PubMed Health⌕ Search

Biomedical subjects

F Tedeschi

Publications and source records attributed to F Tedeschi.

At least 37 records · Page 2Linked to original sources
PubMed1981

Darier's keratosis follicularis: an ultrastructural study during and after topical treatment with retinoic acid alone or in combination with 5-fluorouracil.

An ointment containing 0.05% retinoic acid (RA) was applied to the anterior surface of the chest in a patient suffering from Darier's keratosis follicularis. A mixture of two ointments containing equal amounts of 5% 5-fluorouracil (5-FU) and 0.05% RA was used on the dorsum of the same patient. Biopsies were taken 30 days and 70 days after treatment started. Retinoic acid gave rise to an initial disorganisation of desmosomes; the "corps ronds" and "grains" disappeared, the lacunae gradually decreased in size, and the epidermis was practically normal when the clinical manifestations of the skin had disappeared. The damage induced with the RA + 5-FU mixture was more serious, but when the skin lesions relapsed they did so later and in a less severe way than the recurrences observed after treatment with RA alone.

Darier Disease↗
PubMed1981

Fine structure of granular cell tumor of Abrikosov.

The case report illustrates the microscopical and ultrastructural findings obtained in a case of Abrikossoff's tumor. On the basis of the light and ultrastructural data a neural histogenesis is suggested.

Adult↗
PubMed1981

Computer-assisted karyotyping system of banded chromosomes.

The banding automatic system (BAS) we describe in this paper is a computer-assisted karyotyping system suitable for the analysis of both normal and abnormal karyotypes in banded chromosome specimens. In the BAS system recognition of the various features and constituents of the chromosomes is performed by an operator, whereas chromosome identification and classification are entrusted to a computer. The connection between operator and computer is the CYGEN1 program, which is tailored to distinguish chromosome morphology on the basis of the operator input band patterns alone. The karyotyping operation is therefore significantly speeded up: the operator simply has to read through a certain number of banded metaphases, encoding band-pattern data to the computer. The machine signals when the operation has gone through the whole karyotype or, for instance, when chromosomes are missing or present in extra number above the significance level from the analyzed metaphases. Chromosome identification and classification are then carried out by the computer, which performs as a real-time recognizing key. Moreover, the data being accumulated in the computer will provide a file of cytogenetic records accessible to the operator, as well as to the computer, for further diagnostic operations. The efficacy of the BAS system is demonstrated for the diagnosis of various structural aberrations, including a complex translocation. The processing of 20 metaphases by the method described takes 40-45 min, and a cytogenetic technician can make effective use of the system after 25-30 h of intensive training.

Chromosome Aberrations↗
PubMed1981

Symptomatic subependymoma of the fourth ventricle. Case report.

Symptomatic subependymomas of the fourth ventricle are rare and usually not included in the preoperative differential diagnosis of tumors in this region. The case of a 63-year-old man with fourth ventricle subependymoma is described. For several years he had suffered with nausea and vomiting, and now presented signs of direct involvement of the posterior fossa. He was investigated preoperatively with computerized tomography, but the ultimate diagnosis was not suspected at that time. The tumor was diagnosed as an subependymoma at operation and was totally excised. This tumor type can easily be recognized on intraoperative frozen section, and its diagnosis should always lead to an attempt at complete surgical removal.

Cerebral Ventricle Neoplasms↗
PubMed1981

[Renal lesions in a case of tuberous sclerosis: association of angiomyolipoma, bilateral polycystic kidney and renal clear-cell carcinoma].

Association cases of tuberous sclerosis (ST) and renal displasia-tumors are infrequently seen in literature. These tumors are bilateral renal cystic displasia (RP) rare hamartomas, p.e. angiomyolipomas, and malignant neoplasms, p.e. renal clear cell carcinomas. There therefor as to the frequency of those pathological associations with ST, AML are frequently seen (50-80%). Reports of polycystic renal disease with ST are rare, whereas occasional associations of renal cell carcinomas with ST are founded out. By extensive literature examination of it's evident that the synchronous association of these pathological lesions is exceptional. This report describes one case of AML, RP and renal clear cell carcinoma in a female, 22 years old, with ST; the pathological, clinical and pathogenetic features are discussed.

Adenocarcinoma↗
PubMed1978

[Transplantable experimental tumor. Morphological and ultrastructural study (author's transl].

An experimental tumor which has been induced in newborn chicken, was transplanted into inbred BALB/c mice and then studied by the means of light and electron microscopy. Sendai virus fusion between MSV-H transformed rat cells and chickembryo cells provided the tumor. Histological pattern of this neoplasia seems to be superposable, both in chicken and in mouse, to that of anaplastic fibrosarcomas and shows some differences from either Rous sarcoma or BALB/c mouse H-6668 spontaneous rabdomyosarcoma patterns. tumor malignancy was evaluated onthe basis of rapid growth

Animals↗
PubMed1978

[Uremic-hemolytic syndrome: clinical and pathological observations of a case (author's transl)].

A case of uremic hemolytic syndrome observed in a 20 months old child has been investigated from the clinical and pathological point of view. All specific clinical manifestations of the syndrome were present as well as the pathognomic pathological finding of a renal trombotic microangiopathy. In addition a generalized lymphoadenopathy likely related to a previous vaccination, was also found. The possible role of such an immune reaction in the pathogenesis of the syndrome in the present case is discussed.

Biopsy↗
PubMedDate not supplied

[Epidemic due to group B Coxsackie viruses in a newborn infants' department (author's transl)].

Virological and clinical researches have been done on hospitalized newborn infants' with various infectious diseases (respiratory infections, aseptic meningitis, serious generalized disease). Initially from some newborn children Coxsackie B5 virus has been isolated and later from other patients Coxsackie B3 virus. The pathological findings, in those newborn who died as a result of serious generalized disease were dominated by hemorragic lesions in different organs.

Coxsackievirus Infections↗
PubMedDate not supplied

Minichromosome maintenance protein 7: a reliable tool for glioblastoma proliferation index.

At present there is increasing evidence concerning the value of minichromosome maintenance (MCM) protein expression as a novel indicator of proliferation. In the present study, 15 glioblastoma samples, classified according to WHO, were analysed to evaluate the expression of the principal proliferation markers. The samples examined were subdivided into 2 cytological subsets, small cell (SC) or multiforme cell (MC) glioblastoma, according to the predominant cell type defined in individual specimens. MCM7 detected more cells in the cycle than Ki67 and PCNA and all cases of SC glioblastoma, the most aggressive subset, displayed a significant increase of MCM7-stained nuclei versus those stained with Ki67. These results suggest that the cell cycle-associated proteins MCM are not only useful markers of proliferation, but also valid aids for diagnosis in cerebral glioblastoma.

Adult↗
PubMedDate not supplied

Primary non-Hodgkin's lymphoma of the kidney.

A 53-year-old woman was admitted to the hospital because of end-stage renal failure of unknown etiology. She had to begin hemodialysis a few days later. An open biopsy showed non-Hodgkin's lymphoma of the kidney. The patient died after the first cycle of chemotherapy and necroscopy confirmed that the lymphomatous involvement of the kidney was primary. From the current literature we are not aware of other cases of primary non-Hodgkin's lymphoma of the kidney.

Diagnosis, Differential↗