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Biomedical subjects

F T McDermott

Publications and source records attributed to F T McDermott.

At least 73 records · Page 4Linked to original sources
PubMed1983

Mucosal dysplasia. A major predictor of cancer following ileorectal anastomosis.

Fifty patients with ulcerative colitis managed by colectomy and ileorectal anastomosis had rectal biopsies performed in the period 1967 to 1972. Follow-up information was available on all patients. Thirty-nine patients were reviewed and rectal biopsies performed in the 1980 to 1982 period. Three patients had developed rectal cancer in the period 1975 to 1980, and two rectal cancers were detected in the 1980 to 1982 follow-up period. All cancers occurred in patients with a diagnosis of moderate or severe dysplasia in biopsy specimens from the 1969 to 1972 period. The probability of developing rectal cancer after a diagnosis of moderate or severe dysplasia in this series reached 42 per cent at nine years from diagnosis.

Adult↗
PubMed1983

Synchronous carcinomas of the large intestine.

Sixty-one (3.0%) of 2029 patients managed operatively for carcinoma of the large intestine had synchronous carcinomas. In 47 (77.0%) of the 61 patients the carcinomas were in the same or adjacent segment(s) of large intestine. Adenomatous polyps were present in 18 (30%) patients compared to 269 (14%) of 1968 patients with a single cancer. A curative resection was performed in 40 of 61 patients, palliative resection in 16 and a non-resection palliative operation in five. Two patients required proctocolectomy and eight subtotal colectomy with ileorectal anastomosis. Cancer specific survival for the entire group and for those treated by curative resection did not differ significantly from that of patients with a single carcinoma. It is concluded that: (1) the presence of a second carcinoma does not significantly alter the survival prospects; (2) both pre-operative large intestinal examination and careful operative palpation of the entire large intestine should be performed, and (3) the significantly higher incidence of adenomatous polyps in patients with synchronous carcinomas is consistent with the polyp/cancer sequence hypothesis.

Adult↗
PubMed1982

Differences in head injuries of pedal cyclist and motorcyclist casualties in Victoria.

There being no legal requirement in Victoria for pedal cyclists to wear crash helmets (and only few do so), we tested the hypothesis that pedal cyclists are subject to significantly greater risk of head injury than motorcyclists, who are required by law to wear them. Injury data of 1975 to 1980 showed that there were three times more fatalities and reported non-fatal casualities among motorcyclists than among pedal cyclists. Head injuries, including fractured vault of skull, fractured base of skull, concussion and intracranial injury, were significantly more frequent among pedal cyclist casualties (P less than 0.001). The number of pedal cyclist casualties with solely head injury was twice that of motorcycle riders, and those pedal cyclist casualties had a significantly greater incidence of fractured vault of the skull. It is likely that risk of head injury for pedal cyclists would be significantly reduced if they wore protective helmets.

Adolescent↗
PubMed1982

Compulsory blood alcohol testing of road crash casualties in Victoria: the second three years (1978-1980).

Since 1974, blood alcohol estimations have been compulsory for all road crash casualties aged 15 years or older presenting at public hospitals in Victoria. This paper details the results of the second sequence of three complete years of testing (1978-1980). Blood samples were obtained from 50712 casualties. There were 41307 of "driver" and 9405 of "non-driver" labelled samples. Of driver and non-driver samples, 20.5% and 17.9% respectively had alcohol levels in excess of the legal driver limit of 11 mmol/L (0.05 g/100 mL). The blood alcohol level exceeded 33 mmol/L (0.15 g/100 mL) in 9.8% of driver and 6.4% of non-driver labelled samples. The legal limit was exceeded by 27.4% of male and 9.2% of female drivers. The percentage of city and country driver casualties who had blood alcohol levels in excess of the legal limit was 18.7% and 25.0%. These results closely resemble those obtained between 1974 and 1977. The differences, while statistically significant, have resulted in less than a 1% decrease in the percentages of drivers and non-drivers with blood alcohol levels in excess of 11 mmol/L (0.05 g/100 mL). The largest annual decrease occurred between 1978 and 1979 and followed increased penalties for drink-driving offences.

Accidents, Traffic↗
PubMed1982

Resection of lung metastases in large bowel cancer.

A series of 14 patients had partial or, in one case, total excision of the lung for metastatic tumour originating in the large bowel. Two patients have survived long periods (9 years and 12 years) and are now apparently free of the disease. A third patient shows no recurrence after bilateral lobectomy 2 years ago. Six of the remaining 11 patients developed isolated pulmonary metastases 5 years and 4 months to 11 years and 4 months after the original bowel resection. All 6 survived for 9 months to 11 years after pulmonary resection before succumbing to the disease. In all 11 patients who died, death was caused by systemic metastases in the brain, spinal cord or bone.

Adenocarcinoma↗
PubMed1982

Cholecystectomy without routine operative cholangiography.

A series of 1575 consecutive patients with cholelithiasis managed by cholecystectomy without operative cholangiography is presented. All operations were performed by one of our authors. Exploration of the bile ducts was performed in 185 (12%) patients. During the postoperative period there was evidence of retained calculi in three (1.6%) of the 185 patients. The incidence of remote calculi (those presenting at a time distant from cholecystectomy) was determined for patients undergoing cholecystectomy between 1963 and 1967. Follow up information was available on 258 (80%) of 321 patients. Clinical evidence of remote calculi was found in seven (2.7%) patients. The incidence of both retained and remote calculi was similar to that found in series where operative cholangiography was routine.

Adolescent↗
PubMed1982

Aspiration of breast cysts.

One hundred and sixty nine women with 220 breast cysts were treated by needle aspiration between 1950 and 1980. Mean follow up was seven years. One hundred and twenty two (72%) patients were aged from 40 to 49 years. The majority (61%) of cysts occurred in the left breast. In 147 patients 174 (79%) of 220 cysts were aspirated once and did not recur at that site. One hundred and eleven (66%) patients presented with a single cyst and had no recurrence in either breast after aspiration. Two patients developed carcinoma of the opposite breast at 8 and 12 years after cyst aspiration. Needle aspiration of the breast is regarded as a safe, simple and economic diagnostic and therapeutic modality in women presenting with single breast lumps.

Adenocarcinoma, Scirrhous↗
PubMed1981

Use of an alcometer in a casualty department.

The use of a fuel cell alcometer for breath testing of blood alcohol concentrations of road crash casualties in a casualty department has been evaluated. A high correlation (r=0.89) was shown between the alcometer breath test results and those obtained by blood analysis at the Victoria Police Forensic Laboratory on 100 road crash casualties. The fuel cell alcometer breath test results were above the legal limit (0.05 g/100 mL) in all casualties in whom the blood analysis result exceeded this level. The facility of obtaining an immediate blood alcohol concentration through the use of a fuel cell alcometer permits the early identification and referral of patients with high blood alcohol concentrations to Alcohol and Drug-dependent Services. After further experience, the fuel cell alcometer may also gain a place as a screening device in Australian States which have enacted legislation for compulsory blood alcohol tests on adult road crash casualties. If so, it could obviate the need to take blood from casualties with a negative alcohol concentration.

Accidents, Traffic↗
PubMed1981

Prognosis in relation to symptom duration in colon cancer.

Between 1950 and 1978 754 patients underwent operation by one of the authors for carcinoma of the colon. Follow-up data were available on 99 per cent. Tumour stage distribution did not differ significantly with increasing duration of symptoms. The proportion of curative to palliative operative procedures was unrelated to symptom duration. Cancer specific survival for the entire patient series was worse when symptoms had been present for less than 3 months compared with 3-6 months, 6-12 months or 12 months or more (P less than 0.001, P less than 0.02 and P less than 0.04, respectively). Cancer specific survival after curative resection was also worse in patients with a symptom duration of less than 3 months compared with 3-6 months or 12 months or more (P less than 0.02 and P less than 0.03, respectively). These results show that colon cancer patients in whom the diagnosis is made and operation performed after a short symptomatic period do not have less advanced tumours nor better survival prospects.

Adult↗
PubMed1981

Comparative results of surgical management of single carcinomas of the colon and rectum: a series of 1939 patients managed by one surgeon.

A comparative analysis has been made of the results of surgical management of single carcinomas of the colon and rectum in a series of 1939 patients treated by one surgeon. The data were prospectively collected, with 99 per cent follow-up. Cancer specific survival did not differ significantly between patients with colonic or rectal cancer. Survival prospects were better for women (P = 0.02) and for patients less than 40 years of age (P = 0.03). Survival was significantly related to tumour staging (P less than 0.002). Cancer specific survival was better after curative resection for colonic than rectal carcinoma (P = 0.003). Five-year survival for patients with colonic tumours was 76 per cent and for rectal tumours 69 per cent. The 10-year survival figures were 73 per cent and 51 per cent respectively. This difference was accounted for by a higher proportion of Dukes' stage C tumours in the rectum (P less than 0.001) and better survival prospects for colonic compared to rectal stage C1 tumours (P = 0.02). Sphincter-saving resections were performed in 64 per cent of rectal cancer patients managed by curative resection. Survival tended to be better than after sphincter-sacrificing operations. After palliative resection, median survival for colonic and rectal cancer was 14 and 13 months respectively. After palliative bypass operations the corresponding figures were 4 and 8 months.

Adenocarcinoma↗