patients. The postoperative interval varies between 8 and 9 years. The patients were followed up with attention beng paid to the further growth of the upper jaw.
The anomalies of the ADAM complex arise through amniotic strangulations, adhesions and amputations. In the face cleft formations, displacements and deformities of various structures occur. The limbs exhibit constriction grooves, secondary syndactyle or amptuations. According to observations on 8 patients and information from the literature, the presentation of Adam complexes can vary to an extraordinary degree. The anomalies result from exogenous influences. In genetic counselling phenotypically similar congenital malformations must be separated.
Disturbed wound healing following dentoalveolar procedures may be due to various causes. Necrotizing inflammations with epitheloid cells may easily be mistaken for specific inflammations. Atypical granulomas represent a response to foreign body material (e.g., gelatin sponges). The possibility of sensitization with Gelastypt was tested using immunologic methods.
We report eight patients with the craniofacial defects and limb anomalies of the (amniotic deformity, adhesions, mutilations) ADAM complex. Facial abnormalities comprise clefts and distortion and dislocation of craniofacial structures; limbs show various combinations of amputation, secondary syndactyly, and constriction. From previous reports and our cases it is obvious that the clinical picture of the ADAM complex varies enormously; a less severe type combines cleft lip and palate with amputations or amniotic bands. Clinical and experimental data suggest that these malformations are of symptomatic (exogenous) origin. Nosologic differentiation from other conditions phenotypically similar but of genetic etiology is important for genetic counseling. Observation of the ADAM complex in two members of a family suggests that genetic factors might operate in some cases.
Facultative changes in the teeth, mouth, and jaw in addition to acrogeria, acromicria, and facial erythema are found with Gottron's syndrome. Hypoplasia of the jaw, changes in the position of the teeth, or disproportional relations in the vertical dimensions of the face have been observed. These findings were also recorded in the case described here. The possibility of Gottron's syndrome should be considered if several of the above-mentioned symptoms are present.
A case of Gardners syndrome is described. This illness, inherited by autosomal dominance clinically shows multiple soft tumours, osteotomatosis, occasionally also odeontomata and polyposis intestinalis. The almost invariably occuring malignant degeneration of single intestinal polyps has led to the inclusion of Gardner's syndrome into the group of precancerous conditions.
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