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Biomedical subjects

F Stella

Publications and source records attributed to F Stella.

At least 55 records · Page 3Linked to original sources
PubMed1985

Alpha 1-antitrypsin, transferrin, alkaline phosphatase, phosphohexoseisomerase and gamma-glutamyltransferase in breast cyst fluid.

The levels of alpha 1-antitrypsin, transferrin, alkaline phosphatase, phosphohexoseisomerase and gamma-glutamyltransferase were measured in 32 samples of breast cyst fluid, and a wide range of values was obtained. The levels observed in some samples for these parameters, being similar to those of normal serum, might suggest a mechanism of plasma exudation for the formation of breast cyst fluid. Nevertheless, a comparison with the maximum normal serum reference value revealed very high levels of gamma-glutamyltransferase in all of the samples; about 50% also exhibited high levels of phosphohexoseisomerase. These results indicate that the formation of breast cyst fluid takes place with a specific local production, in addition to the mechanism of selective plasma exudation. Moreover, elevated transferrin levels in some cyst fluids are probably the expression of a high biosynthetic activity and could be diagnostically useful in the course of breast gross cystic disease. The importance of these observations from the point of view of diagnostic and prognostic trends are discussed.

Adolescent↗
PubMed1985

[Differential diagnosis of rejection and cyclosporin nephrotoxicity in organ transplantation using exfoliative urinary cytology].

Although the successful results sealing with Cyclosporin therapy in organ transplantation, side effects such as nephrotoxicity due to drug administration, are still partially solved especially concerning differential diagnosis versus rejection in kidney allograft. On this basis the authors evaluated the application of urinary exfoliative cytology for the monitoring of 110 patients who underwent kidney transplant under Cyclosporin regimen. Among them 33 cases showed direct and/or indirect cytopathic signs of nephrotoxicity induced by Cyclosporin, never observed on over 6000 urinary specimens of renal graphed patients treated with conventional therapy. The authors conclude that urinary exfoliative cytology is a useful, safe and easily repeatable method for the differential diagnosis between rejection and Cyclosporin nephrotoxicity at early stage in kidney transplantation.

Cyclosporins↗
PubMed1984

[Clinical renal transplantation: exfoliative urinary cytology in the evaluation of nephrotoxicity induced by cyclosporin therapy].

Cyclosporine significantly improved the results in organ allograft, nevertheless the drug's potential nephrotoxicity is still causative of problems in differential diagnosis between rejection and graft failure due to Cyclosporine in patients who undergo kidney transplantation. The authors evaluate the effectiveness of a simple method as Urinary Exfoliative Cytology (UEC) in a group of 38 patients who received a kidney allograft and post operative treatment with Cyclosporine. The cytological parameters studied were the following: cytology: cellularity, background, urotelial cells, tubular cells, red cells, polinuclear cells, monocytes, histyocytes, lymphocytes, plasmacells, casts (from 0 to 4+). In all the patients was associated the immunological evaluation--lymphocytes subpopulation markers and function--and Cyclosporine serum levels, together with the hematochemical parameters. In 6 patients with a rise of serum creatinine level the UEC evidentiated intracytoplasmatic eosinophile inclusions in the proximal tubular cells, picture never observed in over 5000 UEC examination of patients treated with post-transplant steroids and azathioprine immunosuppressive regimen. Moreover a complete renal function recovery followed the Cyclosporine dose reduction. The authors conclude that the UEC in kidney allograft is a safe, simple and useful method to assess the early renal damage due to Cyclosporine and to make differential diagnosis between nephrotoxicity and rejection.

Cyclosporins↗
PubMed1984

[Cervicovaginal cytology in women wearing intrauterine devices].

Cervical and vaginal smears in 300 women using (a) intrauterine devices (IUD) and in 300 age matched control subjects (b), have been examined. In women using IUD, endometrial cells have been observed also in the second half of menstrual cycle, conversely these cells are present in women belonging to the control group, just in the first half of the cycle. Pattern of cervico-vaginitis due to Chlamydiae, Actinomyces and Eubacteria have been observed in higher percentage in women IUD wearers 58% of (a) group and 19.3% of (b) group (P less than 0.005). These patterns have often been characterized by the presence of repair cells. Implications in the evaluation of vaginal smears are discussed.

Actinomycosis↗
PubMed1984

[Cytology of breast cysts].

280 cytologic samples obtained by centrifugation of breast cyst fluids were studied. The results of the study on the cellular component and of the background are reported. The analysis was carried out on the cytomorphological aspects of the background, non epithelial cells, normal epithelial cells (foam, galactophoric, apocrine, papillary pictures) and malignant cells. Having described the single cytotypes, their diagnostic values in relation to other techniques are discussed.

Adolescent↗
PubMed1983

[Laboratory diagnosis in clinical renal transplants. II. Exfoliative urinary cytology in non-immunologic complications].

5,800 exfoliative cytology smears have been studied during the period 1979-1982. The study was performed as part of the monitoring in a group of patients who underwent kidney transplant at the II Patologia Speciale Chirurgica, University of Rome (Italy). Cytological findings related to non-immunological complications in the first postoperative period are described and discussed in detail. The urinary exfoliative cytology method in the differential diagnosis among ATN, ischemic tubular necrosis and viral infections, tested by sequentially repeated examinations, could allow a prompt diagnosis before the evidence of clinical and hematochemical signs of renal damage.

Adult↗
PubMed1983

[Laboratory diagnosis in clinical renal transplants. III. Exfoliative urinary cytology in immunologic complications].

The authors summarize their experiences on cytological monitoring in kidney allografts performed at II Patologia Speciale Chirurgica, University of Rome (Italy), during the period 1979-1982. The different aspects of the urinary exfoliative cytology dealing with the post transplant immunological complications, and the differential cytomorphological criteria are described in detail. A good correlation among cytological, immunological and clinical parameters has been observed in 78% of the examined patients. Moreover the cytological findings allowed in 90% of cases an early diagnosis of rejection, increasing the possibility to successfully prevent an irreversible damage of the graft.

Acute Disease↗
PubMed1982

[Laboratory diagnosis in kidney transplants. I. Exfoliative urinary cytology].

Clinical microscopy is a worthwhile method to monitor patients with kidney transplants. The authors describe their experience in 5,800 urinary cytological specimens. The study includes several methods of collecting, processing and staining of the specimens, showing the different cytological pictures: background, hematopoietic-inflammatory cells, renal epithelial cells and casts.

Cytodiagnosis↗
PubMed1982

[Study of bisalbuminemias of the "fast" type].

A case of alloalbuminaemia of the fast type was described in a family living in the district of Pesaro. This was one of the few cases of this particular type and the first observed in this region. Being related to electrophoretic mobility, it is classified as: very fast, type gent. This anomaly has been evidenced by electrophoresis on cellulose acetate, while immunoelectrophoresis with an anti-protein total serum does not reveal the immunological differences referred to in normal albumine.

Adult↗
PubMedDate not supplied

Hydroxyproline and creatinine levels in normal amniotic fluid.

Total hydroxyproline and creatinine concentrations as well as their ratios were determined in 29 amniotic fluid samples from normal pregnancies between the 16th and 20th week of gestation. Total hydroxyproline and creatinine levels, and their ratios, were not statistically different considering either the values at each week or those of the whole 5-week period. Our results, compared with the few others reported in the literature, can provide indications useful for defining the normal range in amniotic fluid, in relation to the weeks of gestation.

Amniotic Fluid↗
PubMedDate not supplied

Cholinesterase evaluation in the prenatal diagnosis of open neural tube defects.

Alpha-fetoprotein (AFP) and cholinesterase levels in amniotic fluid were determined and the efficiency of these laboratory tests in the prenatal diagnosis of neural tube defects was examined. Using the AFP test with cut-off levels correlated to gestational age, we have detected 8 cases of neural tube defects and one case of abdominal wall defect in about 1,200 pregnancies; false-negative values were absent. Acetylcholinesterase (AChE) and butyrylcholinesterase activities were measured and the electrophoretic pattern of AChE was examined in 100 amniotic fluid samples. The diagnosis of neural tube defects was always confirmed. There were no diagnostic problems due to blood-contaminated amniotic fluid samples. The results obtained using different quantitative methods for the determination of cholinesterase activity, as well as the potential use of these tests in routine examinations, are discussed.

Acetylcholinesterase↗
PubMedDate not supplied

[Organizational appropriateness of recoveries: results of the evaluation of recoveries by AEP/PRUO at the Careggi Hospital in Florence in 1995-1998].

The organizational appropriateness of hospital stays is an expression of a hospital's efficiency and aim of the management control. The AEP (American Version)/PRUO (Italian Version) protocol is specific for measuring the organizational appropriateness of hospital stays. The aim of this study is the comparative analysis of the organizational appropriateness of hospital stays in Careggi Hospital of Florence and in all hospital Departments in 1995 and 1998. In 1998 the AEP/PRUO protocol was applied to 2148 samples of hospital stays out of 38,968 eligible hospitalizations, and in 1995 a sample of 1989 hospital stays out of 35,108. In 1998 2,148 admissions and 15,338 days of hospitalization were tested. In 1995, 1989 admission days and 12,264 days of hospitalization were tested, 63 departments were studied. In 1995 the first edition of the protocol was applied, in 1998 the second. A sample of 218 of the 1998 hospital stays was tested with both editions to evaluate the impact of differences. In 1998, with the second edition of the protocol, the inappropriateness rate of admission days and hospitalization days and the rate of in-patients inappropriate hospital stays was respectively 38.0%, 43.8% and 18.5%. Compared with 1995 results, the rates increased +6.2%, 6% and +7.5% respectively. Instead, with the first edition of the protocol, the rates were 29.7%, 37.6% and 10.7% and, compared with 1995, they were reduced -2.1%, -0.6% and -0.3%. The longitudinal multilevel analysis has allowed the evaluation of the performance of each department.

Convalescence↗